메뉴 건너뛰기




Volumn 26, Issue 9 I, 2006, Pages 1255-1261

Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults

Author keywords

Coadministration; Intracellular concentration; Pharmacokinetics; Plasma concentration; Quercetin; Saquinavir

Indexed keywords

ABC TRANSPORTER; ANTIPARASITIC AGENT; BIOFLAVONOID; CONTRACEPTIVE AGENT; CYCLOSPORIN; CYTOCHROME P450 1A1; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DIGOXIN; GARLIC EXTRACT; GLYCOPROTEIN P; HERBACEOUS AGENT; HORMONE; HYPERICUM PERFORATUM EXTRACT; INTESTINE ENZYME; LIVER ENZYME; MESSENGER RNA; MOXIDECTIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; NON PRESCRIPTION DRUG; PACLITAXEL; QUERCETIN; RHODAMINE 123; SAQUINAVIR; VERAPAMIL;

EID: 33748096809     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.26.9.1255     Document Type: Article
Times cited : (19)

References (30)
  • 1
    • 0034639643 scopus 로고    scopus 로고
    • Indinavir concentrations and St John's wort
    • Piscitelli SC, Burstein AH, Chaitt D, et al. Indinavir concentrations and St John's wort. Lancet 2000;355:547-8.
    • (2000) Lancet , vol.355 , pp. 547-548
    • Piscitelli, S.C.1    Burstein, A.H.2    Chaitt, D.3
  • 3
    • 0025790338 scopus 로고
    • Antiviral properties of Ro 31-8959, an inhibitor of human immunodeficiency virus (HIV) proteinase
    • Craig JC, Duncan IB, Hockley D, Grief C, Roberts NA, Mills JS. Antiviral properties of Ro 31-8959, an inhibitor of human immunodeficiency virus (HIV) proteinase. Antivir Res 1991;16:295-305.
    • (1991) Antivir Res , vol.16 , pp. 295-305
    • Craig, J.C.1    Duncan, I.B.2    Hockley, D.3    Grief, C.4    Roberts, N.A.5    Mills, J.S.6
  • 4
    • 0034128937 scopus 로고    scopus 로고
    • Dual protease inhibitor therapy in HIV-infected patients: Pharmacologic rationale and clinical benefits
    • Flexner C. Dual protease inhibitor therapy in HIV-infected patients: pharmacologic rationale and clinical benefits. Annu Rev Pharmacol Toxicol 2000;40:649-74.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 649-674
    • Flexner, C.1
  • 5
    • 0031024382 scopus 로고    scopus 로고
    • Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: Potential contribution to high first-pass metabolism
    • Fitzsimmons ME, Collins JM. Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism. Drug Metab Dispos 1997;25:256-66.
    • (1997) Drug Metab Dispos , vol.25 , pp. 256-266
    • Fitzsimmons, M.E.1    Collins, J.M.2
  • 6
    • 0027275829 scopus 로고
    • P-glycoprotein (MDR1 gene product) in cells of the immune system: Its possible physiologic role and alteration in aging an human immunodeficiency virus-1 (HIV-1) infection
    • Gupta S, Gollapudi S. P-glycoprotein (MDR1 gene product) in cells of the immune system: its possible physiologic role and alteration in aging an human immunodeficiency virus-1 (HIV-1) infection. J Clin Immunol 1993;13:289-301.
    • (1993) J Clin Immunol , vol.13 , pp. 289-301
    • Gupta, S.1    Gollapudi, S.2
  • 7
    • 0025145490 scopus 로고
    • Human immunodeficiency virus 1-induced expression of P-glycoprotein
    • Gollapudi S, Gupta S. Human immunodeficiency virus 1-induced expression of P-glycoprotein. Biochem Biophys Res Commun 1990;171:1002-7.
    • (1990) Biochem Biophys Res Commun , vol.171 , pp. 1002-1007
    • Gollapudi, S.1    Gupta, S.2
  • 8
    • 0028149110 scopus 로고
    • Zidovudine increases the expression of cellular resistance affecting its antiviral activity
    • Diazani F, Antonelli G, Turriziani O, et al. Zidovudine increases the expression of cellular resistance affecting its antiviral activity. AIDS Res Hum Retroviruses 1994;10:1471-8.
    • (1994) AIDS Res Hum Retroviruses , vol.10 , pp. 1471-1478
    • Diazani, F.1    Antonelli, G.2    Turriziani, O.3
  • 10
    • 0034937284 scopus 로고    scopus 로고
    • Quercetin glucuronides but not glucosides are present in human plasma after consumption of quercetin-3-glucoside or quercetin-4-glusoside
    • Sesink ALA, O'Leary KA, Hollman PCH. Quercetin glucuronides but not glucosides are present in human plasma after consumption of quercetin-3- glucoside or quercetin-4-glusoside. J Nutr 2001;131:1938-41.
    • (2001) J Nutr , vol.131 , pp. 1938-1941
    • Sesink, A.L.A.1    O'Leary, K.A.2    Hollman, P.C.H.3
  • 11
    • 0033661837 scopus 로고    scopus 로고
    • Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers
    • Erlund I, Kosonen T, Alfthan G, et al. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur J Clin Pharm 2000;56:545-53.
    • (2000) Eur J Clin Pharm , vol.56 , pp. 545-553
    • Erlund, I.1    Kosonen, T.2    Alfthan, G.3
  • 12
    • 0027981909 scopus 로고
    • Quercetin potentiates the effect of Adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target
    • Scambia G, Ranelletti FO, Panici PB, et al. Quercetin potentiates the effect of Adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target. Cancer Chemother Pharmacol 1994;34:459-64.
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 459-464
    • Scambia, G.1    Ranelletti, F.O.2    Panici, P.B.3
  • 13
    • 0037032676 scopus 로고    scopus 로고
    • Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats
    • Hsiu SL, Hou YC, Wang YH, Tsao CW, Su SF, Chao PD. Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats. Life Sci 2002;72:227-35.
    • (2002) Life Sci , vol.72 , pp. 227-235
    • Hsiu, S.L.1    Hou, Y.C.2    Wang, Y.H.3    Tsao, C.W.4    Su, S.F.5    Chao, P.D.6
  • 14
    • 0033917295 scopus 로고    scopus 로고
    • Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression
    • Obach RS. Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 2000;294:88-95.
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 88-95
    • Obach, R.S.1
  • 15
    • 0037466186 scopus 로고    scopus 로고
    • Determination of protease inhibitors using liquid chromatography-tandem mass spectrometry
    • Frerichs VA, DiFrancesco R, Morse GD. Determination of protease inhibitors using liquid chromatography-tandem mass spectrometry. J Chromatogr 2003;787:393-403.
    • (2003) J Chromatogr , vol.787 , pp. 393-403
    • Frerichs, V.A.1    DiFrancesco, R.2    Morse, G.D.3
  • 16
    • 1442359716 scopus 로고    scopus 로고
    • Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin
    • Choi JS, Jo BW, Kim YC. Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin. Eur J Pharm Biopharm 2004;57:313-18.
    • (2004) Eur J Pharm Biopharm , vol.57 , pp. 313-318
    • Choi, J.S.1    Jo, B.W.2    Kim, Y.C.3
  • 18
    • 0037465616 scopus 로고    scopus 로고
    • Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: Quercetin
    • Dupuy J, Larrieu G, Sutra JF, Lespine A, Alvinerie M. Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin. Vet Parasitol 2003;112:337-47.
    • (2003) Vet Parasitol , vol.112 , pp. 337-347
    • Dupuy, J.1    Larrieu, G.2    Sutra, J.F.3    Lespine, A.4    Alvinerie, M.5
  • 19
    • 0032865554 scopus 로고    scopus 로고
    • Inhibition of CYP3A4-mediated and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components
    • Eaglin VA, Profit L, Back DJ. Inhibition of CYP3A4-mediated and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol 1999;48:543-52.
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 543-552
    • Eaglin, V.A.1    Profit, L.2    Back, D.J.3
  • 21
    • 0037403686 scopus 로고    scopus 로고
    • Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products
    • Raucy JL. Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products. Drug Metab Dispos 2003;31:533-9.
    • (2003) Drug Metab Dispos , vol.31 , pp. 533-539
    • Raucy, J.L.1
  • 22
    • 20444447208 scopus 로고    scopus 로고
    • Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine
    • Wang L, Morris ME. Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine. J Chromatogr B 2005;821:194-201.
    • (2005) J Chromatogr B , vol.821 , pp. 194-201
    • Wang, L.1    Morris, M.E.2
  • 23
    • 0030782511 scopus 로고    scopus 로고
    • Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities
    • Shapiro AB, Ling V. Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities. Eur J Biochem 1997;250:130-7.
    • (1997) Eur J Biochem , vol.250 , pp. 130-137
    • Shapiro, A.B.1    Ling, V.2
  • 24
    • 0033083015 scopus 로고    scopus 로고
    • Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone: Evidence for a third drug-binding site
    • Shapiro AB, Fox K, Lam P, Ling V. Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone: evidence for a third drug-binding site. Eur J Biochem 1999;259:841-50.
    • (1999) Eur J Biochem , vol.259 , pp. 841-850
    • Shapiro, A.B.1    Fox, K.2    Lam, P.3    Ling, V.4
  • 25
    • 0036839699 scopus 로고    scopus 로고
    • Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2)
    • Williams GC, Liu A, Knipp G, Sinko PJ. Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2). Antimicrob Agents Chemother 2002;46:3456-62.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3456-3462
    • Williams, G.C.1    Liu, A.2    Knipp, G.3    Sinko, P.J.4
  • 26
    • 0043157305 scopus 로고    scopus 로고
    • Intracellular indinavir pharmacokinetics in HIV-infected patients: Comparison with plasma pharmacokinetics
    • Hennessy M, Clarke S, Spiers JP, et al. Intracellular indinavir pharmacokinetics in HIV-infected patients: comparison with plasma pharmacokinetics. Antivir Ther 2002;8:191-8.
    • (2002) Antivir Ther , vol.8 , pp. 191-198
    • Hennessy, M.1    Clarke, S.2    Spiers, J.P.3
  • 27
    • 1542288853 scopus 로고    scopus 로고
    • Intracellular accumulation of nelfinavir and its relationship to P-glycoprotein expression and function in HIV-infected patients
    • Hennessy M, Clarke S, Spiers JP, et al. Intracellular accumulation of nelfinavir and its relationship to P-glycoprotein expression and function in HIV-infected patients. Antivir Ther 2004;9:115-22.
    • (2004) Antivir Ther , vol.9 , pp. 115-122
    • Hennessy, M.1    Clarke, S.2    Spiers, J.P.3
  • 28
    • 0013095102 scopus 로고    scopus 로고
    • MDR1 genotype-related pharmacokinetics and pharmacodynamics
    • SaKaeda T, Nakamura T, Okumura K. MDR1 genotype-related pharmacokinetics and pharmacodynamics. Biol Pharm Bull 2002;25:1391-400.
    • (2002) Biol Pharm Bull , vol.25 , pp. 1391-1400
    • SaKaeda, T.1    Nakamura, T.2    Okumura, K.3
  • 29
    • 3042772026 scopus 로고    scopus 로고
    • Identification of functionally variant MDR1 alleles among European Americans and African Americans
    • Kim RB, Leake BF, Choo EF, et al. Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther 2001;70:189-99.
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 189-199
    • Kim, R.B.1    Leake, B.F.2    Choo, E.F.3
  • 30
    • 0036796994 scopus 로고    scopus 로고
    • P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals
    • Maeden ER, Hoggard PG, Newton P, et al. P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals. J Antimicrob Chemother 2002;50:583-8.
    • (2002) J Antimicrob Chemother , vol.50 , pp. 583-588
    • Maeden, E.R.1    Hoggard, P.G.2    Newton, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.