Cocaine increases β-myosin heavy-chain protein expression in cardiac myocytes

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 5, Issue 4, 2000, Pages 313-322

  Henning, Robert J ^a   Silva, Jose ^b   Reddy, Vijaya ^b   Kamat, Seema ^b   Morgan, Michael B ^a   Li, Yong Xiang ^a   Chiou, Shirley ^b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cardiac hypertrophy; Cardiac myocytes; Cocaine; Myosin; Ventricular hypertrophy; myosin heavy chain protein

Indexed keywords

COCAINE; MYOSIN HEAVY CHAIN; NORADRENALIN;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; BETA CHAIN; CONTROLLED STUDY; DRUG EFFECT; HEART MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT;

ANIMALS; CARDIOMEGALY; CELL CULTURE TECHNIQUES; COCAINE; DOPAMINE UPTAKE INHIBITORS; MALE; MYOCARDIUM; MYOSIN HEAVY CHAINS; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033761690     PISSN: 10742484     EISSN: None     Source Type: Journal    
DOI: 10.1054/JCPT.2000.19331     Document Type: Article

References (59)

1. Left ventricular hypertrophy associated with cocaine use
2. Cardiac manifestations of cocaine abuse
3. Racial differences in the prevalence of left ventricular hypertrophy among chronic cocaine abusers
4. Cocaine: Pathophysiology and clinical toxicology
5. Molecular characteristics of cocaine-induced cardiomyopathy in rats
6. Cardiovascular hypertrophy and increased vascular contractile responsiveness following repeated cocaine injection in rabbits
7. Left ventricular hypertrophy: A pressure-independent cardiovascular risk factor
8. Signaling pathways for cardiac hypertrophy and failure
9. Molecular regulation of cardiac myocyte hypertrophy
10. Transcription of early developmental isogenes in cardiac myocyte hypertrophy
11. 1-Adrenergic stimulation of rat myocardial cells increases protein synthesis
12. 1-adrenergic response
13. Changes in gene expression in the intact human heart. Downregulation of α-myosin heavy chain in hypertrophied, failing ventricular myocardium
14. The existence of fetal type myosin heavy chain in the human heart and its abnormal expression in the ventricles of dilated cardiomyopathy
15. Reversible alterations in myocardial gene expression in the failing and nonfailing human heart
16. Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines
17. Suspension culture of differentiated rat heart myocytes on non-adhesive surfaces
18. Cardiac muscle cell proliferation and cell differentiation in vivo and in vitro
19. Culture of terminally differentiated ventricular cardiac muscle cell. Characterization of exogenous substrate oxidation and adenylate cyclase system
20. Isolated cardiac myocytes. II. Functional aspects of mature cells
21. Isolation and culture of the terminally differentiated adult mammalian cardiac muscle cell
22. Culture of the terminally differentiated adult cardiac muscle cell: A light and scanning electron microscope study
23. Long-term culture and characterization of the adult ventricular and atrial cardiac muscle cell
24. Long-term cell culture of adult mammalian cardiac myocytes: Electron microscopic and immunofluorescent analyses of myofibrillar structure
25. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
26. Visualization of cardiac ventricular myosin heavy chain homodimers and heterodimers by monoclonal antibody epitope mapping
27. Fractionation and characterization of two molecular variants of myosin from adult human atrium
28. Alpha-adrenergic receptors on rat ventricular myocytes: Characteristics and linkage to cAMP metabolism
29. Catecholamines modulate protein turnover in cultured, quiescent rabbit cardiac myocytes
30. 1-adrenergic receptor hypertrophy of cultured rat heart myocytes
31. Regulation of hypertrophy and atrophy in cultured adult heart cells
32. Myosin isoenzymic changes in several models of rat cardiac hypertrophy
33. 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating
34. Various hypertrophic stimuli induce distinct phenotypes in cardiomyocytes
35. Regulation of growth in the adult cardiomyocytes
36. Cellular mechanisms of cardiac hypertrophy
37. Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene
38. Cocaine alters myosin isoform expression in rat soleus
39. Repeated catecholamine surges alter cardiac isomyosin expression but not protein synthesis in the rat heart
40. Selective potentiation of L-type calcium channel currents by cocaine in cardiac myocytes
41. Cocaine binding at sigma receptors
42. Cocaine increases the release of immunoreactive endothelin. Reversal by coincubation with sigma receptor antagonists
43. 2+ influx, and beating in cultured cardiac myocytes
44. Sigma receptor ligands elevate inositol 1,4,5 triphosphate production in rat cardiac myocytes
45. Acute cocaine results in rapid rises in intracellular free calcium concentration in canine smooth muscle cells
46. Effect of cocaine on calcium mobilization in cultured rat myocardial cells
47. Effect of cocaine on intracellular calcium regulation in myometrium from pregnant women
48. Regulation of ERK, part of the neurotrophin signal transduction cascade, in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine
49. Early response kinase and PI 3-kinase activation in adult cardiomyocytes and their role in hypertrophy
50. A calcinuerin-dependent transcriptional pathway for cardiac hypertrophy
51. Exogenous effect and endogenous production of endothelin in cardiac myocytes: Potential significance in heart failure
52. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes
53. Increased in-vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemia
54. Endothelin-1 induces hypertrophy with enhanced expression of muscle specific genes in cultured neonatal rat cardiomyocytes
55. Various hypertrophic stimuli induce distinct phenotypes in cardiomyocytes
56. Signaling in myocardial hypertrophy. Life after calcineurin?
57. Positive regulation of the skeletal alpha-actin gene by Fos and Jun in cardiac myocytes
58. Role of protein kinase system in the signal transduction of stretch-mediated protooncogene expression and hypertrophy of cardiac myocytes