Personality, dopamine receptor D4 exon III polymorphisms, and academic achievement in medical students

Neuropsychobiology

Volumn 53, Issue 4, 2006, Pages 203-209

  Ham, Byung Joo ^a   Lee, Young Mee ^b   Kim, Meyoung Kon ^b   Lee, Juneyoung ^b   Ahn, Duck Sun ^b   Choi, Myoung Jin ^b   In, Kyoon Lyoo ^c   Choi, Ihn Geun ^a   Lee, Min Soo ^b  

^a Hallym University Medical Center   (South Korea)

^b Korea University College of Medicine   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

Author keywords

Academic achievement; Dopamine D4 receptor; Personality traits

Indexed keywords

DOPAMINE 4 RECEPTOR; GENOMIC DNA;

ACADEMIC ACHIEVEMENT; ADULT; ANXIETY DISORDER; ARTICLE; BECK DEPRESSION INVENTORY; CONTROLLED STUDY; DEPRESSION; DNA POLYMORPHISM; EXON; FEMALE; GENE FREQUENCY; HEREDITY; HUMAN; HUMAN CELL; MALE; MEDICAL STUDENT; MULTIPLE REGRESSION; NORMAL HUMAN; PERSONALITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUESTIONNAIRE; SOUTH KOREA; STATE TRAIT ANXIETY INVENTORY; TEMPERAMENT; VARIABLE NUMBER OF TANDEM REPEAT;

ADULT; CHI-SQUARE DISTRIBUTION; EDUCATIONAL STATUS; EXONS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MINISATELLITE REPEATS; PERSONALITY; PERSONALITY INVENTORY; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D4; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEX FACTORS; STUDENTS, MEDICAL;

EID: 33747423331     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094729     Document Type: Article

References (37)

1. Costa PT, McCrae RR: Neo-PI-R Professional Manual. Odessa, Psychological Assessment Resources, 1992.
2. McCrae RR: Creativity, divergent thinking, and openness to experience. J Pers Soc Psychol 1987;52:1258-1265.
3. Lievens F, Coetsier P, De Fruyt F, De Maeseneer J: Medical students' personality characteristics and academic performance: a five-factor model perspective. Med Educ 2002;36:1050-1056.
4. McKenzie JM: Neuroticism and academic achievement: The Furneaux factor. Personality and Individual Differences. Personality and Individual Differences, 1989;10:509-515.
5. Cloninger CR, Svrakic DM, Przybeck TR: A psychobiological model of temperament and character. Arch Gen Psychiatry 1993;50:975-990.
6. Svrakic DM, Draganic S, Hill K, Bayon C, Przybeck TR, Cloninger CR: Temperament, character, and personality disorders: etiologic, diagnostic, treatment issues. Acta Psychiatr Scand 2002;106:189-195.
7. Hoschl C, Kozeny J: Predicting academic performance of medical students: the first three years. Am J Psychiatry 1997;154(suppl 6):87-92.
8. Stallings MC, Hewitt JK, Cloninger CR, Heath AC, Eaves LJ: Genetic and environmental structure of the Tridimensional Personality Questionnaire: three or four temperament dimensions? J Pers Soc Psychol 1996;70:127-140.
9. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH: Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat Genet 1996;12:81-84.
10. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D, Bennett ER, Nemanov L, Katz M, Belmaker RH: Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nat Genet 1996;12:78-80.
11. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL: Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-1531.
12. Sung SM, Kim JH, Yang E, Abrams KY, Lyoo IK: Reliability and validity of the Korean version of the Temperament and Character Inventory. Compr Psychiatry 2002;43:235-243.
13. Hong MH, Yum TH, Shin YW, Kim KH, Yoon DJ, Chung KJ: A standardization study of Beck Depression Inventory in Korea. J Korean Neuropsychiatr Assoc 1986;25:487-500.
14. Hahn DW, Lee CH, Chon KK: Korean Adaptaion of Spielberger's STAI (K-STAI). Korean J Health Psychol 1996;1:1-14.
15. Lichter JB, Barr CL, Kennedy JL, Van Tol HH, Kidd KK, Livak KJ: A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet 1993;2:767-773.
16. Lee HJ, Lee HS, Kim YK, Kim SH, Kim L, Lee MS, Joe SH, Jung IK, Suh KY, Kim S: Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population. Am J Med Genet B Neuropsychiatr Genet 2003;118:76-80.
17. Van Tol HH, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O: Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 1991;350:610-614.
18. Asghari V, Sanyal S, Buchwaldt S, Paterson A, Jovanovic V, Van Tol HH: Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 1995;65:1157-1165.
19. Wang E, Ding YC, Flodman P, Kidd JR, Kidd KK, Grady DL, Ryder OA, Spence MA, Swanson JM, Moyzis RK: The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am J Hum Genet 2004;74:931-944.
20. De Fruyt F, Mervielde I: Personality and interests as predictors of educational streaming and achievement. Eur J Pers 1996;10:405-425.
21. Musgrave-Marquart D, Bromley SP, Dalley MB: Personality, academic attribution, and substance use as predictors of academic achievement in college students. J Soc Behav Pers 1997;12:501-511.
22. Dollinger SJ, Orf LA: Personality and performance in personality? Conscientiousness and openness. J Res Pers 1991;25:276-284.
23. McCown W, Johnson J: Personality and chronic procrastination by university students during an academic examination period. Pers Individ Dif 1991;12:413-415.
24. Ferguson E, James D, Madeley L: Factors associated with success in medical school: systematic review of the literature. BMJ 2002;324:952-957.
25. Heiligenstein E, Guenther G, Hsu K, Herman K: Depression and academic impairment in college students. J Am Coll Health 1996;45:59-64.
26. Andrews B, Wilding JM: The relation of depression and anxiety to life-stress and achievement in students. Br J Psychol 2004;95:509-521.
27. Ham BJ, Choi MJ, Lee HJ, Kang RH, Lee MS: Reward dependence is related to norepinephrine transporter T-182C gene polymorphism in a Korean population. Psychiatr Genet 2005;15:145-147.
28. Mitsuyasu H, Hirata N, Sakai Y, Shibata H, Takeda Y, Ninomiya H, Kawasaki H, Tashiro N, Fukumaki Y: Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits. J Hum Genet 2001;46:26-31.
29. Ebstein RP, Segman R, Benjamin J, Osher Y, Nemanov L, Belmaker RH: 5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms. Am J Med Genet 1997;74:65-72.
30. Ono Y, Manki H, Yoshimura K, Muramatsu T, Mizushima H, Higuchi S, Yagi G, Kanba S, Asai M: Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects. Am J Med Genet 1997;74:501-503.
31. Noble EP, Ozkaragoz TZ, Ritchie TL, Zhang X, Belin TR, Sparkes RS: D2 and D4 dopamine receptor polymorphisms and personality. Am J Med Genet 1998;81:257-267.
32. Malhotra AK, Virkkunen M, Rooney W, Eggert M, Linnoila M, Goldman D: The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking. Mol Psychiatry 1996;1:388-391.
33. Sullivan PF, Fifield WJ, Kennedy MA, Mulder RT, Sellman JD, Joyce PR: No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples. Am J Psychiatry 1998;155:98-101.
34. Mitsuyasu H, Ozawa H, Takeda Y, Fukumaki Y: Novel polymorphisms in the upstream region of the human dopamine D4 receptor (DRD4) gene. J Hum Genet 1999;44:416-418.
35. Okuyama Y, Ishiguro H, Nankai M, Shibuya H, Watanabe A, Arinami T: Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait. Mol Psychiatry 2000;5:64-69.
36. Ekelund J, Lichtermann D, Jarvelin MR, Peltonen L: Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample. Am J Psychiatry 1999;156:1453-1455.
37. Becker K, Laucht M, El-Faddagh M, Schmidt MH: The dopamine D4 receptor gene exon III polymorphism is associated with novelty seeking in 15-year-old males from a high-risk community sample. J Neural Transm 2005;112:847-858.