The molecular basis for the selection of captopril cis and trans conformations by angiotensin I converting enzyme

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 19, 2006, Pages 5084-5087

  Tzakos, Andreas G ^a   Naqvi, Nawazish ^b   Comporozos, Konstantinos ^c   Pierattelli, Roberta ^d   Theodorou, Vassiliki ^c   Husain, Ahsan ^b   Gerothanassis, Ioannis P ^c  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF IOANNINA   (Greece)

^d UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Angiotensin converting enzyme; Captopril; Isomerization; Mutagenesis; NMR

Indexed keywords

CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

ARTICLE; BINDING AFFINITY; CALCULATION; DRUG CONFORMATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; EVIDENCE BASED MEDICINE; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE; PH; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CAPTOPRIL; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTAGENESIS; PEPTIDYL-DIPEPTIDASE A; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33747329351     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.034     Document Type: Article

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