Evidence for tolerance following repeated dosing in rats with ciproxifan, but not with A-304121

Life Sciences

Volumn 79, Issue 14, 2006, Pages 1366-1379

  Pan, Jia Bao ^a   Yao, Betty B ^a   Miller, Thomas R ^a   Kroeger, Paul E ^a   Bennani, Youssef L ^b   Komater, Victoria A ^a   Esbenshade, Timothy A ^a   Hancock, Arthur A ^a   Decker, Michael W ^a   Fox, Gerard B ^a  

^a ABBOTT LABORATORIES   (United States)

^b VERTEX PHARMACEUTICALS   (United States)

Author keywords

A 304121; Chronic treatment; Ciproxifan; Histamine H3 receptor inverse agonist; Tolerance

Indexed keywords

2 AMINO 1 [4 [3 (4 CYCLOPROPANECARBONYLPHENOXY)PROPYL] 1 PIPERAZINYL] 1 PROPANONE; CIPROXIFAN; HISTAMINE H3 RECEPTOR ANTAGONIST; METHYLPHENIDATE;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORE TEMPERATURE; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG TOLERANCE; FLUID INTAKE; FOOD INTAKE; GENE EXPRESSION; HYPERACTIVITY; HYPERTHERMIA; LOCOMOTION; MALE; NONHUMAN; RAT; RECEPTOR DENSITY;

ANIMALS; BODY TEMPERATURE; BODY WEIGHT; CENTRAL NERVOUS SYSTEM STIMULANTS; DRINKING; DRUG TOLERANCE; EATING; GENE EXPRESSION; HISTAMINE AGONISTS; HISTAMINE ANTAGONISTS; IMIDAZOLES; MALE; METHYLPHENIDATE; MOTOR ACTIVITY; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, HISTAMINE H3;

RODENTIA;

EID: 33747040235     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.04.002     Document Type: Article

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