Compartmental differences in NK cell responsiveness to IL-12 during lymphocytic choriomeningitis virus infection

Journal of Immunology

Volumn 164, Issue 2, 2000, Pages 994-1001

  Pien, Gary C ^a   Biron, Christine A ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; RECOMBINANT INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; INTERFERON INDUCTION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS MENINGITIS;

EID: 0034650435     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.2.994     Document Type: Article

References (30)

1. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
2. Monteiro, J. M., C. Harvey, and G. Trinchieri. 1998. Role of interleukin-12 in primary influenza virus infection. J. Virol.72:4825.
3. Biron, C. A., and R. T. Gazzinelli. 1995. Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr. Opin. Immunol. 7:485.
4. Biron, C. A. 1997. Activation and function of natural killer cell responses during viral infections. Curr. Opin. Immunol. 9:24.
5. Biron, C. A., K. B. Nguyen, G. C. Pien, L. P. Cousens, and T. P. Salazar-Mather. 1999. Natural killer (NK) cells in anti-viral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17:189.
6. Gazzinelli, R. T., S. Hieny, T. A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. USA 90:6115.
7. Orange, J. S., and C. A. Biron. 1996. An absolute and restricted requirement for IL-12 in natural killer cell IFN-γ production and antiviral defense. J. Immunol. 156:1138.
8. Cousens, L. P., J. S. Orange, H. C. Su, and C. A. Biron. 1997. Interferon-αβ inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection. Proc. Natl. Acad. Sci. USA 94:634.
9. Moskophidis D., M. Battegay, M. A. Bruendler, E. Laine, I. Gresser, and R. M. Zinkernagel. 1994. Resistance of lymphocytic choriomeningitis virus to αβ interferon and to γ interferon. J. Virol. 68:1951.
10. Wang B., C. Biron, J. She, K. Higgins, M.-J. Sunshine, E. Lacy, N. Lonberg, and C. Terhorst. 1994. A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3∈ gene. Proc. Natl. Acad. Sci. USA 91:9402.
11. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259:1739.
12. Schoenhaut, D. S., A. O. Chua, A. G. Wolitzky, P. M. Quinn, C. M. Dwyer, W. McComas, P. C. Familletti, M. K. Gately, and U. Gubler. 1992. Cloning and expression of murine IL-12. J. Immunol. 148:3433.
13. Talmadge, J. E., R. B. Herberman, M. A. Chirigos, A. E. Maluish, M. A. Schneider, J. S. Adams, H. Philips, G. B. Thurman, L. Varesio, C. Long, et at. 1985. Hyporesponsiveness to augmentation of murine natural killer cell activity in different anatomical compartments by multiple injections of various immunomodulators including recombinant interferons and interleukin 2. J. Immunol. 135:2483.
14. Orange, J. S., B. Wang, C. Terhorst, and C. A. Biron. 1995. Requirement for natural killer cell-produced interferon-γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J. Exp. Med. 182:1045.
15. Orange, J. S., and C. A. Biron. 1996. Characterization of early IL-12, IFN-αβ, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J. Immunol. 156:4746.
16. Nguyen, K. B., and C. A. Biron. 1999. Synergism for cytokine-mediated disease during concurrent endotoxin and viral challenges: roles for NK and T cell IFN-γ production. J. Immunol. 162:5238.
17. Orange, J. S., S. F. Wolf, and C. A. Biron. 1994. Effects of IL-12 on the response and susceptibility to experimental viral infections. J. Immunol. 152:1253.
18. Warren, H. S., B. F. Kinnear, J. H. Phillips, and L. L. Lanier 1995. Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4, IL-10, and IL-12. J. Immunol. 154:5144.
19. Peritt, D., S. Robertson, G. Gri, L. Showe, M. Aste-Amezaga, and G. Trinchieri. 1998. Differentiation of human NK cells into NK1 and NK2 subsets. J. Immunol. 161:5821.
20. Hoshino, T., R. T. Winkler-Pickett, A. T. Mason, J. R. Ortaldo, and H. A. Young. 1999. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-γ J. Immunol. 162:51.
21. Orange, J. S., T. P. Salazar-Mather, S. M. Opal, R. L. Spencer, A. H. Miller, B. S. McEwen, and C. A. Biron. 1995. Mechanisms of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids. J. Exp. Med. 181:901.
22. Bi, Z., P. Quandt, T. Komatsu, M. Barna, and C. S. Reiss. 1995. IL-12 promotes enhanced recovery from vesicular stomatitis virus infection of the central nervous system. J. Immunol. 155:5684.
23. Ireland, D. D., T. Bang, T. Komatsu, and C. S. Reiss. 1999. Delayed administration of interleukin-12 is efficacious in promoting recovery from lethal viral encephalitis. Viral Immunol. 12:35.
24. Carr, J. A., J. Rogerson, M. J. Mulqueen, N. A. Roberts, and R. F. G. Booth. 1997. Interleukin-12 exhibits potent antiviral activity in experimental herpesvirus infections. J. Virol. 71:7799.
25. Kawanishi, Y., N. Hayashi, K. Katayama, K. Ueda, T. Takehara, E. Miyoshi, E. Mita, A. Kasahara, H. Fusamoto, and T. Kamada. 1995. Tumor necrosis factor-α and interferon-γ inhibit synergistically viral replication in hepatitis B virus-replicating cells. J. Med. Virol. 47:272.
26. Cavanaugh, V. J., L. G. Guidotti, and F. V. Chisari. 1997. Interleukin-12 inhibits hepatitis B virus replication in transgenic mice. J. Virol. 71:3236.
27. Schultz, U., and F. V. Chisari. 1999. Recombinant duck interferon γ inhibits duck hepatitis B virus replication in primary hepatocytes. J. Virol. 73:3162.
28. Carreno, V., and J. A. Quiroga. 1997. Biological properties of interleukin-12 and its therapeutic use in persistent hepatitis B virus and hepatitis C virus infection. J. Viral Hepat. 4 (Suppl. 2):83.
29. Orange, J. S., T. P. Salazar-Mather, S. M. Opal, and C. A. Biron. 1997. Mechanisms for virus-induced liver disease: tumor necrosis factor-mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection. J. Virol. 71:9248.
30. Salazar-Mather, T. P., J. S. Orange, and C. A. Biron. 1998. Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1α (MIP-1α)-dependent pathways. J. Exp. Med. 187:1.