Thi20, a remarkable enzyme from Saccharomyces cerevisiae with dual thiamin biosynthetic and degradation activities

Bioorganic Chemistry

Volumn 33, Issue 4, 2005, Pages 338-344

  Haas, Amy L ^a   Laun, Nathan P ^a   Begley, Tadhg P ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

4 Amino 2 methyl 5 hydroxymethylpyrimidine kinase; Thiamin; Thiamin biosynthesis; Thiamin degradation; Thiamin metabolism; Thiaminase II

Indexed keywords

ADENOSINE TRIPHOSPHATE; FUNGAL ENZYME; HYBRID PROTEIN; PYRIMIDINE DERIVATIVE; THIAMINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BACILLUS SUBTILIS; CARBOXY TERMINAL SEQUENCE; ENZYME DEGRADATION; ENZYME METABOLISM; ENZYME SYNTHESIS; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; STRUCTURAL HOMOLOGY;

AMINO ACID SEQUENCE; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROLASES; MOLECULAR SEQUENCE DATA; PHOSPHOTRANSFERASES; PYRIMIDINES; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; THIAMINE;

BACILLUS SUBTILIS; SACCHAROMYCES CEREVISIAE;

EID: 21844450588     PISSN: 00452068     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bioorg.2005.04.001     Document Type: Article

References (15)

1. B. Llorente, C. Fairhead, and B. Dujon Mol. Microbiol. 32 1999 1140 1152
2. J.H. Park, K. Burns, C. Kinsland, and T. Begley J. Bacteriol. 186 2004 1571 1573
3. T.P. Begley Nat. Prod. Rep. 3 1996 177 185
4. E. Settembre, T.P. Begley, and S.E. Ealick Opin. Struct. Biol. 13 2003 739 747
5. A.V. Toms, A.L. Haas, J.H. Park, T.P. Begley, and S.E. Ealick Biochemistry 44 2005 2319 2329
6. C.A. Costello, N.L. Kelleher, M. Abe, F.W. McLafferty, and T.P. Begley J. Biol. Chem. 271 1996 3445 3452
7. N. Campbasso, C. Costello, C. Kinsland, and T.P. Begley Biochemistry 37 1998 15891 15989
8. G.E. Lienhard Biochemistry 9 1970 3011 3020
9. R. Nicewonger, C.A. Costello, and T.P. Begley J. Org. Chem. 61 1996 4172 4174
10. A. Fujita J. Vitamin 18 1972 67 72
11. K. Murata Ann. N Y Acad. Sci. 378 1982 146 156
12. K. Murata, in: Review of Japanese Literature on Beriberi and Thiamine, Kyoto, 1965, pp. 220-254.
13. A. Fujita Adv. Enzymol. 19 1954 389 421
14. W. Charles Evans Vitam. Horm. 33 1975 467 504
15. Y. Kimura, and A. Iwashima Experientia 43 1987 888 890