Synthesis and biological evaluation of benzamides and benzamidines: Structural requirement of a pyrimidine ring for inhibition of EGFR tyrosine kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 9, 2004, Pages 2299-2302

  Asano, Toru ^a   Yoshikawa, Tomohiro ^b   Nakamura, Hiroyuki ^b   Uehara, Yoshimasa ^c   Yamamoto, Yoshinori ^b  

^a GAKUSHUIN UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Benzamidines; EGFR; Inhibitor; Tyrosine kinase

Indexed keywords

BENZAMIDE DERIVATIVE; BENZAMIDINE DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE;

ARTICLE; AUTOPHOSPHORYLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50;

BENZAMIDES; BENZAMIDINES; CELL LINE, TUMOR; HUMANS; MOLECULAR STRUCTURE; RECEPTOR, EPIDERMAL GROWTH FACTOR;

STAPHYLOCOCCUS PHAGE 3A;

EID: 1842851783     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.02.001     Document Type: Article

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