Advances in molecular genetics of Candida albicans and Candida glabrata

Medical Mycology, Supplement

Volumn 36, Issue 1, 1998, Pages 230-237

  Brown, A J P ^a   Cormack, B P ^b   Gow, N A R ^a   Kvaal, C ^c   Soll, D R ^c   Srikantha, T ^c  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

C type lectin; Candida albicans; Candida glabrata; Disruption mutants; Phase specific genes; Two component phospho relay regulators

Indexed keywords

CANDIDA ALBICANS; CANDIDA GLABRATA; CONFERENCE PAPER; FUNGAL GENETICS; FUNGUS MUTATION; GENE OVEREXPRESSION; MOLECULAR GENETICS; NONHUMAN; PROMOTER REGION;

CANDIDA; CANDIDA ALBICANS; CANDIDIASIS; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; HUMANS; LECTINS; MUTATION; VIRULENCE;

EID: 33747111268     PISSN: 09668454     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (51)

1. Fonzi WA, Irwin MY. Isogenic strain construction and gene mapping in Candida albicans. Genetics 1993; 134: 717-28.
2. Brown DH, Slobodkin IV, Kumamoto CA. Stable transformation and regulated expression of an inducible reporter construct in Candida albicans using restriction enzyme mediated integration. Mol Gen Genet 1996; 251: 75-80.
3. Jiang W, Gerhold D, Kmiec EB, Hausewr M, Becker JM, Koltin Y. The topoisomerase I gene of Candida albicans. Microbiology 1997; 143: 337-86.
4. Kvaal C, Srikantha T, Soll DR. Mis-expression of the white phase- specific gene WH11 in the opaque phase of Candida albicans affects switching and virulence. Infect Immun 1997; 65: 4468-75.
5. Bailey DA, Feldmann PJ, Bovey M, Gow NAR, Brown NAR. The Candida albicans HYRI gene, which is activated in response to hyphal development, belongs to a gene family encoding cell wall proteins. J Bacteriol 1996; 178: 5353-60.
6. Leberer E, Harcus D, Broadbent ID, Clark KL, Dignard D. Wiegelbauer K, Schonfield W, Gow NAR, Brown APJ, Thomas DY. Signal transduction through homologs of the ste20p and ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc Natl Acad Sci USA 1996; 93: 13217-22.
7. Srikantha T, Klapach A, Lorenz WW, Tsai LK, Laughlin LA, Gorman JA, Soil DR. The sea pansy Renilla reniformis luciferase serves as a sensitive bioluminescent reporter for differential gene expression in Candida albicans. J Bacteriol 1996; 178: 121-9.
8. Cormack BP, Bertram G, Egerton M, Gow NAR, Falkow S, Brown APJ. Yeast enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans Microbiology 1997; 142: 303-11.
9. Alex LA, Borkovich KA, Simon MI. Hyphal development in Neurospora crassa: Involvement of a two-component histidine kinase. Microbiology 1996; 93: 3416-21.
10. Sanglard D, Hube B, Monod M, Odds FC, Gow NAR. Deletion of the secretory aspartyl proteinase genes SAP4, SAP5 and SAP6 causes attenuated virulence in Candida albicans. Infect Immun 1997; 65: 3539-46.
11. Hube B, Monod M, Scholfield DA, Brown AJP, Gow NAR. Transcriptional regulation of six members of the gene family encoding aspartyl proteinases in Candida albicans. Mol Microbial 1994; 14: 87-99.
12. Hube B, Sanglard D, Odds FC, Hess D. Monod M, Schafer W, Brown AJP, Gow NAR. Gene disruption of each of the secretory aspartyl proteinase genes SAP1, SAP2 and SAP3 in Candida albicans attenuates virulence. Infect Immun 1997; 65: 3529-38.
13. Westwater C, Buurman ET, Cho T, Gooday GW, Brown APJ, Gow NAR Molecular analysis of two Candida albicans mannosyl transferase (MNT) genes. In: Suzuki S, Suzuki M, eds, Fungal Pathogens and Biodefence Mechanisms, pp. 227-32. Saikon Publishing Co. Ltd., Japan 1997.
14. Bulawa CE, Miller DW, Henry LK, Becker JM. Attenuated virulence of chitin-deficient mutants of Candida albicans. Proc Natl Acad Sci USA 1995; 92: 10570-4.
15. Gow NAR, Robbins PW, Lester JW, Brown AJP, Fonzi WA, Chapman T, Kinsman OK. A hyphal-specific chitin synthase gene (CHS2) is not essential for growth, dimorphism or virulence of Candida albicans. Proc Natl Acad Sci USA 1994; 91: 6216-20.
16. Γ gene. Antimicrob Agents Chemother 1995; 39: 422-6.
17. Bertram G, Swoboda RK, Goody GW, Gow NAR, Brown APJ. Structure and regulation of the Candida albicans ADH1 gene encoding an immunogenic alcohol dehydrogenase. Yeast 1996; 12: 115-27.
18. Santos MA, Tuite MF. The CUG codon is decoded in vivo as serine and leucine in Candida albicans. Nucl Acids Res 1995; 23: 1481-6.
19. Lockhart S, Fritch JJ, Meier AS, Schr, oppel K, Srikantha T, Galask R, Soll DR. Colonizing populations of Candida albicans are clonal in origin but undergo microevolution through Cl fragment reorganization as demonstrated by DNA fingerprinting and Cl sequencing. J Clin Microbiol 1995; 33: 1501-9.
20. Lockhart S, Reed B, Soll DR. Most frequent scenario for recurrent Candida vaginitis is strain maintenance with 'substrain shuffling': demonstration by sequential DNA fingerprinting with probes Ca3, C1 and CARE2. J Clin Microbiol; 34: 767-77 1996.
21. Schr, oppel K, Rotman M, Galask R, Mac K, Soll DR. The evolution and replacement of C. albicans strains during recurrent vaginitis demonstrated by DNA fingerprinting. J Clin Microbiol 1994; 32: 2646-54.
22. Soll DR. Switching and its possible role in Candida pathogenesis. In: Bennett JE, Hay RJ, Peterson PK, eds. New Strategies in Fungal Disease, pp. 156-172. Churchill Livingstone, Edinburgh, 1992.
23. Berg DE, Howe MM, Mobile DNA. American Society for Microbiology. Washington, DC 1991.
24. Soll DR. High frequency switching in Candida albicans. Clin Microbiol Rev 1992; 5: 183-203.
25. Soll DR. The emerging molecular biology of switching in Candida albicans. ASM News 1997; 62: 415-20.
26. Soll DR. Gene regulation during high frequency switching in Candida albicans. Microbiology 1997; 143: 279-88.
27. Morrow B, Snkantha T, Soil DR. Transcription of the gene for a pepsinogen. PEP1, is regulated by white-opaque switching in Candida albicans. Mol Cell Biol 1992; 12: 2997-3005.
28. Morrow B, Srikantha T, Anderson F, Soll DR. Coordinate regulation of two opaque-specific genes during white-opaque switching in Candida albicans. Infect Immun 1993; 61: 1823-8.
29. White TC, Miyasaki SH, Agabian N. Three distinct secreted aspartyl proteinases in Candida albicans. J Bacreriol 1993; 175: 6126-33.
30. Srikantha T, Soll DR. A white-specific gene in the white-opaque switching system of Candida albicans. Gene 1993; 131: 53-60.
31. Srikantha T, Chandrasekhar A, Soll DR. Functional analysis of the promoter of the phase-specific WH11 gene of Candida albicans. Mol Cell Biol 1995; 15: 1797-805.
32. Srikantha T, Tsai L, Soll DR. The WH11 gene of Candida albicans is regulated in two distinct development programs through the same transcription activation domains. J Bacteriol 1997; 179: 3837-44.
33. Varela JC, Prackelt UM, Meacock PA, Planto RJ, Mager WH. The Saccharomyces cerevisiae HSP12 gene is activated by the high osmolarity glycerol pathway and negatively regulated by protein kinase A. Mol Cell Biol 1995; 15: 6232-45.
34. Schr, oppel K, Srikantha T, DeCock M, Wessels D, Lockhart S, Soll DR. Cytoplasmic localization of the white phase-specific WH11 gene product of Candida albicans. Microbiology 1996; 142: 2245-54.
35. Soll DR, Srikantha T, Chandrasekhar A, Morrow B, Schr, oppel K, Lockhart S. Gene regulation in the White-Opaque Transition of Candida albicans. Can J Bot 1995; 73 (Suppl. 1): S1049-S1057.
36. Anderson JM, Soll DR. The unique phenotype of opaque cells in the 'white-opaque transition' in Candida albicans. J Bacteriol 1987; 169: 5579-88.
37. Parkinson JS, Kofoid EC. Communication modules in bacterial signaling proteins [Review]. Annu Rev Genet 1992; 26: 71-112.
38. Saier MH. Bacterial protein kinases that recognize tertiary rather than primary structure? [Review]. Res Microbiol 1994; 145: 349-491.
39. Hrabak EM, Willis DK. The lemA gene required for pathogenicity of Pseudomonas syringae pv, syringae on beans is a member of a family of two- component regulators. J Bacteriol 1992; 174: 3011-20.
40. Nagasawa S, Tokishita S, Aiba H, Mizuno T. A novel sensor-regulator protein that belongs to the homologous family of signal-transduction proteins involved in adaptive responses in Escherichia coli. Mol Microbiol 1992; 6: 799-807.
41. Ota IM, Varshavsky A. A yeast protein similar to bacterial two-component regulators. Science 1993; 262: 566-9.
42. Maeda T, Wurgler-Murphy MS, Saito H. A two-component system that regulates an osmosensing MAP kinase. Nature 1994; 369: 242-5.
43. Maeda T, Takekawa M, Saito H Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science 1995; 269: 554-8.
44. Posas F, Wurgler-Murphy N, MaedaT, Witten EA, Thai TC, Saito H. Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the ALN1-YPD1-SSK1 'two-component' osmosensor. Cell 1996; 86: 865-875.
45. Yu G, Deschenes RJ, Fassler JS. The essential transcription factor Mcm1, is a downstream target of Sln1, a yeast 'two-component' regulator. J Biol Chem 1995; 270: 8739-43.
46. Kuo C, Grayhack E. A library of yeast genomic MCM1 binding sites contains genes involved in cell cycle control, cell wall and membrane structure, and metabolism. Mol Cell Biol 1994; 14: 348-59.
47. Passmore SG, Maine T, Eible RChr, ist C, Tye BK. Saccharomyces cerevisiae protein involved in plasmid maintenance is necessary for mating of MAT alpha cells J Mol Biol 1988; 204: 593-606.
48. Treisman T, Ammerer G. The SRF and MCM1 transcription factors [Review]. Curr Opin Genet Dev 1992; 2: 718-29.
49. Nagahashi S, Mio T, Omo N, Yamada-Okabe T, Arisawn M, Bussey H, Yamada-Okabe H. Isolation of CaSLN1 and CaNIK1, the genes for osmosizing histidine kinase homologues, from the pathogenic fungus Candida albicans. Microbiology 1998; 144: 425-32.
50. Hensel M, JE.Shea C, Gleeson MD, Jones E, Dalton, DW, Holden. Simultaneous identification of bacterial virulence genes by negative selection. Science 1995; 269: 400-3.
51. Yu L, Lee KK, Sheth HB, Lane-Bell P, Srivastavva G, Hindsgaul O, Paranchych W, Hodges RS, Irvin RT. Fimbria-mediated adherence of Candida albicans to glycosphingolipid receptors on human buccal epithelial cells. Infect Immun 1994; 62: 2843-8.