D-alanine piperazine-amides: Novel non-imidazole antagonists of the histamine H3 receptor

Inflammation Research

Volumn 52, Issue SUPPL.1, 2003, Pages

  Faghih, R ^a   Phelan, K ^a   Esbenshade, T A ^a   Miller, T R ^a   Kang, C H ^a   Krueger, K M ^a   Yao, B B ^a   Fox, G B ^a   Bennani, Y L ^a   Hancock, A A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 [4 [3 (4 CYCLOPROPANECARBONYLPHENOXY)PROPYL] 1 PIPERAZINYL] 1 PROPANONE; 2 AMINO 1 [4 [3 (4 CYCLOPROPANECARBONYLPHENOXY)PROPYL]PIPERAZIN 1 YL]PROPAN 1 ONE; A 317920; ALANINE; AMIDE; FURAN 2 CARBOXYLIC ACID [2 [4 [3 (4 CYCLOPROPANECARBONYLPHENOXY)PROPYL]PIPERAZIN 1 YL] 1 METHYL 2 OXOETHYL]AMIDE; HISTAMINE H3 RECEPTOR ANTAGONIST; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

BINDING AFFINITY; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM DISEASE; CHEMICAL STRUCTURE; COGNITION; CONFERENCE PAPER; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; LIGAND BINDING; NONHUMAN; RAT; RECEPTOR BLOCKING;

ALANINE; AMIDES; ANIMALS; BINDING, COMPETITIVE; HISTAMINE ANTAGONISTS; HUMANS; INDICATORS AND REAGENTS; KINETICS; PIPERAZINES; RATS; RECEPTORS, HISTAMINE H3; RECOMBINANT PROTEINS;

EID: 12444296545     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110300049     Document Type: Conference Paper

References (8)

1. Hough LB. Genomics meets histamine receptors: new subtypes, new receptors. Mol Pharmacol 2001; 59: 415-19.
2. 3 histamine receptor isoforms: new therapeutical targets in the CNS? Current Opi Invest Drugs 2001; 2: 1428-31.
3. 3-receptor ligands. Part II: Binding preference for D-amino-acids motif. Bioorg Med Chem Lett 2002; 12: 2035-7.
4. Esbenshade TA and Hancock AA. Characterization of histamingergic receptors, in Current Protocols of Pharmacology 2000; 1.19.1-1.19.19.
5. 3 receptor. Mol Pharmacol 1999; 55: 1101-07.
6. 3 receptor agonist. J Pharmacol Exp Ther 1992; 263: 304-10.
7. H3R) antagonists. Inflammation Res (in press).
8. 3R) antagonists with cognition enhancing properties in rats. Inflammation Res (in press).