If current inhibition: Cellular basis and physiology

Advances in Cardiology

Volumn 43, Issue , 2006, Pages 17-30

  Mangoni, M E ^a   Marger, L ^a   Nargeot, J ^a  

^a INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAZEPINE DERIVATIVE; CARDIOTONIC AGENT; ION CHANNEL; IVABRADINE;

ANIMAL; CARDIOVASCULAR DISEASE; DIASTOLE; DRUG EFFECT; HEART MUSCLE CONDUCTION SYSTEM; HEART RATE; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; BENZAZEPINES; CARDIOTONIC AGENTS; CARDIOVASCULAR DISEASES; DIASTOLE; HEART CONDUCTION SYSTEM; HEART RATE; HUMANS; ION CHANNELS;

EID: 33747876092     PISSN: 00652326     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000095403     Document Type: Review

References (66)

1. Baruscotti M, Bucchi A, Difrancesco D: Physiology and pharmacology of the cardiac pacemaker ('funny') current. Pharmacol Ther 2005;107:59-79.
2. f current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease. Drugs 2004;64:1757-1765.
3. Simon L, Ghaleh B, Puybasset L, Giudicelli JF, Berdeaux A: Coronary and hemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs. J Pharmacol Exp Ther 1995;275:659-666.
4. Colin P, Ghaleh B, Hittinger L, Monnet X, Slama M, Giudicelli JF, Berdeaux A: Differential effects of heart rate reduction and β-blockade on left ventricular relaxation during exercise. Am J Physiol 2002;282:H672-H679.
5. Vilaine JP, Bidouard JP, Lesage L, Reure H, Peglion JL: Anti-ischemic effects of ivabradine, a selective heart rate-reducing agent, in exercise-induced myocardial ischemia in pigs. J Cardiovasc Pharmacol 2003;42:688-696.
6. Colin P, Ghaleh B, Monnet X, Su J, Hittinger L, Giudicelli JF, Berdeaux A: Contributions of heart rate and contractility to myocardial oxygen balance during exercise. Am J Physiol 2003;284:H676-H682.
7. Thollon C, Cambarrat C, Vian J, Prost JF, Peglion JL, Vilaine JP: Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. Br J Pharmacol 1994;112:37-42.
8. Accili EA, Proenza C, Baruscotti M, DiFrancesco D: From funny current to HCN channels: 20 years of excitation. News Physiol Sci 2002;17:32-37.
9. DiFrancesco D: A study of the ionic nature of the pace-maker current in calf Purkinje fibres. J Physiol 1981;314:377-393.
10. DiFrancesco D: A study of the ionic nature of pacemaker current in calf Purkinje fibers. J Physiol 1981;314:377-393.
11. f) to generation of spontaneous activity in rabbit sino-atrial node myocytes. J Physiol 1991;434:23-40.
12. f) in cells isolated from the rabbit sino-atrial node. J Physiol 1986;377:61-88.
13. f) induced by acetylcholine in rabbit sino-atrial node myocytes. J Physiol 1988;405:477-491.
14. DiFrancesco D, Tortora P: Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature 1991;351:145-147.
15. f) by cAMP in the rabbit sino-atrial node. J Physiol 1994;474:473-482.
16. Barbuti A, Gravante B, Riolfo M, Milanesi R, Terragni B, DiFrancesco D: Localization of pacemaker channels in lipid rafts regulates channel kinetics. Circ Res 2004;94:1325-1331.
17. DiFrancesco D: Pacemaker mechanisms in cardiac tissue. Annu Rev Physiol 1993;55:455-472.
18. f) in isolated mouse sino-atrial cells. Cardiovasc Res 2001;52:51-64.
19. +, UL-FS-49, and ZD-7288 within sinoatrial node. Am J Physiol 1997;272:H2782-H2792.
20. Hoppe UC, Beuckelmann DJ: Characterization of the hyperpolarization- activated inward current in isolated human atrial myocytes. Cardiovasc Res 1998;38:788-801.
21. Yu H, Chang F, Cohen IS: Pacemaker current exists in ventricular myocytes. Circ Res 1993;72:232-236.
22. f, in ventricular myocytes from human failing heart. Circulation 1997;95:568-571.
23. Cerbai E, Giotti A, Mugelli A: Characteristics of L-type calcium channel blockade by lacidipine in guinea-pig ventricular myocytes. Br J Pharmacol 1997;120:667-675.
24. f in human isolated atrial myocytes. Cardiovasc Res 1998;40:516-522.
25. f) in human atrial cells: implications for atrial arrhythmias. Cardiovasc Res 1998;38:537-540.
26. Hoppe UC, Jansen E, Sudkamp M, Beuckelmann DJ: Hyperpolarization- activated inward current in ventricular myocytes from normal and failing human hearts. Circulation 1998;97:55-65.
27. Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR: Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell 1998;93:717-729.
28. Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M: A family of hyperpolarization-activated mammalian cation channels. Nature 1998;393:587-591.
29. Seifert R, Scholten A, Gauss R, Mincheva A, Lichter P, Kaupp UB: Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proc Natl Acad Sci USA 1999;96:9391-9396.
30. Ludwig A, Zong X, Stieber J, Hullin R, Hofmann F, Biel M: Two pacemaker channels from human heart with profoundly different activation kinetics. EMBO J 1999;18:2323-2329.
31. Vaccari T, Moroni A, Rocchi M, Gorza L, Bianchi ME, Beltrame M, DiFrancesco D: The human gene coding for HCN2, a pacemaker channel of the heart. Biochim Biophys Acta 1999;1446:419-425.
32. Kaupp UB, Seifert R: Molecular diversity of pacemaker ion channels. Ann Rev Physiol 2001;63:235-257.
33. Xue T, Marban E, Li RA: Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: insights into structure-function relationships and multimenzation. Circ Res 2002;90:1267-1273.
34. Ludwig A, Zong X, Hofmann F, Biel M: Structure and function of cardiac pacemaker channels. Cell Physiol Biochem 1999;9:179-186.
35. Viscomi C, Altomare C, Bucchi A, Camatini E, Baruscotti M, Moroni A, DiFrancesco D: C terminus-mediated control of voltage and cAMP gating of hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem 2001;276:29930-29934.
36. Moroni A, Barbuti A, Altomare C, Viscomi C, Morgan J, Baruscotti M, DiFrancesco D: Kinetic and ionic properties of the human HCN2 pacemaker channel. Pflugers Arch 2000;439:618-626.
37. Altomare C, Bucchi A, Camatini E, Baruscotti M, Viscomi C, Moroni A, DiFrancesco D: Integrated allosteric model of voltage gating of HCN channels. J Gen Physiol 2001;117:519-532.
38. Yu H, Wu J, Potapova I, Wymore RT, Holmes B, Zuckerman J, Pan Z, Wang H, Shi W, Robinson RB, El-Maghrabi MR, Benjamin W, Dixon J, McKinnon D, Cohen IS, Wymore R: MinK-related peptide 1: a β subunit for the HCN ion channel subunit family enhances expression and speeds activation. Circ Res 2001;88:E84-E87.
39. Qu J, Kryukova Y, Potapova IA, Doronin SV, Larsen M, Krishnamurthy G, Cohen IS, Robinson RB: MiRP1 modulates HCN2 channel expression and gating in cardiac myocytes. J Biol Chem 2004;279:43497-43502.
40. Shi W, Wymore R, Yu H, Wu J, Wymore RT, Pan Z, Robinson RB, Dixon JE, McKinnon D, Cohen IS: Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circ Res 1999;85:e1-e6.
41. Marionneau C, Couette B, Liu J, Li H, Mangoni ME, Nargeot J, Lei M, Escande D, Demolombe S: Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. J Physiol 2005;562:223-234.
42. f. J Biol Chem 2001;276:29233-29241.
43. James TN: Structure and function of the sinus node, AV node and his bundle of the human heart. 2. Function. Prog Cardiovasc Dis 2003;45:327-360.
44. Stieber J, Herrmann S, Feil S, Loster J, Feil R, Biel M, Hofmann F, Ludwig A: The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci USA 2003;100:15235-15240.
45. Moorman AF, de Jong F, Denyn MM, Lamers WH: Development of the cardiac conduction system. Circ Res 1998;82:629-644.
46. Mery A, Aimond F, Menard C, Mikoshiba K, Michalak M, Puceat M: Initiation of embryonic cardiac pacemaker activity by inositol 1,4,5-trisphosphate- dependent calcium signaling. Mol Biol Cell 2005;16:2414-2423.
47. Boyett MR, Honjo H, Kodama I: The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc Res 2000;47:658-687.
48. f in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cells. Proc Biol Sci 1992;250:199-207.
49. Thollon C, Bidouard JP, Cambarrat C, Lesage L, Reure H, Delescluse I, Vian J, Peglion JL, Vilaine JP: Stereospecific in vitro and in vivo effects of the new sinus node inhibitor (+)-S 16257. Eur J Pharmacol 1997;339:43-51.
50. h) in a zebrafish mutant with a slow heart rate. Proc Natl Acad Sci USA 1997;94:4554-4559.
51. Rosen MR, Brink PR, Cohen IS, Robinson RB: Genes, stem cells and biological pacemakers. Cardiovasc Res 2004;64:12-23.
52. f and undermines spontaneous beating of neonatal cardiomyocytes. Circulation 2003;107:485-489.
53. Qu J, Plotnikov AN, Danilo P Jr, Shlapakova I, Cohen IS, Robinson RB, Rosen MR: Expression and function of a biological pacemaker in canine heart. Circulation 2003;107:1106-1109.
54. Plotnikov AN, Sosunov EA, Qu J, Shlapakova IN, Anyukhovsky EP, Liu L, Janse MJ, Brink PR, Cohen IS, Robinson RB, Danilo P Jr, Rosen MR: Biological pacemaker implanted in canine left bundle branch provides ventricular escape rhythms that have physiologically acceptable rates. Circulation 2004;109:506-512.
55. Brown HF, DiFrancesco D, Noble SJ: How does adrenaline accelerate the heart? Nature 1979;280:235-236.
56. DiFrancesco D, Ducouret P, Robinson RB: Muscarinic modulation of cardiac rate at low acetylcholine concentrations. Science 1989;243:669-671.
57. DiFrancesco D: The onset and autonomic regulation of cardiac pacemaker activity: relevance of the f current. Cardiovasc Res 1995;29:449-456.
58. Schulze-Bahr E, Neu A, Friederich P, Kaupp UB, Breithardt G, Pongs O, Isbrandt D: Pacemaker channel dysfunction in a patient with sinus node disease. J Clin Invest 2003;111:1537-1545.
59. Milanesi R, Baruscotti M, Gnecchi-Ruscone T, DiFrancesco D: Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel. N Engl J Med 2006;354:151-157.
60. Bois P, Bescond J, Renaudon B, Lenfant J: Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells. Br J Pharmacol 1996;118:1051-1057.
61. f channels by ivabradine. J Gen Physiol 2002;120:1-13.
62. f in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors. Circulation 1993;88:2389-2401.
63. f) in sino-atrial node myocytes. Pflugers Arch 1994;427:64-70.
64. + channel diversity in the mammalian myocardium. J Physiol 2000;525:285-298.
65. 2+ channels in cardiac pacemaker activity. Proc Natl Acad Sci USA 2003;100:5543-5548.
66. 2+ channels. Circ Res 2006;98:1422-1430.