Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells

Pediatric Research

Volumn 60, Issue 1, 2006, Pages 38-43

  Hermann, Emmanuel ^a,e,f   Alonso Vega, Cristina ^b,g   Berthe, Aurelie ^a,f   Truyens, Carine ^a   Flores, Amilcar ^b   Cordova, Marisol ^b   Moretta, Lorenzo ^c   Torrico, Faustino ^b   Braud, Veronique ^d   Carlier, Yves ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b Centro Universitario de Medicina Tropical   (Bolivia)

^c G GASLINI INSTITUTE   (Italy)

^d INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^e INSERM   (France)

^f Institut Pasteur de Lille ^*

^g Assoc Pour la Prom de l'Education et la Formation a l'Etranger (Communaute Francaise de Belgique)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 15;

ARTICLE; CELL ACTIVATION; CELL STIMULATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOID ORGAN; NATURAL KILLER CELL; PHENOTYPE; PRIORITY JOURNAL; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS; UMBILICAL CORD; UMBILICAL CORD BLOOD;

ANIMALS; ANTIGENS, CD56; CHAGAS DISEASE; DOWN-REGULATION; FETAL BLOOD; GRANZYMES; HUMANS; INFANT, NEWBORN; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-15; INTERLEUKIN-2; KILLER CELLS, NATURAL; MEMBRANE GLYCOPROTEINS; PHENOTYPE; RECEPTORS, IMMUNOLOGIC; SERINE ENDOPEPTIDASES; TRYPANOSOMA CRUZI;

EID: 33748085409     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000220335.05588.ea     Document Type: Article

References (30)

1. Adkins B, Leclerc C, Marshall-Clarke S 2004 Neonatal adaptive immunity comes of age. Nat Rev Immunol 4:553-564
2. Hermann E, Truyens C, Alonso-Vega C, Even J, Rodriguez P, Berthe A, Gonzalez-Merino E, Torrico F, Carlier Y 2002 Human fetuses are able to mount an adultlike CD8 T-cell response. Blood 100:2153-2158
3. Marchant A, Appay V, Van der Sande M, Dulphy N, Liesnard C, Kidd M, Kaye S, Ojuola O, Gillespsie GM, Vargas Cuero AL, Cerundolo V, Callan M, McAdam KP, Rowland-Jones SL, Donner C, McMichael AJ, Whittle H 2003 Mature CD8(+) T lymphocyte response to viral infection during fetal life. J Clin Invest 111:1747-1755
4. Cooper MA, Fehniger TA, Fuchs A, Colonna M, Caligiuri MA 2004 NK cell and DC interactions. Trends Immunol 25:47-52
5. Geldhof AB, Van Ginderachter JA, Liu Y, Noel W, Raes G, De Baetselier P 2002 Antagonistic effect of NK cells on alternatively activated monocytes: a contribution of NK cells to CTL generation. Blood 100:4049-4058
6. Moretta L, Moretta A 2004 Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J 23:255-259
7. Shiroishi M, Tsumoto K, Amano K, Shirakihara Y, Colonna M, Braud VM, Allan DS, Makadzange A, Rowland-Jones S, Willcox B, Jones EY, van der Merwe PA, Kumagai I, Maenaka K 2003 Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. Proc Natl Acad Sci U S A 100:8856-8861
8. Braud VM, Allan DS, O'Callaghan CA, Soderstrom K, D'Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL, McMichael AJ 1998 HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 391:795-799
9. Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T 1999 Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285:727-729
10. Gaddy J, Risdon G, Broxmeyer HE 1995 Cord blood natural killer cells are functionally and phenotypically immature but readily respond to interleukin-2 and interleukin-12. J Interferon Cytokine Res 15:527-536
11. Torrico F, Alonso-Vega C, Suarez E, Rodriguez P, Torrico MC, Dramaix M, Truyens C, Carlier Y 2004 Maternal Trypanosoma cruzi infection, pregnancy outcome, morbidity, and mortality of congenitally infected and non-infected newborns in Bolivia. Am J Trop Med Hyg 70:201-209
12. Gaddy J, Broxmeyer HE 1997 Cord blood CD16+56- cells with low lytic activity are possible precursors of mature natural killer cells. Cell Immunol 180:132-142
13. Cooper MA, Fehniger TA, Caligiuri MA 2001 The biology of human natural killer-cell subsets. Trends Immunol 22:633-640
14. Bennett IM, Zatsepina O, Zamai L, Azzoni L, Mikheeva T, Perussia B 1996 Definition of a natural killer NKR-P1A+/CD56-/CD16- functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12. J Exp Med 184:1845-1856
15. Sivori S, Falco M, Marcenaro E, Parolini S, Biassoni R, Bottino C, Moretta L, Moretta A 2002 Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation. Proc Natl Acad Sci U S A 99:4526-4531
16. De Maria A, Fogli M, Costa P, Murdaca G, Puppo F, Mavilio D, Moretta A, Moretta L 2003 The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44). Eur J Immunol 33:2410-2418
17. Costello RT, Sivori S, Marcenaro E, Lafage-Pochitaloff M, Mozziconacci MJ, Reviron D, Gastaut JA, Pende D, Olive D, Moretta A 2002 Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia. Blood 99:3661-3667
18. Groh V, Wu J, Yee C, Spies T 2002 Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 419:734-738
19. Castriconi R, Cantoni C, Della CM, Vitale M, Marcenaro E, Conte R, Biassoni R, Bottino C, Moretta L, Moretta A 2003 Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells. Proc Natl Acad Sci U S A 100:4120-4125
20. Ming M, Ewen ME, Pereira ME 1995 Trypanosome invasion of mammalian cells requires activation of the TGF beta signaling pathway. Cell 82:287-296
21. Moretta A 2002 Natural killer cells and dendritic cells: rendezvous in abused tissues. Nat Rev Immunol 2:957-964
22. Fehniger TA, Cooper MA, Nuovo GJ, Cella M, Facchetti F, Colonna M, Caligiuri MA 2003 CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. Blood 101:3052-3057
23. Ross ME, Caligiuri MA 1997 Cytokine-induced apoptosis of human natural killer cells identifies a novel mechanism to regulate the innate immune response. Blood 89:910-918
24. Wang KS, Frank DA, Ritz J 2000 Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4. Blood 95:3183-3190
25. Pien GC, Biron CA 2000 Compartmental differences in NK cell responsiveness to IL-12 during lymphocytic choriomeningitis virus infection. J Immunol 164:994-1001
26. Robbins SH, Tessmer MS, Mikayama T, Brossay L 2004 Expansion and contraction of the NK cell compartment in response to murine cytomegalovirus infection. J Immunol 173:259-266
27. Lieke T, Graefe SE, Klauenberg U, Fleischer B, Jacobs T 2004 NK cells contribute to the control of Trypanosoma cruzi infection by killing free parasites by perforin-independent mechanisms. Infect Immun 72:6817-6825
28. Artavanis-Tsakonas K, Eleme K, McQueen KL, Cheng NW, Parham P, Davis DM, Riley EM 2003 Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes. J Immunol 171:5396-5405
29. Nylen S, Maasho K, Soderstrom K, Ilg T, Akuffo H 2003 Live Leishmania promastigotes can directly activate primary human natural killer cells to produce interferon-gamma. Clin Exp Immunol 131:457-467
30. Qian JX, Lee SM, Suen Y, Knoppel E, van de Ven C, Cairo MS 1997 Decreased interleukin-15 from activated cord versus adult peripheral blood mononuclear cells and the effect of interleukin-15 in upregulating antitumor immune activity and cytokine production in cord blood. Blood 90:3106-3117