The Biosynthesis of the Thiazole Phosphate Moiety of Thiamin (Vitamin B1): The Early Steps Catalyzed by Thiazole Synthase

Journal of the American Chemical Society

Volumn 126, Issue 10, 2004, Pages 3091-3096

  Dorrestein, Pieter C ^a   Zhai, Huili ^a   Taylor, Sean V ^a   McLafferty, Fred W ^a   Begley, Tadhg P ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; ENZYMES; KETONES; MASS SPECTROMETRY;

IMINE INTERMEDIATES; NUCLEOPHILIC ADDITIONS;

VITAMINS;

1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE; CARBONYL DERIVATIVE; CARRIER PROTEIN; COCARBOXYLASE; PHOSPHATE; THIAMINE; THIAZOLE DERIVATIVE; THIAZOLE SYNTHASE; UNCLASSIFIED DRUG;

AMADORI REARRANGEMENT; ARTICLE; BACILLUS SUBTILIS; BIOSYNTHESIS; CHEMICAL ANALYSIS; COMPLEX FORMATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; MASS SPECTROMETRY; REDUCTION;

AMINO ACID SEQUENCE; BACILLUS SUBTILIS; CATALYSIS; DEUTERIUM EXCHANGE MEASUREMENT; IMINES; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXYGEN; PENTOSEPHOSPHATES; PHOSPHORIC ACID ESTERS; THIAMINE; THIAZOLES; TRANSFERASES;

EID: 1642407640     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja039616p     Document Type: Article

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