Molecular basis of exopeptidase activity in the C-terminal domain of human angiotensin I-converting enzyme: Insights into the origins of its exopeptidase activity

Journal of Biological Chemistry

Volumn 280, Issue 8, 2005, Pages 6669-6675

  Naqvi, Nawazish ^a,b   Liu, Ke ^a,b   Graham, Robert M ^a,c   Husain, Ahsan ^a,b  

^a VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CARBOXYLATION; CATALYST ACTIVITY; ELECTROSTATICS; MUTAGENESIS; SUBSTRATES; X RAYS;

ANGIOTENSIN I-CONVERTING ENZYME (ACE); BIOLOGICAL CONTROL; EXOPEPTIDASE ACTIVITY;

ENZYME KINETICS;

ANGIOTENSIN I; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE; EXOPEPTIDASE; LYSINE; METALLOPROTEINASE; PROTEINASE; SUBSTANCE P; TYROSINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CHEMICAL BOND; CONTROLLED STUDY; ELECTRICITY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; EVOLUTION; HUMAN; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING; TANDEM REPEAT;

ANGIOTENSIN I; BRADYKININ; COMPUTER SIMULATION; ELECTROSTATICS; EVOLUTION, MOLECULAR; EXOPEPTIDASES; HUMANS; KINETICS; MUTATION; PEPTIDYL-DIPEPTIDASE A; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SUBSTANCE P; SUBSTRATE SPECIFICITY;

EID: 14844304657     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412638200     Document Type: Article

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