Impaired olfaction as a marker for cognitive decline: Interaction with apolipoprotein E ε4

Neurology

Volumn 53, Issue 7, 1999, Pages 1480-1487

  Graves, A Borenstein ^a,e   Bowen, J D ^b   Rajaram, L ^a   McCormick, W C ^b   McCurry, S M ^c   Schellenberg, G D ^d   Larson, E B ^b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Apolipoprotein E; Cognitive decline; Olfaction

Indexed keywords

APOLIPOPROTEIN E;

AGED; AGING; ALLELE; ALZHEIMER DISEASE; ANOSMIA; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMORY; PRIORITY JOURNAL; RISK ASSESSMENT; SMELLING;

EID: 0000954482     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.53.7.1480     Document Type: Article

References (38)

1. Feldman JI, Murphy C, Davidson TM, Jalowayski AA, de Jaime GG. The rhinologic evaluation of Alzheimer's disease. Laryngoscope 1991;101:1198-1202.
2. Serby M, Kalkstein D, Larson P. Olfaction and neuropsychiatry. In: Serby M, Chobor K, eds. The science of olfaction: olfaction and the central nervous system. New York: Springer-Verlag, 1992:559-584.
3. Souder E, Yoder L. Olfaction: the neglected sense. J Neurosci Nurs 1992;24:273-280.
4. Mesholam RI, Moberg PJ, Mahr RN, Doty RL. Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. Arch Neurol 1998;55:84-90.
5. Serby M, Larson P, Kalkstein D. The nature and course of olfactory deficits in Alzheimer's disease. Am J Psychiatry 1991;148:357-360.
6. Eichenbaum H, Morton TH, Potter H, Corkin S. Selective olfactory deficits in case H.M. Brain Res Bull 1983;18:597-600.
7. Huff FJ, Boller F, Lucchelli F, et al. The neurologic examination in patients with probable Alzheimer's disease. Arch Neurol 1987;44:1030-1032.
8. Doty RL. Olfactory capacities in aging and Alzheimer's disease. Psychosocial and anatomic considerations. Ann NY Acad Sci 1991;640:20-27.
9. Serby M, Mohan C, Aryan M, et al. Olfactory identification deficits in relatives of Alzheimer's disease patients. Biol Psychiatry 1996;39:375-377.
10. Nordin S, Murphy C. Impaired sensory and cognitive olfactory function in questionable Alzheimer's disease. Neuropsychology 1996;10:113-119.
11. Mortimer JA, Fortier I, Pepin EP, Gauvreau D. Sensory loss as a predictor of dementia and questionable dementia in a community of elderly persons. Neurobiol Aging 1996;17:S79. Abstract.
12. Graves AB, Larson EB, Edland SD, et al. Prevalence of dementia and its subtypes in the Japanese American population of King County, Washington state: the Kame Project. Am J Epidemiol 1996;144:760-771.
13. Teng EL, Hasegawa K, Homma A, et al. The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiologic studies of dementia. Int Psychogeriatr 1994;6:45-56.
14. Doty RL, Marcus A, Lee WW. Development of the 12-item Cross-Cultural Smell Identification Test (CC-SIT). Laryngoscope 1996;106:353-356.
15. Doty RL, Shaman P, Dann M. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav 1984;32:489-502.
16. Doty RL, Frye RE, Agrawal U. Internal consistency reliability of the fractionated and whole University of Pennsylvania Smell Identification Test. Percept Psychophysics 1989;45:381-384.
17. Doty DL. The Smell Identification Test administration manual. Haddon Heights, NJ: Sensonics, Inc., 1983.
18. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 1988;16:12-15.
19. Emi M, Wu LL, Robertson MA, et al. Genotyping and sequence analysis of apolipoprotein E isoforms. Genomics 1988; 3:373-377.
20. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res 1990;31:545-548.
21. Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
22. Graves AB, Larson EB, Kukull WA, White LR, Teng EL. Screening for dementia in the community in cross-national studies: comparison between the Cognitive Abilities Screening Instrument and the Mini-Mental State Examination. In: Corain B, Iqbal K, Nicolini B, Winblad B, Wisniewski H, Zatta P, eds. Alzheimer's disease: advances in clinical and basic research. New York: John Wiley & Sons, 1993:113-119.
23. Teng EL, Chui HC. The Modified Mini-Mental State (3MS) Examination. J Clin Psychiatr 1987;44:314-318.
24. Hasegawa K. The clinical assessment of dementia in the aged: a dementia screening scale for psychogeriatric patients. In: Bergener M, Lehr U, Lang E, Schmitz-Scherzer, eds. Aging in the eighties and beyond. New York: Springer, 1983:207-218.
25. Zar JH. Biostatistical analysis. 2nd ed. Englewood Cliffs, NJ: Prentice-Hall, 1984.
26. Schlesselman JJ. Case-control studies: design, conduct, analysis. New York: Oxford University Press, 1982.
27. Hosmer DW Jr, Lemeshow S. Applied logistic regression. New York: John Wiley & Sons, 1989.
28. Ottman R. An epidemiologic approach to gene-environment interaction. Genet Epidemiol 1990;7:177-185.
29. Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 1983;148:839-843.
30. Vida S. A computer program for non-parametric receiver operating characteristic analysis. Comput Methods Programs Biomed 1993;40:95-101.
31. Pearson RC. Cortical connections and the pathology of Alzheimer's disease. Neurodegeneration 1996;5:429-434.
32. Nordin S, Almquist O, Berglund B, Wahlund LO. Olfactory dysfunction for pyridine and dementia progression in Alzheimer's disease. Arch Neurol 1997;54:993-998.
33. Murphy C, Gilmore MM, Seery CS, Salmon DP, Lasker BR. Olfactory thresholds are associated with degree of dementia in Alzheimer's disease. Neurobiol Aging 1990;11:465-469.
34. Chiodo LK, Royall DR, Jaramillo CJ, Polk MJ. Olfactory function and cognition in independent elders. J Am Geriatr Soc 1998;46:S71. Abstract.
35. Koss E, Weiffenbach JM, Haxby JV, Friedland RP. Olfactory detection and identification performance are dissociated in early Alzheimer's disease. Neurology 1988;38:1228-1232.
36. Nordin S, Monsch AU, Murphy C. Unawareness of smell loss in normal aging and Alzheimer's disease: discrepancy between self-reported and diagnosed smell sensitivity. J Gerontol 1995; 50:P187-P192.
37. Murphy C, Jinich S. Olfactory dysfunction in Down's syndrome. Neurobiol Aging 1995;17:631-637.
38. Rezek DL. Olfactory deficits as a neurologic sign in dementia of the Alzheimer type. Arch Neurol 1987;44:1030-1032.