Metabolic activation of carcinogenic ethylbenzene leads to oxidative DNA damage

Chemico-Biological Interactions

Volumn 150, Issue 3, 2004, Pages 271-281

  Midorikawa, Kaoru ^a   Uchida, Takafumi ^b   Okamoto, Yoshinori ^b   Toda, Chitose ^b   Sakai, Yoshie ^b   Ueda, Koji ^b   Hiraku, Yusuke ^a   Murata, Mariko ^a   Kawanishi, Shosuke ^a   Kojima, Nakao ^b  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b MEIJO UNIVERSITY   (Japan)

Author keywords

Carcinogenesis; Copper; Ethylbenzene; Hydrogen peroxide; Metabolic activation; Oxidative DNA damage

Indexed keywords

1 PHENYLETHANOL; 2 ETHYLPHENOL; 4 ETHYLCATECHOL; 4 ETHYLPHENOL; 8 HYDROXYDEOXYGUANOSINE; ACETOPHENONE; BATHOCUPROINE; CARCINOGEN; CATALASE; CATECHOL DERIVATIVE; CHELATING AGENT; COPPER; DNA; DNA FRAGMENT; ETHYLBENZENE; ETHYLHYDROQUINONE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; METHANE; METHIONAL; PHENOL DERIVATIVE; PHOSPHORUS 32; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCING AGENT; SCAVENGER; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATTLE; CONTROLLED STUDY; DIHYDROXYLATION; DNA DAMAGE; EXPERIMENT; INHIBITION KINETICS; ISOTOPE LABELING; LIVER MICROSOME; MALE; METABOLISM; METABOLITE; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; RAT; THYMUS;

ANIMALS; BENZENE DERIVATIVES; CARCINOGENS; CATTLE; COPPER; DEOXYGUANOSINE; DNA DAMAGE; FREE RADICAL SCAVENGERS; HYDROQUINONES; MALE; MICROSOMES, LIVER; NAD; OXIDATION-REDUCTION; PHENANTHROLINES; PHENOLS; RATS; RATS, SPRAGUE-DAWLEY; THYMUS GLAND;

EID: 9244242017     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2004.09.020     Document Type: Article

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