The co-crystal structure of unliganded bovine α-thrombin and prethrombin-2: Movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding

Protein Science

Volumn 6, Issue 7, 1997, Pages 1438-1448

  Malkowski, Michael G ^a,c   Martin, Philip D ^a   Guzik, Jason C ^a   Edwards, Brian F P ^a,b  

^a WAYNE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Michigan State University   (United States)

Author keywords

Blood coagulation; Prethrombin 2; Protein structure; Serine proteases; X ray crystallography; thrombin

Indexed keywords

AMINO ACID; AMMONIUM SULFATE; APOENZYME; ARGININE; ENZYME INHIBITOR; ENZYME PRECURSOR; FIBRINOPEPTIDE A; GLUTAMIC ACID; ISOLEUCINE; MACROGOL; PRETHROMBIN 2; PROLINE; THROMBIN; TRYPSINOGEN; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CATTLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; HUMAN; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL;

BOS TAURUS; BOVINAE;

EID: 0030802519     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560060708     Document Type: Article

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