ApoE gene and familial risk of Alzheimer's disease as predictors of odour identification in older adults

Neurobiology of Aging

Volumn 27, Issue 10, 2006, Pages 1425-1430

  Handley, Olivia J ^a   Morrison, Catriona M ^b   Miles, Christopher ^a   Bayer, Antony J ^c  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Aging; Alzheimer's disease; ApoE; Cognitive impairment; Olfaction

Indexed keywords

APOLIPOPROTEIN E;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; FAMILIAL DISEASE; FEMALE; GENOTYPE; HETEROZYGOTE DETECTION; HUMAN; MALE; ODOR; PRIORITY JOURNAL; RISK FACTOR; SAMPLE; SMELLING;

AGE FACTORS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; COMORBIDITY; FAMILY; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GREAT BRITAIN; HETEROZYGOTE; HUMANS; MALE; MIDDLE AGED; OLFACTION DISORDERS; PREVALENCE; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; RISK FACTORS; SENSITIVITY AND SPECIFICITY;

EID: 33747757649     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2005.08.001     Document Type: Article

References (47)

1. Allen S.J. Alzheimer's disease: past, present, and future themes. In: Dawbarn D., and Allen S.J. (Eds). Neurobiology of Alzheimer's disease. 2nd ed. (2001), OUP, Oxford 1-32
2. Bacon A.W., Bondi M.W., Salmon D.P., and Murphy C. Very early changes in olfactory functioning due to Alzheimer's disease and the role of apolipoprotein E in olfaction. Ann NY Acad Sci 855 (1998) 723-731
3. Berg L., McKeel D.W., Miller J.P., Storandt M., Rubin E.H., Morris J.C., et al. Clinicopathological studies in cognitively healthy aging and Alzheimer disease: relation of histologic markers to dementia severity, age, sex, and Apolipoprotein E genotype. Arch Neurol 55 (2003) 326-335
4. Berr C., Lambert J.C., Sazdovitch V., Amouyel P., Chartier-Harlin M.C., Mohr M., et al. Neuropathological epidemiology of cerebral aging: a study of two genetic polymorhisms. Neurobiol Aging 22 (2001) 227-235
5. Bondi M.W., Monsch A.U., Galasko D., Butters N., Salmon D.P., and Delis D.C. Preclinical cognitive markers of dementia of the Alzheimer type. Neuropsychology 8 (1994) 374-384
6. Boss M.A. Diagnostic approaches to Alzheimer's disease. Biochim Biophys Acta 1502 (2000) 188-200
7. Braak H., and Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82 (1991) 239-259
8. Corder E.H., Saunders A.M., Risch N.J., Strittmatter W.J., Schmechel D.E., Gaskell PCJ, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer's disease. Nat Gen 7 (1994) 180-184
9. Devanand D.P., Michaels-Marston K.S., Liu X., Pelton G.H., Padilla M., Marder K., et al. Olfactory deficits in patients with mild cognitive impairment predict Alzheimer's disease at follow-up. Am J Psychiatry 157 (2000) 1399-1405
10. Doty R.L. Odour perception in neurodegenerative diseases. In: Doty R.L. (Ed). Handbook of olfaction and gustation. 2nd ed. (2003), Marcel Dekker, NY 479-503
11. Eichenbaum H., Morton T.H., Potter H., and Corkin S. Selective olfactory deficits in case HM. Brain 106 (1983) 459-472
12. Folstein M.F., Folstein S., and McHugh P.R. Mini-Mental State Exam: a practical method for grading the status of patients for clinicians. J Psychiatr Res 12 (1975) 189-198
13. Fox N.C., Warrington E.K., Seiffer A.L., Agnew S.K., and Rossor M.N. Presymptomatic cognitive deficits in individuals at risk of familial Alzheimer's disease. Brain 121 (1998) 1631-1639
14. Gilbert P., and Murphy C. The effect of the ApoE epsilon4 allele on recognition memory for olfactory and visual stimuli in patients with pathologically confirmed Alzheimer's disease, probable Alzheimer's disease, and healthy elderly controls. J Clin Exp Neuropsychol 26 (2004) 779-794
15. Gilbert PE, Barr PJ, Murphy C. Differences in olfactory and visual memory in patients with pathologically confirmed Alzheimer's disease and the Lewy body variant of Alzheimer's disease. J Int Neuropsychol Soc 2004;10:835-42.
16. Graves A.B., Bowen J.D., Rajaram L., McCormick W.C., McCurry S.M., Schellenberg G.D., et al. Impaired olfaction as a marker for cognitive decline: interaction with apolipoprotein E epsilon4 status. Neurology 53 (1999) 1480-1487
17. Hardy J. New insights into the genetics of Alzheimer's disease. Trends Mol Med 28 (1996) 255-258
18. Hixson J.E., and Vernier D.T. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hhal. J Lipid Res 31 (1990) 545-548
19. Kim K.W., Younm J.C., Lee D.Y., Lee K.U., Lee J.H., and Woo J.I. Apolipoprotein E e4 allele is not associated with the cognitive impairment in community-dwelling normal elderly individuals. Int J Geriatr Psychiatry 17 (2002) 635-640
20. Kovács T., Cairns N.J., and Lantos P.L. Amyloid deposition and neurofibrilliary tangle formation in the olfactory bulb in ageing and Alzheimer's disease. Neuropathol Appl Neurobiol 25 (1999) 481-491
21. Larsson M., Finkel D., and Pedersen N.L. Odor identification: Influences of age, gender, cognition, and personality. J Gerontol 55B (2000) P304-P310
22. Mahley R.W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240 (1988) 622-630
23. Mayeux R., Small S.A., Tang M.-X., Tycko B., and Stern Y. Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E. Neurobiol Aging 22 (2001) 683-689
24. McKhann G., Drachman D., Folstein M., Katzman R., Price D., and Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34 (1984) 939-944
25. Mesholam R.I., Moberg P.J., Mahr R.N., and Doty R.L. Olfaction in neurodegenerative disease. Arch Neurol 55 (1998) 84-90
26. Morgan C.D., Nordin S., and Murphy C. Odour identification as an early marker for Alzheimer's disease: Impact of lexical functioning and detection sensitivity. J Clin Exp Neuropsychol 17 (1995) 793-803
27. Murphy C. Loss of olfactory function in dementing disease. Physiol Behav 66 (1999) 177-182
28. Murphy C., Bacon A.W., Bondi M., and Salmon D.P. Apolipoprotein E status is associated with odour identification deficits in nondemented older persons. Ann NY Acad Sci 855 (1998) 744-750
29. Murphy C., Schubert C.R., Cruickshanks K.J., Klein BEK, Klein R., and Nondahl D.M. Prevalence of olfactory impairment in older adults. J Am Med Assoc 288 (2002) 2307-2312
30. Nicolli-Waller C., Harvey J., Nordin S., and Murphy C. Remote odour memory in Alzheimer's disease: deficits as measured by familiarity. J Adult Dev 6 (1999) 131-137
31. Nilsson L., Nyberg L., and Bäckman L. Genetic variation in memory functioning. Neurosci Biobehav Rev 26 (2002) 841-848
32. Ohm T.G., Kirca M., Bohl J., Scharnagl H., Groß W., and März W. Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation. Neuroscience 66 (1995) 583-587
33. Ott A., Breteler M.M.B., van Harskamp F., Claus J.J., van der Cammen T.J.M., Grobbee D.E., et al. Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study. Br Med J 31 (1995) 970-973
34. Pericak-Vance M., Grubber J., Bailey L.R., Hedges D., West S., Santoro L., et al. Identification of novel genes in late-onset Alzheimer's disease. Exp Gerontol 35 (2000) 1343-1352
35. Pericak-Vance M., Bebout J.L., Gaskell J., Yamaoka L.H., Hung W.Y., Alberts M.J., et al. Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. Am J Hum Genet 48 (1991) 1034-1050
36. Peters J.M., Hummel T., Kratzsch T., Lotsch J., Skarke C., and Frolich L. Olfactory function in mild cognitive impairment and Alzheimer's disease: an investigation using psychophysical and electrophysiological techniques. Am J Psychiatry 160 (2004) 1995-2002
37. Rice F., Abraham R., Rudruasingham V., Owen M.J., and Williams J. Memory for new information as a cognitive marker of liability to Alzheimer's disease in a high risk group: research note. Int J Geriatr Psychiatry 18 (2003) 155-160
38. Schiffman S.S., Graham B.G., Sattely-Miller E.A., Zervakis J., and Welsh-Bohmer K. Taste, smell and neuropsychological performance of individuals at familial risk for Alzheimer's disease. Neurobiol Aging 23 (2002) 397-404
39. Schmechel D.E., Saunders A.M., Strittmatter W.J., Crain B.J., Hulette C.M., Joo S.H., et al. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer's disease. Proc Natl Acad Sci USA 90 (1993) 9649-9653
40. Serby M., Mohan C., Aryan M., Williams L., Mohs R., and Davis K.L. Olfactory identification deficits in relatives of Alzheimer's disease patients. Biol Psychiatry 39 (1996) 375-377
41. Small B.J., Graves A.B., McEvoy C.L., Crawford F.C., Mullan M., and Mortimer J.A. Is ApoE-e4 a risk factor for cognitive impairment in normal aging?. Neurology 54 (2000) 2082-2088
42. Small G.W., Chen S.T., Komo S., Ercoli L., Bookheimer S., Miller K., et al. Memory self-appraisal in middle-aged and older adults with the apolipoprotein E-4 allele. Am J Psychiatry 156 (1999) 1035-1038
43. Smith G.E., Bohac D.L., Waring S.C., Kokmen E., Tangalos E.G., Ivnik R.J., et al. Apolipoprotein E genotype influences cognitive 'phenotype' in patients with Alzheimer's disease but not in healthy control subjects. Neurology 50 (1998) 355-362
44. Strittmatter W.J., Saunders A.M., Schmechel D., Pericak-Vance M., Enghild J., Salvesen G.S., et al. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 90 (1993) 1977-1981
45. Strittmatter W.J., Weisgraber K.H., Huang D.Y., Dong L., Salvesen G., Pericak-Vance M., et al. Binding of human apolipoprotein E to synthetic amyloid β peptide: isoform-specific effects and implications for late-onset Alzheimer's disease. Proc Natl Acad Sci USA 90 (1993) 8098-8102
46. van Dujin C.M., Clayton D., Chandra V., Fratiglioni L., Graves A., Heyman A., et al. Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. Int J Epidemiol 20 (1991) 13-S20
47. Wang Q.S., Tian L., Huang Y.L., Qin S., He L.Q., and Zhou J.N. Olfactory identification and apolipoprotein E epsilon 4 allele in mild cognitive impairment. Brain Res 951 (2002) 77-81