Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 Å resolution

Structure

Volumn 10, Issue 2, 2002, Pages 225-235

  Cheng, Gong ^a   Bennett, Eric M ^a   Begley, Tadhg P ^a   Ealick, Steven E ^a  

^a Cornell University ^*  (United States)

Author keywords

Catalytic mechanism; Kinase; Phosphorylation; Ribokinase family; Thiamin biosynthesis; ThiD

Indexed keywords

4 AMINO 5 HYDROXYMETHYL 2 METHYLPYRIMIDINE PHOSPHATE KINASE; ADENOSINE TRIPHOSPHATE; BACTERIAL ENZYME; DIMER; ENZYME; PHOSPHATE; RIBOKINASE; THIAMINE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; COMPARATIVE STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; MOLECULAR EVOLUTION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN FAMILY; SALMONELLA TYPHIMURIUM; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DRUG RESISTANCE, BACTERIAL; EVOLUTION, MOLECULAR; MODELS, MOLECULAR; NUCLEOSIDE-PHOSPHATE KINASE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN CONFORMATION; PYRIMIDINES; SALMONELLA TYPHIMURIUM; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; SALMONELLA TYPHIMURIUM;

EID: 0036178687     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(02)00708-6     Document Type: Article

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