Atomic structure of a Na+- and K+-conducting channel

Nature

Volumn 440, Issue 7083, 2006, Pages 570-574

  Shi, Ning ^a   Ye, Sheng ^a   Alam, Amer ^a   Chen, Liping ^a   Jiang, Youxing ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CALCIUM COMPOUNDS; CRYSTAL STRUCTURE; HEAT CONDUCTION; HOMOPOLYMERIZATION; POTASSIUM; SODIUM; STRUCTURAL ANALYSIS;

ATOMIC STRUCTURES; CATION CHANNELS; CHANNEL SELECTIVITY; CONDUCTING CHANNELS;

CRYSTAL ATOMIC STRUCTURE;

CYCLIC NUCLEOTIDE; POTASSIUM CHANNEL; RUBIDIUM 86; SODIUM CHANNEL;

SCIENCE AND TECHNOLOGY;

ARTICLE; BACILLUS CEREUS; BINDING SITE; CHANNEL GATING; CRYSTAL STRUCTURE; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SODIUM CONDUCTANCE; VESTIBULE;

BACILLUS CEREUS; BACTERIA (MICROORGANISMS);

EID: 33645318420     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04508     Document Type: Article

References (27)

1. + channel-Fab complex at 2.0 Å resolution. Nature 414, 43-48 (2001).
2. + conduction and selectivity. Science 280, 69-77 (1998).
3. + channels. Science 258, 1152-1155 (1992).
4. + channel signature sequence. Biophys. J. 66, 1061-1067 (1994).
5. Yau, K. W. & Baylor, D. A. Cyclic GMP-activated conductance of retinal photoreceptor cells. Annu. Rev. Neurosci. 12, 289-327 (1989).
6. Kaupp, U. B. & Seifert, R. Cyclic nucleotide-gated ion channels. Physiol. Rev. 82, 769-824 (2002).
7. Matulef, K. & Zagotta, W. N. Cyclic nucleotide-gated ion channels. Annu. Rev. Cell Dev. Biol. 19, 23-44 (2003).
8. Zagotta, W. N. & Siegelbaum, S. A. Structure and function of cyclic nucleotide-gated channels. Annu. Rev. Neurosci. 19, 235-263 (1996).
9. + selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates. J. Mol. Biol. 333, 965-975 (2003).
10. Haynes, L. W., Kay, A. R. & Yau, K. W. Single cyclic GMP-activated channel activity in excised patches of rod outer segment membrane. Nature 321, 66-70 (1986).
11. Stern, J. H., Knutsson, H. & MacLeish, P. R. Divalent cations directly affect the conductance of excised patches of rod photoreceptor membrane. Science 236, 1674-1678 (1987).
12. Colamartino, G., Menini, A. & Torre, V. Blockage and permeation of divalent cations through the cyclic GMP-activated channel from tiger salamander retinal rods. J. Physiol. (Lond.) 440, 189-206 (1991).
13. Zimmerman, A. L. & Baylor, D. A. Cation interactions within the cyclic GMP-activated channel of retinal rods from the tiger salamander. J. Physiol. (Lond.) 449, 759-783 (1992).
14. Frings, S., Seifert, R., Godde, M. & Kaupp, U. B. Profoundly different calcium permeation and blockage determine the specific function of distinct cyclic nucleotide-gated channels. Neuron 15, 169-179 (1995).
15. Zufall, F., Firestein, S. & Shepherd, G. M. Cyclic nucleotide-gated ion channels and sensory transduction in olfactory receptor neurons. Annu. Rev. Biophys. Biomol. Struct. 23, 577-607 (1994).
16. Armstrong, C. M. & Taylor, S. R. Interaction of barium ions with potassium channels in squid giant axons. Biophys. J. 30, 473-488 (1980).
17. Armstrong, C. M., Swenson, R. P. Jr & Taylor, S. R. Block of squid axon K channels by internally and externally applied barium ions. J. Gen. Physiol. 80, 663-682 (1982).
18. Jiang, Y. & MacKinnon, R. The barium site in a potassium channel by X-ray crystallography. J. Gen. Physiol. 115, 269-272 (2000).
19. + channel. J. Gen. Physiol. 111, 741-749 (1998).
20. Noskov, S. Y., Berneche, S. & Roux, B. Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands. Nature 431, 830-834 (2004).
21. Haynes, L. & Yau, K. W. Cyclic GMP-sensitive conductance in outer segment membrane of catfish cones. Nature 317, 61-64 (1985).
22. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997).
23. Schneider, T. R. & Sheldrick, G. M. Substructure solution with SHELXD. Acta Crystallogr. D Biol. Crystallogr. 58, 1772-1779 (2002).
24. Collaborative Computational Project, Number 4, The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50, 760-763 (1994).
25. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110-119 (1991).
26. Brunger, A. T. et al. Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 54, 905-921 (1998).
27. + channels: functional asymmetries and sidedness of proton activation. J. Gen. Physiol. 114, 551-560 (1999).