Characteristics of L-type calcium channel blockade by lacidipine in guinea-pig ventricular myocytes

British Journal of Pharmacology

Volumn 120, Issue 4, 1997, Pages 667-675

  Cerbai, Elisabetta ^a   Giotti, Alberto ^a   Mugelli, Alessandro ^a,b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Department of Pharmacology ^*  (Italy)

Author keywords

L type calcium current; Lacidipine; Nimodipine; Nisoldipine; Patch clamp; Sodium current; Ventricular myocytes

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; LACIDIPINE; NIMODIPINE; NISOLDIPINE; POTASSIUM ION; SODIUM ION;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; ELECTRIC POTENTIAL; GUINEA PIG; HEART MUSCLE CELL; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SODIUM CURRENT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CELLS, CULTURED; DIHYDROPYRIDINES; GUINEA PIGS; HEART; HEART VENTRICLES; MYOCARDIUM; NIMODIPINE; NISOLDIPINE; PATCH-CLAMP TECHNIQUES;

EID: 0031039867     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700951     Document Type: Article

References (32)

1. BEAN, B.P. (1984). Nitrendipine block of cardiac calcium channel: high affinity binding 10 the inactivated state. Proc. Natl. Acad. Sci. U.S.A., 81, 6388-6392.
2. BROWN, A.M., KUNZE, D.L. & YATANI, A. (1986). Dual effects of dihydropyridines on whole cell and unitary currents in single ventricular cells of guinea-pig. J. Physiol., 379, 495-514.
3. BURGES, R.A., GARDINER, D.G., GWILT, M., HIGGINS, A.J., BLACKBURN, K.J., CAMPBELL, S.F., CROSS, P.E. & STUBBS, J.K. (1987). Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors. J. Cardiovasc. Pharmacol., 9, 110-119.
4. CARPI, C., GAVIRAGHI, G. & SEMERARO, C. (1986). GX 1048 (GR 43659X), a new dihydropyridine calcium antagonist with potent and long-lasting antihypertensive action. Br. J. Pharmacol., 89, 758P.
5. 2+ channel antagonists. Trends Pharmacol. Sci., 13, 256-262.
6. CERBAI, E., AMBROSIO, G., PORCIATTI, F., CHIARIELLO, M., GIOTTI, A & MUGELLI, A. (1991). Cellular electrophysiological basis for oxygen radical-induced arrhythmias: a patch-clamp study in guinea-pig ventricular myocytes. Circulation, 84, 1773-1782.
7. CERBAI, E., DE BONFIOLI CAVALCABÒ, P., MASINI, I., VISENTIN, S., GIOTTI, A. & MUGELLI, A. (1990). Cardiac electrophysiology of a new calcium antagonist, lacidipine. J. Cardiovasc. Pharmacol., 15, 604-609.
8. CERBAI, E., GUERRA, L., VARANI, K., BOREA, P.A., BARBIERI, M. & MUGELLI, A. (1995). β-Adrenoceptor subtypes in young and old rat ventricular myocytes: a combined patch-clamp and binding study. Br. J. Pharmacol. 116, 1835-1842.
9. CHESTER, D.W., HERBETTE, L.G., MASON, R.P., JISLYN, A.F., TRIGGLE, D.J. & KOPPEL, D.E. (1987). Diffusion of dihydropyridine calcium channel antagonists in cardiac sarcolemmal lipid multibilayers. Biophys. J., 52, 1021-1030.
10. DATYNER, N.B. & COHEN, I.S. (1993). Slow inactivation of L-type calcium current distorts the measurement of L-type and T-type calcium current in Purkinje myocytes. J. Gen. Physiol., 102, 859-869.
11. GODFRAIND, T., EGLEME, C., FINET, M. & JAUMIN, P. (1987). The actions of nifedipine and nisoldipine on the contractile activity of human coronary arteries and human cardiac tissue in vitro. Pharmacol. Toxicol., 61, 79-84.
12. HERBETTE, L.G., GAVIRAGHI, G., TULENKO, T. & MASON, R.P. (1993). Molecular interaction between lacidipine and biological membranes. J. Hypertens., 11 (Suppl 1), S13-S19.
13. HERBETTE, L.G., PRESTON MASON, T. & TULENKO, T.N. (1994). Calcium antagonists and membrane binding - the unique properties of lacidipine. Res. Clin. Forums, 16, 17-28.
14. KAMP, T.J., SANGUINETTI, M.C. & MILLER, R.J. (1989). Voltage- and use-dependent modulation of cardiac calcium channels by the dihydropyridine (+)-202-791. Circ. Res., 64, 338-351.
15. KASS, R.S. & ARENA, J.P. (1988). Membrane potential and dihydropyridine block of calcium channels in the heart: influence of drug ionization on blocking activity. In The Calcium Channel: Structure, Function and implications, ed. Morad, M., Nayler, W., Kazda, S & Schramm, M. pp. 81-91. Berlin: Springer Verlag.
16. o on calcium channel block by amlodipine, a charged dihydropyridine compound: implications for location of the dihydropyridine receptor. J. Gen. Physiol., 93, 1109-1127.
17. KASS, R.S., ARENA, J.P. & CHIN, S. (1991). Block of L-type calcium channels by charged dihydropyridines: sensitivity to side of application and calcium. J. Gen. Physiol., 98, 63-75.
18. KWAN, Y.W., BANGALORE, R., LAKITSH, M., HARMUT, G. & KASS, R. (1995). Inhibition of cardiac L-type calcium channels by quaternary amlodipine: implications for pharmacokinetics and access to dihydropyridine binding sites. J. Mol. Cell. Cardiol., 27, 253-262.
19. LANGLEY, M.S., & SORKIN, E.M. (1989). Nimodipine: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cerebrovascular disease. Drugs. 37, 669-699.
20. LEE, K.S. & TSIEN, R.W. (1983). Mechanism of calcium channel blockade by verapamil, D-600, diltiazem and nitrendipine in single dialyzed heart cells. Nature, 302, 790-794.
21. MICHELI, D., COLLODEL, A., SEMERARO, C., GAVIRAGHI, G. & CARPI, C. (1990). Lacidipine: a calcium antagonist with potent and long-lasting antihypertensive effects in animal studies. J. Cardiovasc. Pharmacol., 15, 666-675.
22. MICHELI, D., RATTI, E., TOSON, G. & GAVIRAGHI, G. (1991). Pharmacology of lacidipine, a vascular selective calcium antagonist. J. Cardiovasc. Pharmacol., 17, (Suppl 4), S1-S8.
23. 2+ channel by photoaffinity labelling of diazepine. Proc. Natl. Acad. Sci. U.S.A., 88, 9203-9207.
24. NAYLER, W.G. (1988). Calcium Antagonists. London: Academic Press.
25. SANGUINETTI, M.C. & KASS, R.S. (1984). Voltage-dependent block of calcium channel current in the calf Purkinje fiber by dihydropyridine calcium channel antagonists. Circ. Res., 55, 336-348
26. SCHWARTZ, A , GRUPP, I.L., GRUPP, G., WILLIAMS, J.S. & VAGHY, P.L. (1984). Effects of dihydropyridine calcium channel modulators in the heart: pharmacological and radioligand binding correlations. Biochem. Biophys. Res. Commun., 25, 387-394.
27. 3H-azidopine within the alpha I subunit. Proc. Natl. Acad. Sci. U.S.A., 88, 10769-10773.
28. TRIGGLE, D.J. (1991). Calcium-channel drugs: structure-function relationships and selectivity of action. J. Cardiovasc. Pharmacol., 18 (Suppl. 10), S1-S6.
29. UEHARA, A. & HUME, J.R. (1985). Interactions of organic calcium channel antagonists with calcium channels in frog atrial cells. J. Gen. Physiol., 89, 621-647.
30. VAN ZWIETEN, P.A. & PFAFFENDORF, M. (1993). Similarities and differences between calcium antagonists: pharmacological aspects. J. Hypertens., 11 (Suppl. 1), S3-S11.
31. WEBER, M.A. & GRAETTINGER, W.F. (1994). Calcium channel blockers as hypotensive agents. In Cardiovascular Pharmacology and Therapeutics. ed. Singh, B.N., Dzau, V.J., Vanhoutte, P.M. & Woosley, R.L. pp. 931-944 New York: Churchill Livingston Inc.
32. YASUI, K. & PALADE, P. (1995). Inhibitory action of SR33557 on L-type calcium current in single ventricular myocytes of rat. Br. J. Pharmacol., 114, 468-474.