Mutagenesis within helix 6 of the human β1-adrenergic receptor identifies lysine324 as a residue involved in imparting the high-affinity binding state of agonists

Molecular Pharmacology

Volumn 70, Issue 3, 2006, Pages 838-850

  Zeitoun, Omeima ^a   Delos Santos, Noel M ^a   Gardner, Lidia A ^a   White, Stephen W ^b   Bahouth, Suleiman W ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ADRENALIN; ALANINE; ARGININE; ASPARTIC ACID; BETA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; DOBUTAMINE; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; ISOETARINE; ISOPRENALINE; LYSINE; MUTANT PROTEIN; NORADRENALIN; PARTIAL AGONIST; TERBUTALINE; TYROSINE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE;

ADENYLATE CYCLASE; ADRENERGIC AGONISTS; AMINO ACID SEQUENCE; CELLS, CULTURED; ENZYME ACTIVATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; ISOPROTERENOL; LYSINE; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; RECEPTORS, ADRENERGIC, BETA-1; REPRODUCIBILITY OF RESULTS;

EID: 33747597571     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.025346     Document Type: Article

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