Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT 1B rather than 5-HT 1D receptors

British Journal of Pharmacology

Volumn 149, Issue 1, 2006, Pages 82-91

  Muoz Islas E ^a   Gupta, S ^b   Jimenez Mena L R ^a   Lozano Cuenca, J ^a   Sanchez Lopez A ^a   Centurion D ^a   Mehrotra, S ^b   MaassenVanDenBrink, A ^b   Villalon C M ^a,b  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

CGRP; 5 HT 1B receptors; Capsaicin; Donitriptan; External carotid artery; Migraine; Sumatriptan; Vasodilatation

Indexed keywords

1 [2 [4 (4 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N METHYLISOCHROMAN 6 CARBOXAMIDE; 2,3,6,7 TETRAHYDRO 1' METHYL 5 [[2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL) 4 BIPHENYLYL]CARBONYL]SPIRO[FURO[2,3 F]INDOLE 3,4' PIPERIDINE]; 3 [4 (3 CHLOROPHENYL) 1 PIPERAZINYL] 1,1 DIPHENYL 2 PROPANOL; ACETYLCHOLINE; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; DONITRIPTAN; LIPID; PENTOBARBITAL; PNU 142633; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SODIUM CHLORIDE; SUMATRIPTAN SUCCINATE; UNCLASSIFIED DRUG; WATER;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CALIBRATION; CANNULA; CAROTID ARTERY FLOW; CAROTID ARTERY LIGATION; COMMON CAROTID ARTERY; CONTROLLED STUDY; DOG; DOPPLER FLOWMETER; DOSE RESPONSE; DRUG EFFECT; DRUG INFUSION; DRUG MECHANISM; DRUG SOLUBILITY; EXTERNAL CAROTID ARTERY; FEMORAL ARTERY; HEART RATE; INHIBITION KINETICS; INTERNAL CAROTID ARTERY; LIPID SOLUBILITY; MECHANICAL PROBE; NERVE SURGERY; NONHUMAN; PRESSURE TRANSDUCER; PRIORITY JOURNAL; THYROID GLAND; VAGUS NERVE; VASODILATATION;

ACETYLCHOLINE; ANIMALS; BENZOPYRANS; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; CAROTID ARTERY, EXTERNAL; CHROMANS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMODYNAMIC PROCESSES; HUMANS; INFUSIONS, INTRAVENOUS; NITRILES; PHENYLEPHRINE; PIPERAZINES; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT1D; SEROTONIN AGONISTS; SUMATRIPTAN; TRYPTAMINES; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 33748059541     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706839     Document Type: Article

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