Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy

Journal of Cardiovascular Pharmacology

Volumn 48, Issue 1, 2006, Pages 802-813

  Henning, Robert J ^a   Cuevas, Javier ^a   Ivancsits, Douglas ^a   Sanchez, Anthony ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

myosin heavy chain; Calcium; Calcium currents; Cardiomyopathy; Cardiovascular pharmacology; Intracellular calcium

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; CALCIUM ION; COCAINE; MYOSIN HEAVY CHAIN BETA; PHOSPHORUS 32; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE (CALCIUM,CALMODULIN) I; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE (CALCIUM,CALMODULIN) INHIBITOR; PROTEIN KINASE (CALCIUM,CALMODULIN) IV; SILVER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; COCAINE DEPENDENCE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MECHANISM; ELECTRIC POTENTIAL; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART CELL CULTURE; HEART HYPERTROPHY; HEART MUSCLE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; SARCOPLASMIC RETICULUM; SILVER STAINING; WESTERN BLOTTING;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ADENOSINE TRIPHOSPHATE; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM CHANNELS; CALCIUM SIGNALING; CELLS, CULTURED; COCAINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART VENTRICLES; HYPERTROPHY; MALE; MEMBRANE POTENTIALS; MYOCYTES, CARDIAC; MYOSIN HEAVY CHAINS; PATCH-CLAMP TECHNIQUES; PEPTIDES; PHENYLEPHRINE; PHOSPHORUS RADIOISOTOPES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SARCOLEMMA;

EID: 33747778323     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000211796.45281.46     Document Type: Article

References (45)

1. Boghdadi M, Henning RJ. Cocaine: pathophysiology and clinical toxicology. Heart Lung. 1997;26:466-483.
2. Brickner M, Areard J, Eichorn E. Left ventricular hypertrophy associated with cocaine use. Circ. 1991;84:1130-1135.
3. Willett DL, Brickner E, Gigarroa CG. Racial differences in the prevalence of left ventricular hypertrophy among chronic cocaine abusers. Am J Cardiol. 1995;76:937-940.
4. Henning RJ, Silva J, Reddy V, et al. Cocaine increases beta-myosin heavy chain protein expression in cardiac cardiomyocytes. J Cardiovascular Pharmacol Ther. 2000;5:313-322.
5. Henning RJ, Li Y. Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms. J Cardiovasc Pharmacol Ther. 2003;8:149-160.
6. 2+-dependent transgenic model of cardiac hypertrophy. Circulation. 2001;103:140-147.
7. 2+ in myocytes from aortic-banded rats. Circulation. 1996;94:2915-2922.
8. 2+/calmodulin-dependent protein kinase II in vivo. Mol Endocrinol. 2003;17:183-192.
9. 2+ current in rabbit ventricular myocytes. Circ Res. 1994;75:854-861.
10. Dzhura I,Wu Y, Colbran RJ, et al. Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels. Nat Cell Biol. 2000;2:173-177.
11. Wu Y, Temple J, Zhang R, et al. Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation. 2002;106;1288-1293.
12. 2+ handling. Circ Res. 2003;92:904-911.
13. 2+/calmodulin- dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res. 2004;94:e61-e70.
14. Witcher DR, Kovacs RJ, Schulman H, et al. Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity. J Biol Chem. 1991;266:11144-11152.
15. Passier R, Zeng H, Frey N, et al. CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo. J Clin Invest. 2000;105:1395-1406.
16. Kato T, Sano M, Miyoshi S, et al. Calmodulin kinase II and IV and calcineurin are involved in leukemia inhibitory-induced cardiac hypertrophy in rats. Circ Res. 2000;87:937-945.
17. Claycomb WC, Lanson N Jr. Isolation and culture of the terminally differentiated adult mammalian ventricular cardiac muscle cell. In Vitro. 1984;20:647-651.
18. He Q, Cahill CJ, Siro MJ. Suspension culture of differentiated rat heart cardiomyocytes on non-adhesive surfaces. J Mol Cell Cardiol. 1996;8:1177-1186.
19. Zhu W, Zou Y, Shiogjima I, et al. Ca2+/calmodulin-dependent kinase II and calcinuerin play critical roles in endothelin-induced cardiomyocyte hypertrophy. J Biol Chem. 2000;275:15239-15245.
20. Miyano O, Kameshita I, Fujisawa H. Purification and characterization of a brain-specific multifunctional calmodulin-dependent protein kinase from rat cerebellum. J Bio Chem. 1992;267:1198-1203.
21. Gringhuis SI, de Leig LFMH, Wayman GA, et al. The Ca2+/calmodulin- dependent kinase IV is involved in the CD5-mediated-signaling pathway in human T lymphocytes. J Biol Chem. 1997;272:31809-31820.
22. Hidak H, Hagiwara M, Tokumitsu H. Novel and selective inhibitors of CaM-kinase II and other calmodulin-dependent enzymes. Adv Exp Med Biol. 1990;269:159-162.
23. Tokumitsu H, Chijiwa T, Hagiwara M, et al. KN-62 1-[N,O-Bis(5- isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II. J Biol Chem. 1990;265:4315-4320.
24. Piao S, Yu F, Mihm MJ, et al. A simplified method for identification of human cardiac myosin heavy-chain isoforms. Biotechnol Appl Biochem. 2003;37:27-30.
25. Reiser PJ, Kline WO. Electrophoretic separation and quantitation of cardiac myosin heavy chain isoforms in eight mammalian species. Am J Physiol. 1998;274(Heart Circ Physiol 43):1048-1053.
26. Reiser PJ, Portman MA, Ning X, et al. Human cardiac myosin heavy chain isoforms in fetal and failing adult atria and ventricles. Am J Physiol Heart Circ Physiol. 2001;280:1814-1820.
27. Rae J, Cooper K. Low resistance perforated patch recordings with amphotericin B. J Neurosci. 1991;37:15-26.
28. DeHaven WI, Cuevas J. VPAC receptor modulation of neuroexcitability in intracardiac neurons: dependence on intracellular calcium mobilization and synergistic enhancement by PAC1 receptor activation. J Biol Chem. 2004;279:40609-40621.
29. Besse KS, Assayag P, Latour CL. Molecular characteristics of cocaine-induced cardiomyopathy in rats. Eur J Pharmacol. 1997;338:123-129.
30. Chakko S, Fernandez A, Mellman T, et al. Cardiac manifestations of cocaine abuse: a cross-sectional study of asymptomatic men with a history of long-term abuse of "crack cocaine". J Am Col Cardiol. 1992;20:1168-1174.
31. Geenen D, Mahotra A, Scheuer J, et al. Repeated catecholamine surges alter cardiac isomyosin expression but not protein synthesis in the rat heart. J Mol Cell Cardiol. 1997;29:2711-2716.
32. Zhang T, Johnson EN, Gu Y, et al. The cardiac-specific nuclear δB isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. J Biol Chem. 2002;277:1261-1267.
33. Zhang T, Maier LS, Dalton ND, et al. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res. 2003;92:912-919.
34. Srnivasan M, Edman CF, Schulman H. Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus. J Cell Biol. 1994;126:839-852.
35. Hoch B, Meyer R, Hetzer R, et al. Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin dependent protein kinase in failing and nonfailing human myocardium. Circ Res. 1999;84:713-721.
36. Kirchhefer U, Schmitz W, Scholz H, et al. Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts. Cardiovasc Res. 1999;42:254-261.
37. Zhang T, Miyamoto S, Brown JH. Cardiomyocyte calcium and calcium/calmodulin-dependent protein kinase II: friends or foe? Recent Prog Hormone Res. 2004;59:141-168.
38. Ramirez MT, Zhao X-L, Schulman H, et al. The nuclear deltaB isoform of Ca2+/calmodulin dependent protein kinase II regulates atrial natriuretic factor gene expression in ventricular cardiomyocytes. J Bio Chem. 1997;272:31203-31208.
39. Hanson PI, Schulman H. Inhibitory autophosphorylation of multifunctional Ca2+/calmodulin dependent protein kinase analyzed by site directed mutagenesis. J Bio Chem. 1992;267:17216-17224.
40. Lindemann JP, Watanabe AM. Phosphorylation of phospholamban in intact myocardium. Role of Ca2+-calmodulin-dependent mechanisms. J Biol Chem. 1985;260:4516-4525.
41. 2+-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science. 1991;252:1427-1430.
42. 2+/calmodulin- dependent protein kinases type I, II and IV. J Biol Chem. 1996;271:3066-3073.
43. Welder AA, Grammas P, Melchert RB. Cellular mechanisms of cocaine cardiotoxicity. Toxicol Lett. 1993;69:227-238.
44. Premkumar LS. Selective potentiation of L-type calcium channel currents by cocaine in cardiac myocytes. Mol Pharm. 1999;56:1138-1142.
45. ++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Therp. 1998;287:996-1006.