Interdomain interactions regulate the activation of the heme-regulated eIF2α kinase

Biochimica et Biophysica Acta - General Subjects

Volumn 1725, Issue 2, 2005, Pages 174-181

  Yun, Bo Geon ^a   Matts, Jessica A B ^a   Matts, Robert L ^a  

^a OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

Carbon monoxide; Heme; Heme binding domain; Heme regulated eIF2 kinase; Interdomain interaction; Nitric oxide

Indexed keywords

AMINO ACID; CARBON MONOXIDE; HEME; HEMIN; MUTANT PROTEIN; NITRIC OXIDE; PROTEIN KINASE R;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CARBON MONOXIDE; CELLS, CULTURED; EIF-2 KINASE; ENZYME ACTIVATION; HEME; MUTAGENESIS, SITE-DIRECTED; NITRIC OXIDE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RABBITS; RECOMBINANT PROTEINS; RETICULOCYTES; STRUCTURE-ACTIVITY RELATIONSHIP;

EUKARYOTA;

EID: 24344444080     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2005.07.011     Document Type: Article

References (24)

1. T.E. Dever Translation initiation: adept at adapting Trends Biochem. Sci. 24 1999 398 403
2. J.J. Chen, and I.M. London Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase Trends Biochem. Sci. 20 1995 105 108
3. S. Uma, S.D. Hartson, J.J. Chen, and R.L. Matts Hsp90 is obligatory for the heme-regulated eIF-2alpha kinase to acquire and maintain an activable conformation J. Biol. Chem. 272 1997 11648 11656
4. S. Uma, V. Thulasiraman, and R.L. Matts Dual role for Hsc70 in the biogenesis and regulation of the heme-regulated kinase of the α subunit of eukaryotic translation initiation factor 2 Mol. Cell. Biol. 19 1999 5861 5871
5. cdc37 function during the biogenesis of the active conformation of the heme-regulated eIF2α kinase J. Biol. Chem. 276 2001 206 214
6. J. Shao, S.D. Hartson, and R.L. Matts Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase Biochemistry 41 2002 6770 6779
7. L. Lu, A.P. Han, and J.J. Chen Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses Mol. Cell. Biol. 21 2001 7971 7980
8. B.N. Bauer, M. Rafie-Kolpin, L. Lu, A. Han, and J.J. Chen Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase Biochemistry 40 2001 11543 11551
9. R. Fagard, and I.M. London Relationship between phosphorylation and activity of heme-regulated eukaryotic initiation factor 2 alpha kinase Proc. Natl. Acad. Sci. U. S. A. 78 1981 866 870
10. R. Mendez, A. Moreno, and C. de Haro Regulation of heme-controlled eukaryotic polypeptide chain initiation factor 2 alpha-subunit kinase of reticulocyte lysates J. Biol. Chem. 267 1992 11500 11507
11. M. Rafie-Kolpin, P.J. Chefalo, Z. Hussain, J. Hahn, S. Uma, R.L. Matts, and J.J. Chen Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion J. Biol. Chem. 275 2000 5171 5178
12. S. Uma, R.L. Matts, Y. Guo, S. White, and J.J. Chen The N-terminal region of the heme-regulated eIF2alpha kinase is an autonomous heme binding domain Eur. J. Biochem. 267 2000 498 506
13. P.J. Chefalo, J. Oh, M. Rafie-Kolpin, B. Kan, and J.J. Chen Heme-regulated eIF-2alpha kinase purifies as a hemoprotein Eur. J. Biochem. 258 1998 820 830
14. S. Uma, B.G. Yun, and R.L. Matts The heme-regulated eukaryotic initiation factor 2alpha kinase. A potential regulatory target for control of protein synthesis by diffusible gases J. Biol. Chem. 276 2001 14875 14883
15. H. Ishikawa, B.G. Yun, S. Takahashi, H. Hori, R.L. Matts, K. Ishimori, and I. Morishima NO-induced activation mechanism of the heme-regulated eIF2alpha kinase J. Am. Chem. Soc. 124 2002 13696 13697
16. G. Deinum, J.R. Stone, G.T. Babcock, and M.A. Marletta Binding of nitric oxide and carbon monoxide to soluble guanylate cyclase as observed with resonance Raman spectroscopy Biochemistry 35 1996 1540 1547
17. T. Inuzuka, B.G. Yun, H. Ishikawa, S. Takahashi, H. Hori, R.L. Matts, K. Ishimori, and I. Morishima Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase J. Biol. Chem. 279 2004 6778 6782
18. J. Igarashi, A. Sato, T. Kitagawa, T. Yoshimura, S. Yamauchi, I. Sagami, and T. Shimizu Activation of heme-regulated eukaryotic initiation factor 2alpha kinase by nitric oxide is induced by the formation of a five-coordinate NO-heme complex: optical absorption, electron spin resonance, and resonance Raman spectral studies J. Biol. Chem. 279 2004 15752 15762
19. M. Rafie-Kolpin, A.P. Han, and J.J. Chen Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI Biochemistry 42 2003 6536 6544
20. J.M. Yang, I.M. London, and J.J. Chen Effects of hemin and porphyrin compounds on intersubunit disulfide formation of heme-regulated eIF-2 alpha kinase and the regulation of protein synthesis in reticulocyte lysates J. Biol. Chem. 267 1992 20519 20524
21. J.J. Chen, J.M. Yang, R. Petryshyn, N. Kosower, and I.M. London Disulfide bond formation in the regulation of eIF-2 alpha kinase by heme J. Biol. Chem. 264 1989 9559 9564
22. B.T. Scroggins, T. Prince, J. Shao, S. Uma, W. Huang, Y. Guo, B.G. Yun, K. Hedman, R.L. Matts, and S.D. Hartson High affinity binding of Hsp90 is triggered by multiple discrete segments of its kinase clients Biochemistry 42 2003 12550 12561
23. B.G. Yun, W. Huang, N. Leach, S.D. Hartson, and R.L. Matts Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions Biochemistry 43 2004 8217 8229
24. S. Zhu, A.Y. Sobolev, and R.C. Wek Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2 J. Biol. Chem. 271 1996 24989 24994