Gonadotropin-releasing hormone (GnRH) and its natural analogues: A review

Theriogenology

Volumn 66, Issue 4, 2006, Pages 691-709

  Schneider, Falk ^a   Tomek, Wolfgang ^a   Gründker, Carsten ^b  

^a LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Farm animals; GnRH; Gonadotropin; Hypothalamus; Reproduction

Indexed keywords

ANIMALIA; MAMMALIA;

EID: 33746915125     PISSN: 0093691X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.theriogenology.2006.03.025     Document Type: Review

References (196)

1. Matsuo H., Baba Y., Nair R.M.G., Arimura A., and Schally A.V. Structure of the porcine LH-and FSH-releasing hormone. I. The proposed amino acid sequence. Biochem Biophys Res Commun 43 (1971) 1334-1339
2. Amoss M., Burgus R., Blackwell R., Vale W., Fellows R., and Guillemin R. Purification, amino acid composition and n-terminus of the hypothalamic luteinizing hormone releasing factor (lrf) of ovine origin. Biochem Biophys Res Commun 44 (1971) 205-210
3. Sherwood N.M., Lovejoy D.A., and Coe I.R. Origin of mammalian gonadotropin-releasing hormones. Endocr Rev 14 (1993) 241-254
4. Casañ E.M., Raga F., Bonilla-Musoles F., and Polan M.L. Human oviductal gonadotropin-releasing hormone: possible implications in fertilization, early embryonic development, and implantation. J Clin Endocrinol Metab 85 (2000) 1377-1381
5. Krsmanovic L.Z., Martinez-Fuentes J., Arora K.K., Mores N., Tomic M., Stojilkovic S.S., et al. Local regulation of gonadotroph function by pituitary gonadotropin-releasing hormone. Endocrinology 141 (2000) 1187-1195
6. Gründker C., Günthert A.R., Westphalen S., and Emons G. Biology of the gonadotropin-releasing hormone system in gynaecological cancers. Euro J Endocrinol 146 (2002) 1-14
7. Leung P.C., Cheng C.K., and Zhu X.M. Multi-factorial role of GnRH-I and GnRH-II in the human ovary. Mol Cell Endocrinol 202 (2003) 145-153
8. Limonta P., Moretti R.M., Marelli M.M., and Motta M. The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans. Front Neuroendocrinol 24 (2003) 279-295
9. Emons G., Gründker C., Günthert A.R., Westphalen S., Kavanagh J., and Verschraegen C. GnRH antagonists in the treatment of gynecological and breast cancers. Endocrine Relat Cancer 10 (2003) 291-299
10. Kang S.K., Choi K.C., Yang H.S., and Leung P.C.K. Potential role of gonadotrophin-releasing hormone (GnRH-I) and GnRH-II in the ovary and the ovarian cancer. Endocrine Relat cancer 10 (2003) 169-177
11. Guillemin R. Hypothalamic hormones a.k.a. hypothalamic releasing factors. J Endocrinol 184 (2005) 11-28
12. Millar R.P. GnRHs and GnRH receptors. Anim Reprod Sci 88 (2005) 5-28
13. Pawson A.J., and McNeilly A.S. The pituitary effects of GnRH. Anim Reprod Sci 88 (2005) 75-94
14. Sealfon S.C., Weinstein H., and Millar R.P. Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor. Endocr Rev 18 (1997) 180-205
15. Gorbman A., and Sower S.A. Evolution of the role of GnRH in animal (Metazoan) biology. Gen Comp Endocrinol 134 (2003) 207-213
16. Amano M., Oka Y., Kitamura S., Ikuta K., and Aida K. Ontogenetic development of salmon GnRH and chicken GnRH-II systems in the brain of masu salmon (Oncorhynchus masou). Cell Tissue Res 293 (1998) 427-434
17. Millar R., Lu Z.-L., Pawson A.J., Flanagan C.A., Morgan K., and Maudsley S.R. Gonadotropin-releasing hormone receptors. Endocr Rev 25 (2004) 235-275
18. Okubo K., and Aida K. Gonadotropin-releasing hormone gene products downregulate the expression of their neighboring genes that encode protein tyrosine phosphatases α and ε. Biochem Biophys Res Commun 312 (2003) 531-536
19. Cheon K.W., Lee H.S., Parhar I., and Kang I.S. Expression of the second isoform of gonadotrophin-releasing hormone (GnRH-II) in human endometrium throughout the menstrual cycle. Molec Hum Reprod 7 (2001) 447-452
20. Maiti K., Li J.H., Wang A.F., Acharjee S., Kim W.P., Im W.B., et al. GnRH-II analogs for selective activation and inhibition of non-mammalian and type-II mammalian GnRH receptors. Mol Cells 16 (2003) 173-179
21. Millar R.P. GnRH II and type II GnRH receptors. Trends Endocrinol Metab 14 (2003) 35-43
22. Ramakrishnappa N., Rajamahendran R., Lin Y.M., and Leung P.C.K. GnRH in non-hypothalamic tissues. Anim Reprod Sci 88 (2005) 95-113
23. Clarke I.J., and Pompolo S. Synthesis and secretion of GnRH. Anim Reprod Sci 88 (2005) 29-55
24. Amano M., Takahashi A., Yamanome T., Okubo K., Aida K., and Yamamori K. Molecular cloning of three cDNAs encoding different GnRHs in the brain of barfin flounder. Gen Comp Endocrinol 126 (2002) 325-333
25. Kleine B., Kienle A., Poettich M., Wolfahrt S., Jarry H., and Rossmanith W.G. Analysis of ultrashort feedback regulation in human placental synthesis and secretion of GnRH by human trophoblastic cells. Horm Metab Res 32 (2000) 216-223
26. Rissman E.F. Behavioral regulation of gonadotropin-releasing hormone. Biol Reprod 54 (1996) 413-419
27. Bless E.P., Walker H.J., Yu K.W., Knoll J.G., Moenter S.M., Schwarting G.A., et al. Live view of gonadotropin-releasing hormone containing neuron migration. Endocrinology 146 (2005) 463-468
28. Wirsig-Wiechmann C.R. Function of gonadotropin-releasing hormone in olfaction. Keio J Med 50 (2001) 81-85
29. Montaner A.D., Mongiat L., Lux-Lantos V.A.R., Park M., Fischer W.H., Craig A.G., et al. Structure and biological activity of gonadotropin-releasing hormone isoforms isolated from rat and hamster brains. Neuroendocrinology 74 (2001) 202-212
30. Neill J.D. Minireview: GnRH and GnRH receptor genes in the human genome. Endocrinology 143 (2002) 737-743
31. Temple J.L., Millar R.P., and Rissman E.F. An evolutionarily conserved form of gonadotropin-releasing hormone coordinates energy and reproductive behavior. Endocrinology 144 (2003) 13-19
32. Hiney J.K., Sower S.A., Yu W.H., McCann S.M., and Dees W.L. Gonadotropin-relasing hormone neurons in the preoptic-hypothalamic region of the rat contain lamprey gonadotropin-releasing hormone III, mammalian luteinizing hormone-releasing hormone, or both peptides. Proc Natl Acad Sci USA 99 (2002) 2386-2391
33. Morgan K., and Millar R.P. Evolution of GnRH ligand precursors and GnRH receptors in protochordate and vertebrate species. Gen Comp Endocrinol 139 (2004) 191-197
34. Iwakoshi E., Takuwa-Kuroda K., Fujisawa Y., Hisada M., Ukena K., Tsutsui K., et al. Isolation and characterization of a GnRH-like peptide from octopus vulgaris. Biochem Biophys Res Commun 291 (2002) 1187-1193
35. Gautron J.P., Pattou E., Bauer K., and Kordon C. Preferential distribution of C-terminal fragments of [hydroxyproline9]LHRH in the rat hypocampus and olfactory bulb. Neuroendocrinology 58 (1993) 240-250
36. Montaner A.D., Park M., Fischer W.H., Craig A.G., Chang J.P., Somoza G.M., et al. Primary structure of a novel gonadotropin-releasing hormone in the brain of teleost, pejerrey. Endocrinology 142 (2001) 1453-1460
37. Yamanaka C., Lebrethon M.C., Vandersmissen E., Gerard A., Purnelle G., Lemaitre M., et al. Early prepubertal ontogeny of pulsatile gonadotropin-releasing hormone (GnRH) secretion: I. Inhibitory autofeedback control through prolyl endopeptidase degradation of GnRH. Endocrinology 140 (1999) 4609-4615
38. Adams B.A., Vickers E.D., Warby C., Park M., Fischer W.H., Craig A.G., et al. Three forms of gonadotropin-releasing hormone, including a novel form, in a basal salmonid, Coregonus clupeaformis. Biol Reprod 67 (2002) 232-239
39. Adelman J.P., Mason A.J., Hayflick J.S., and Seeburg P.H. Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin-inhibiting factor in human and rat. Proc Natl Acad Sci USA 83 (1986) 179-183
40. White R.B., Eisen J.A., Kasten T.L., and Fernald R.D. Second gene for gonadotropin-releasing hormone in humans. Proc Natl Acad Sci USA 95 (1998) 305-309
41. Lescheid D.W., Terasawa E., Abler L.A., Urbanski H.F., Warby C.M., Millar R.P., et al. A second form of gonadotropin-releasing hormone (GnRH) with characteristics of chicken GnRH-II is present in the primate brain. Endocrinology 138 (1997) 5618-5629
42. Densmore V.S., and Urbanski H.F. Relative effect of gonadotropin-releasing hormone (GnRH)-I and GnRH-II on gonadotropin release. J Clin Endocrinol Metab 88 (2003) 2126-2134
43. Pawson A.J., Morgan K., Maudsley S.R., and Millar R.P. Type II gonadotrophin-releasing-hormone (GnRH-II) in reproductive biology. Reproduction 126 (2003) 271-278
44. Kasten T.L., White S.A., Norton T.T., Bond C.T., Adelman J.P., and Fernald R.D. Characterization of two new preproGnRH mRNAs in the tree shrew: first evidence for mesencephalic GnRH expression in a placental mammal. Gen Comp Endocrinol 104 (1996) 7-19
45. Rissman E.F., Alones V., Craig-Veit C.B., and Millam J.R. Distribution of chicken II gonadotropin-releasing hormone in mammalian brain. J Comp Neurol 357 (1995) 524-531
46. Yu W.H., Karanth S., Sower S.A., Parlow A.F.P., and McCann S.M. The similarity of FSH-releasing factor to lamprey gonadotropin-releasing hormone III (l-GnRH-III). Proc Soc Exper Biol Med 224 (2000) 87-92
47. Yahalom D., Chen A., Ben-Aroya N., Rahimipour S., Kaganovsky E., Okon E., et al. The gonadotropin-releasing hormone family of neuropeptides in the brain of human, bovine and rat; identification of a third isoform. FEBS Lett 463 (1999) 289-294
48. Moenter S.M., DeFazio R.A., Pitts G.R., and Nunemaker C.S. Mechanisms underlying episodic gonadotropin-releasing hormone secretion. Front Neuroendocrinol 24 (2003) 79-93
49. Piva F., Zanisi M., Motta M., and Martini L. "Ultrashort" control of hypothalamic hormones secretion: a history. J Endocrinol Invest 27 Suppl. 6 (2004) 68-72
50. McCann S.M., Kimura M., Walczewska A., Karranth S., Rettori V., and Yu W.H. Hypothalamic control of FSH and LH by FSH-RF, LHRH, cytokines, leptin and nitric oxide. Neuroimmunomodulation 5 (1998) 193-202
51. Nunemaker C.S., Straume M., Defazio R.A., and Moenter S.M. Gonadotropin-releasing hormone neurons generate interacting rhythms in multiple time domains. Endocrinology 144 (2003) 823-831
52. McNeilly A.S., Crawford J.L., Taragnat C., Nicol L., and McNeilly J.R. The differential secretion of FSH and LH: regulation through genes, feedback and packaging. Reprod Suppl 61 (2003) 463-476
53. Weesner G.D., Harms P.G., McArthur N.H., Wilson J.M., Forrest D.W., Wu T.J., et al. Luteinizing hormone-releasing hormone gene expression in the bovine brain: anatomical localization and regulation by ovarian state. Biol Reprod 49 (1993) 431-436
54. Karsch F.J., Dahl G.E., Evans N.P., Manning J.M., Mayfield K.P., Moenter S.M., et al. Seasonal changes in gonadotropin-reelasing hormone secretion in the ewe: alteration in response to the negative feedback action of estradiol. Biol Reprod 49 (1999) 1377-1383
55. Nett T.M., Turzillo A.M., Baratta M., and Rispoli L.A. Pituitary effects of steroid hormones on secretion of follicle-stimulating hormone and luteinizing hormone. Domest Anim Endocrinol 23 (2002) 33-42
56. Barb C.R. The brain-pituitary-adipocyte axis: role of leptin in modulating neuroendocrine function. J Anim Sci 77 (1999) 1249-1257
57. Dobson H., and Smith R.F. What is stress, and how does it affect reproduction?. Anim Reprod Sci 60-61 (2000) 743-752
58. Wauters M., Considine R.V., and Van Graal L.F. Human leptin: from an adipocyte hormone to an endocrine mediator. Eur J Endocrinol 143 (2000) 293-311
59. Tilbrook A.J., Turner A.I., and Clarke I.J. Stress and reproduction: central mechanisms and sex differences in non-rodent species. Stress 5 (2002) 83-100
60. Barb C.R., Barrett J.B., and Kraeling R.R. Role of leptin in modulating the hypothalamic-pituitary axis and luteinizing hormone secretion in the prepuberal gilt. Domest Anim Endocrinol 26 (2004) 201-214
61. Breen K.M., and Karsch F.J. Does cortisol inhibit pulsatile luteinizing hormone secretion at the hypothalamic or pituitary level?. Endocrinology 145 (2004) 692-698
62. Schneider F., Brüssow K.P., Kanitz E., Otten W., and Tuchscherer A. Maternal reproductive hormone levels after repeated ACTH application to pregnant gilts. Anim Reprod Sci 81 (2004) 313-327
63. Chang W.J., Barb C.R., Kraeling R.R., Rampacek G.B., and Leshin L.S. Involvement of the central noradrenergic system in opioid modulation of luteinizing hormone and prolactin secretion in the pig. Biol Reprod 49 (1993) 176-180
64. Herbison A.E. Noradrenergic regulation of cyclic GnRH secretion. Rev Reprod 2 (1997) 1-16
65. Hoffman G.E., and Berghorn K.A. Gonadotropin-releasing hormone neurons: their structure and function. Sem Reprod Endocrinol 15 (1997) 5-17
66. Malpaux B., Thiery J.C., and Chemineau P. Melatonin and seasonal control of reproduction. Reprod Nutr Dev 39 (1999) 355-366
67. Ortmann O., and Diedrich K. Pituitary and extrapituitary actions of gonadotropin-releasing hormone and its analogues. Hum Reprod Suppl 1 (1999) 194-206
68. Ziecik A.J., Sienkiewicz W., Okrasa S., Kalamarz H., Lakomy M., and Kraeling R.R. Concentration and distribution of neuropeptide Y, galanin, β-endorphin, vasoactive intestinal peptide and gonadotropin-releasing hormone in the hypothalamus of gilts during oestrogen-induced surge secretion of luteinizing hormone. Reprod Dom Anim 34 (1999) 477-487
69. Prunier A., and Quesnel H. Nutritional influences on the hormonal control of reproduction in female pigs. Livest Prod Sci 63 (2000) 1-16
70. McCann SM, Kimura M, Karanth S, Yu W, Rettori V. Role of nitric oxide in the neuroendocrine response to cytokines. In: Gaillard RC, editor. Neuroendocrine-immune interactions, vol. 29. Basel: Karger. Front Horm Res; 2002. p. 117-29.
71. Evans J.J. Modulation of gonadotropin levels by peptides acting at the anterior pituitary gland. Endocr Rev 20 (1999) 46-67
72. Kaiser U.B., Conn P.M., and Chin W.W. Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines. Endocr Rev 18 (1997) 46-70
73. Dalkin A.C., Burger L.L., Aylor A.W., Haisenleder D.J., Workman L.J., Cho S., et al. Regulation of gonadotropin subunit gene transcription by gonadotropin-releasing hormone: measurement of primary transcript ribonucleic acids by quantitative reverse transcription-polymerase chain reaction assays. Endocrinology 142 (2001) 139-146
74. Burger L.L., Haisenleder D.J., Dalkin A.C., and Marshall J.C. Regulation of gonadotropin subunit gene transcription. J Mol Endocrinol 33 (2004) 559-584
75. De Koning J., Lambalk C.B., Helmerhorst F.M., and Helder M.N. Is GnRH self-priming an obligatory feature of the reproductive cycle?. Hum Reprod 16 (2001) 209-214
76. Caraty A., Antoine C., Delaleu B., Locatelli A., Bouchard P., Gautron J.P., et al. Nature and bioactivity of releasing-hormone (GnRH) secreted during the GnRH surge. Endocrinology 136 (1995) 3452-3460
77. D'Occhio M.J., Gifford D.R., Earl C.R., Weatherly T., and von Rechenberg W. Pituitary and ovarian responses of post-partum acyclic beef cows to continuous long-term GnRH and GnRH agonist treatment. J Reprod Fert 85 (1989) 495-502
78. D'Occhio M.J., Fordyce G., Whyte T.R., Jubb T.F., Fitzpatrick L.A., Cooper N.J., et al. Use of GnRH agonist implants for long-term suppression of fertility in extensively managed heifers and cows. Anim Reprod Sci 74 (2002) 151-162
79. Gong J.G., Campbell B.K., Bramley T.A., Gutierrez C.G., Peters A.R., and Webb R. Suppression in the secretion of follicle-stimulating hormone and luteinizing hormone, and ovarian follicle development in heifers continuously infused with a gonadotropin-releasing hormone agonist. Biol Reprod 55 (1996) 68-74
80. Viczarra J.A., Wettemann R.P., Braden D.T., Turzillo A.M., and Nett T.M. Effect of gonadotropin-releasing hormone (GnRH) pulse frequency on serum and pituitary concentrations of luteinizing hormone and follicle-stimulating hormone, GnRH receptors, and messenger ribonucleic acid for gonadotropin subunits in cows. Endocrinology 138 (1997) 594-601
81. Schneider F., Bellmann A., Becker F., Bambang Poernomo S., Rehfeldt C., Nürnberg G., et al. Gonadotropin release in periovulatory heifers after GnRH analogs measured by two types of immunoassays. Exp Clin Endocrinol Diabetes 110 (2002) 235-244
82. Aspden W.J., Jackson A., Trigg T.E., and D'Occhio M.J. Pituitary expression of LHbeta- and FSHbeta-subunit mRNA, cellular distribution of LHbeta-subunit mRNA and LH and FSH synthesis during and after treatment with a gonadotrophin-releasing hormone agonist in heifers. Reprod Fertil Dev 15 (2003) 149-156
83. Padmanabhan V., and McNeilly A.S. Is there an FSH-releasing factor?. Reproduction 121 (2001) 21-30
84. Lumpkin M.D., Moltz J.H., Yu W.H., Samson W.K., and McCann S.M. Purification of FSH-releasing factor: its dissimilarity from LHRH of mammalian, avian and piscian origin. Brain Res Bull 18 (1987) 175-178
85. Millar R., Lowe S., Conklin D., Pawson A., Maudsley S., Troskie B., et al. A novel mammalian receptor for the evolutionarily conserved type II GnRH. Proc Nat Acad Soc USA 98 (2001) 9637-9641
86. Yu W.H., Karanth S., Walczewska A., Sower S.A., and McCann S.M. A hypothalamic follicle stimulating hormone releasing decapeptide in the rat. Proc Natl Acad Sci USA 94 (1997) 9499-9503
87. Dees W.L., Dearth R.K., Hooper R.N., Brinsko S.P., Romano J.E., Rahe H., et al. Lamprey gonadotropin-releasing hormone-III selectively follicle stimulating hormone in the bovine. Domest Anim Endocrinol 20 (2001) 279-288
88. Gault P.M., Morgan K., Pawson A.J., Millar R.P., and Lincoln G.A. Sheep exhibit novel variations in the organization of the mammalian type II gonadotropin-releasing hormone receptor gene. Endocrinology 145 (2004) 2362-2374
89. Padmanabhan V., Brown M.B., Dahl G.E., Evans N.P., Karsch F.J., and Mauger D.T. Neuroendocrine control of follicle-stimulating hormone (FSH) secretion: III. Is there a gonadotropin-releasing hormone-independent component of episodic FSH secretion in ovariectomized and luteal phase ewes?. Endocrinology 144 (2003) 1380-1392
90. Gharib S.D., Wierman M.E., Shupnik M.A., and Chin W.W. Molecular biology of the pituitary gonadotropins. Endocr Rev 11 (1990) 177-199
91. Rispoli L.A., and Nett T.M. Pituitary gonadotropin-releasing hormone (GnRH) receptor: Structure, distribution and regulation of expression. Anim Reprod Sci 88 (2005) 57-74
92. Nett T.M., Cermak D., Braden T., Manns J., and Niswender G.D. Receptors for GnRH and estradiol and pituitary content of gonadotropins in beef cows. I. Changes during the estrous cycle. Domest Anim Endocrinol 4 (1987) 123-132
93. Wu J.C., Sealfon S.C., and Miller W.L. Gonadal hormones and gonadotropin-releasing-hormone (GnRH) alter messenger ribonucleic acid levels for GnRH receptors in sheep. Endocrinology 134 (1994) 1846-1850
94. Brooks J., and McNeilly A.S. Regulation of gonadotrophin-releasing hormone receptor expression in the ewe. Anim Reprod Sci 42 (1996) 89-98
95. Turzillo A.M., and Nett T.M. Regulation of GnRH receptor gene expression in sheep and cattle. J Reprod Fertil Suppl 54 (1999) 75-86
96. Cheng K.W., Cheng C.K., and Leung P.C. Differential role of PR-A and PR-B isoforms in transcription regulation of human GnRH receptor gene. Mol Endocrinol 15 (2001) 2078-2092
97. Reinhart J., Mertz L.M., and Catt K.J. Molecular cloning and expression of the rat pituitary gonadotropin-releasing hormone receptor. J Biol Chem 267 (1992) 21281-21284
98. Tsutsumi M., Zhou W., Millar R.P., Mellon P.L., Roberts J.L., Flanagan C.A., et al. Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor. Mol Endocrinol 6 (1992) 1163-1169
99. Eidne K.A., Sellar R.E., Couper G., Anderson L., and Taylor P.L. Molecular cloning and characterisation of the rat pituitary gonadotropin-releasing hormone (GnRH) receptor. Mol Cell Endocrinol 90 (1992) R5-R9
100. Kaiser U.B., Zhao D., Cardona G.R., and Chin W.W. Isolation and characterization of cDNAs encoding the rat pituitary gonadotropin-releasing hormone receptor. Biochem Biophys Res Commun 189 (1992) 1645-1652
101. Brooks J., Taylor P.L., Saunders P.T.K., Eidne K.A., Struthers W.J., and McNeilly A.S. Cloning and sequencing of the sheep pituitary gonadotropin-releasing hormone receptor and changes in expression of its mRNA during the estrous cycle. Mol Cell Endocrinol 94 (1993) R23-R27
102. Illing N., Jacobs G.F., Becker I.I., Flanagan C.A., Davidson J.S., Eales A., et al. Comparative sequence analysis and functional characterization of the cloned sheep gonadotropin-releasing-hormone receptor reveal differences in primary structure and ligand specificity among mammalian receptors. Biochem Biophys Res Commun 196 (1993) 745-751
103. Chi L., Zhou W., Prikhozhan A., Flanagan C., Davidson J.S., Golembo M., et al. Cloning and characterization of the human GnRH receptor. Mol Cell Endocr 91 (1993) R1-R6
104. Kakar S.S., Musgrove L.C., Devor D.C., Sellers J.C., and Neill J.D. Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor. Biochem Biophys Res Commun 30 (1992) 289-295
105. Kakar S.S., Rahe C.H., and Neill J.D. Molecular cloning, sequencing, and characterizing the bovine receptor for gonadotropin releasing hormone (GnRH). Domest Anim Endocrinol 10 (1993) 335-342
106. Weesner G.D., and Matteri R.L. Nucleotide sequence of luteinizing hormone-releasing hormone (LHRH) receptor cDNA in the pig pituitary (Rapid Communication). J Anim Sci 72 (1994) 1911
107. Wess J. G-protein-coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G protein recognition. FASEB J 11 (1997) 346-354
108. Ji T.H., Grossmann M., and Ji I. G-protein coupled receptors. I. Diversity of receptor-ligand interactions. J Biol Chem 273 (1998) 17299-17302
109. Gether U. Uncovering molecular mechanisms involved in activation of G protein coupled receptors. Endocr Rev 21 (2000) 90-113
110. Naor Z., Millar R.P., and Seger R. Signaling of GnRH receptor in pituitary gonadotrophs. In: GnRH analogs in human reproduction-state of the art 2005 (2005), Parthenon Publishing Group p. 1-13
111. Haisenleder D.J., Yasin M., Dalkin A.C., Gilrain C., and Marshall J.C. GnRH regulates steroidogenic factor-1 (SF-1) gene expression in the rat pituitary. Endocrinology 137 (1996) 5719-5722
112. Halvorson L.M. Transcriptional regulation of the LH beta gene by gonadotropin-releasing hormone and the protein kinase C system. Vitam Horm 60 (2000) 195-227
113. Cheng K.W., and Leung P.C. The expression, regulation and signal transduction pathways of the mammalian gonadotropin-releasing hormone receptor. Can J Physiol Pharmacol 78 (2000) 1029-1052
114. McArdle C.A., Franklin J., Green L., and Hislop J.N. Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors. J Endocr 173 (2002) 1-11
115. Cheng C.K., and Leung P.C. Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans. Endocr Rev 26 (2005) 283-306
116. Neill J.D., Duck L.W., Sellers J.C., and Musgrove L.C. A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates. Biochem Biophys Res Commun 282 (2001) 1012-1018
117. Millar R., Conklin D., Lofton-Day C., Hutchinson E., Troskie B., Illing N., et al. A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript. J Endocrinol 162 (1999) 117-126
118. Flanagan C.A., Millar R.P., and Illing N. Advances in understanding gonadotrophin-releasing hormone receptor structure and ligands interactions. Rev Reprod 2 (1997) 113-120
119. Wang L., Bogerd J., Choi H.S., Seong J.Y., Soh J.M., Chun S.Y., et al. Three distinct types of GnRH receptor characterized in the bullfrog. Proc Natl Acad Soc USA 98 (2001) 361-366
120. Bull P., Morales P., Huyser C., Socias T., and Castellon E.A. Expression of GnRH receptor in mouse and rat testicular germ cells. Mol Hum Reprod 6 (2000) 582-586
121. Stojilkovic S.S., Reinhart J., and Catt K.J. Gonadotropin releasing hormone receptors: structure and signal transduction pathways. Endocr Rev 15 (1994) 462-499
122. Bauer-Dantoin A.C., and Jameson J.L. Gonadotropin-releasing-hormone messenger ribonucleic acid expression in the ovary during the rat estrous cycle. Endocrinology 136 (1995) 4432-4438
123. Kakar S.S., Grizzle W.E., and Neill J.D. The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary. Endocrinology 106 (1995) 145-149
124. Wolfahrt S., Kleine B., Jarry H., and Rossmanith W.G. Endogenous regulation of the GnRH receptor by GnRH in the placenta. Mol Hum Reprod 7 (2001) 89-95
125. Chou C.S., Beristain A.G., MacCalman C.D., and Leung P.C. Cellular localization of gonadotropin-releasing hormone (GnRH) I and GnRH II in first-trimester human placenta and deciduas. J Clin Endocrinol Metab 89 (2004) 1459-1466
126. Gründker C., Günthert A.R., Millar R.P., and Emons G. Expression of gonadotropin-releasing hormone II (GnRH-II) receptor in human endometrial and ovarian cancer cells and effect of GnRH-II on tumor cell proliferation. J Clin Endocrinol Metab 87 (2002) 1427-1430
127. Enomoto M., Endo D., Kawashima S., and Park M.K. Human type II GnRH receptor mediates effects of GnRH on cell proliferation. Zool Sci 21 (2004) 763-770
128. Eicke N., Günthert A.R., Viereck V., Siebold D., Béhé M., Becker T., et al. GnRH-II receptor-like antigenicity in human placenta and in cancers of human reproductive organs. Eur J Endocrinol 153 (2005) 605-612
129. Morgan K., Conklin D., Pawson A.J., Sellar R., Ott T.R., and Millar R.P. A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q. 12. Endocrinology 144 (2003) 423-436
130. Neill J.D., Musgrove L.C., and Duck L.W. Newly recognized GnRH receptors: function and relative role. Trends Endocrinol Metab 15 (2004) 383-392
131. Enomoto M., and Park M.K. GnRH as a cell proliferation regulator: mechanism of action and evolutionary implications. Zool Sci 21 (2004) 1005-1013
132. Whitelaw P.F., Eidne K.A., Sellar R., Smyth C.D., and Hillier S.G. Gonadotropin-releasing hormone receptor messenger ribonucleic acid expression in rat ovary. Endocrinology 136 (1995) 172-179
133. Canipari R. Oocyte-granulosa cell interactions. Hum Reprod Update 6 (2000) 279-289
134. Jones S.W. Chicken II luteinizing hormone-releasing hormone inhibits the M-current of bullfrog sympathetic neurons. Neurosci Lett 80 (1987) 180-184
135. Igarashi M., and McCann S.M. A hypothalamic follicle stimulating hormone releasing factor. Endocrinology 79 (1964) 446-452
136. Schally A.V., Arimura A., Redding T.W., Debeljuk L., Carter W., DuPont A., et al. Re-examination of porcine and bovine hypothalamic fractions for additional luteinizing and follicle stimulating hormone-releasing activities. Endocrinology 98 (1976) 380-391
137. Gault P.M., Maudsley S., and Lincoln G.A. Evidence that gonadotropin-releasing hormone II is not a physiological regulator of gonadotropin secretion in mammals. J Neuroendocrinol 15 (2003) 831-839
138. McCann SM, Yu WH. FSH-releasing peptides. US Patent 6,300,471 (2001).
139. McCann S.M., Karanth S., Mastronardi C.A., Dees W.L., Childs G., Miller R., et al. Control of gonadotropin secretion by follicle-stimulating hormone-releasing factor, luteinizing hormone-releasing hormone, and leptin. Arch Med Res 32 (2001) 476-485
140. Kovacs M., Seprodi J., Koppan M., Horvath J.E., Vincze B., Teplan I., et al. Lamprey gonadotropin hormone-releasing hormone-III has no selective follicle-stimulating hormone-releasing effect in rats. J Neuroendocrinol 14 (2002) 647-655
141. Amstalden M., Zieba D.A., Garcia M.R., Stanko R.L., Welsh Jr. T.H., Hansel W.H., et al. Evidence that lamprey GnRH-III does not release FSH selectively in cattle. Reproduction 127 (2004) 35-43
142. Heredi-Szabo K., Lubke J., Toth G., Murphy R.F., and Lovas S. Importance of the central region of lamprey gonadotropin-releasing hormone III in the inhibition of breast cancer cell growth. Peptides 26 (2005) 419-422
143. Kauffman A.S., and Rissman E.F. The evolutionarily conserved gonadotropin-releasing hormone II modifies food intake. Endocrinology 145 (2004) 686-691
144. Pell J.M., and Aston R. Principles of immunomodulation. Livestock Prod Sci 42 (1995) 123-133
145. Thatcher W.W., Drost M., Savio J.D., Macmillan K.L., Entwistle K.W., Schmitt E.J., et al. New clinical uses of GnRH and its analogues in cattle. Anim Reprod Sci 33 (1993) 27-49
146. Peters A.R. Veterinary clinical application of GnRH-questions of efficacy. Anim Reprod Sci 88 (2005) 155-167
147. Herbert C.A., and Trigg T.E. Applications of GnRH in the control and management of fertility in female animals. Anim Reprod Sci 88 (2005) 141-153
148. Kittok R.J., Britt J.H., and Convey E.M. Endocrine response after GnRH in luteal phase cows and cows with follicular cysts. J Anim Sci 37 (1973) 985-989
149. Cantley T.C., Garverick H.A., Bierschwal C.J., Martin C.E., and Youngquist R.S. Hormonal responses of dairy cows with ovarian cysts to GnRH. J Anim Sci 41 (1975) 1666-1673
150. Bartolome J.A., Sozzi A., McHale J., Melendez P., Arteche A.C.M., Silvestre F.T., et al. Resynchronisation of ovulation and timed insemination in lactating dairy cows, II. assigning protocols according to stages of the estrous cycle, or presence of ovarian cysts or anestrus. Theriogenology 63 (2005) 1628-1642
151. Hyland J.H., Wright P.J., Clarke I.J., Carson R.S., Langsford D.A., and Jeffcot L.B. Infusion of gonadotrophin-releasing hormone (GnRH) induces ovulation and fertile oestrus in mares during seasonal anoestrus. J Reprod Fertil Suppl 35 (1987) 211-222
152. Mumford E.L., Squires E.L., Jöchle W., Harrison L.A., Nett T.M., and Trigg T.E. Use of deslorelin short-term implants to induce ovulation in cycling mares during three consecutive estrous cycles. Anim Reprod Sci 39 (1995) 129-140
153. Brüssow K.P., Jöchle W., and Hühn U. Control of ovulation with a GnRH analog in gilts and sows. Theriogenology 46 (1996) 925-934
154. Chebel R., Santos J.E.P., Cerri R.L.A., Juchem S., Galvao K.N., and Thatcher W.W. Effect of resynchronization with GnRH on day 21 after artificial insemination on pregnancy rate and pregnancy loss in lactating dairy cows. Theriogenology 60 (2003) 1389-1399
155. Ambrose J.D., Pires M.F., Moreira F., Diaz T., Binelli M., and Thatcher W.W. Influence of deslorelin (GnRH-agonist) implant on plasma progesterone, first wave dominant follicle and pregnancy in dairy cattle. Theriogenology 50 (1998) 1157-1170
156. Davis T.L., Mussard M.L., Jiminez-Severiano H., Enright W.J., and Kinder J.E. Chronic treatment with an agonist of gonadotropin-releasing hormone enhances luteal function in cattle. Biol Reprod 69 (2003) 398-403
157. Hampton J.H., Bader J.F., Lamberson W.R., Smith M.F., Youngquist R.S., and Garverick H.A. Gonadotropin requirements for dominant follicle selection in GnRH-agonist treated cows. Reproduction 127 (2004) 695-703
158. Beck N.F.G., Peters A.R., and Williams S.P. The effect of GnRH analogue (buserelin) treatment on day 12 post mating on the reproductive performance of ewes. Anim Prod 58 (1994) 243-247
159. Peters A.R., Martinez T.A., and Cook A.J. A meta-analysis of studies of the effect of GnRH 11-4 days after insemination on pregnancy rates in cattle. Theriogenology 54 (2000) 1317-1327
160. Newcombe J.R., Martinez T.A., and Peters A.R. The effect of the gonadotropin-releasing hormone analog, buserelin, on pregnancy rates in horses and pony mares. Theriogenology 55 (2001) 1619-1631
161. Unger C., Schneider F., Hoppen H.O., Becker F., Nürnberg G., and Kanitz W. Pregnancy rates in mares after application of gonadotropin releasing hormone analogue, Buserelin, in warmblood mares. Theriogenology 58 (2002) 635-638
162. Yavas Y., and Walton J.S. Induction of ovulation in post partum suckled beef cows: a review. Theriogenology 54 (2000) 1-23
163. Schneider F., and Rehbock F. Induction of fertile cycles in the Blackhead sheep during the anoestrus period. Arch Anim Breed 46 (2003) 47-61
164. Bartlewski P.M., Aravindakshan J., Beard A.P., Nelson M.L., Batiasta-Arteaga S., Cook J., et al. Effects of medroxyprogesterone acetate (MAP) on ovarian antral follicle development, gonadotrophin secretion and response to ovulation induction with gonadotrophin-releasing hormone (GnRH) in seasonally anoestrous ewes. Anim Reprod Sci 81 (2004) 63-75
165. Burke J.M., De La Sota R.L., Risco C.A., Staples C.R., Schmitt E.J.P., and Thatcher W.W. Evaluation of timed insemination using a gonadotropin-releasing hormone agonist in lactating dairy cows. J Dairy Sci 79 (1996) 1385-1393
166. Stevenson J.S., Kobayashi Y., and Thompson K.E. Reproductive performance of dairy cows in various programmed breeding systems including Ovsynch and combinations of gonadotropin-releasing hormone and prostaglandin F2. J Dairy Sci 99 (1999) 506-515
167. Bartolome J.A., Silvestre F.T., Kamimura S., Arteche A.C.M., Melendez P., Kelbert D., et al. Resynchronisation of ovulation and timed insemination in lactating dairy cows, I. use of the Ovsynch and Heatsynch protocols after non-pregnancy diagnosis by ultrasonography. Theriogenology 63 (2005) 1617-1627
168. Deligiannis C., Valasi I., Rekkas C.A., Goulas P., Theodosiadou E., Lainas T., et al. Synchronization of ovulation and fixed time intrauterine insemination in ewes. Reprod Domest Anim 40 (2005) 6-10
169. Pursley J.R., Mee M.O., and Wiltbank M.C. Synchronization of ovulation in dairy cows using PGF2α and GnRH. Theriogenology 44 (1995) 915-923
170. Twagiramungu H., Guilbault L.A., and Dufour J.J. Synchronization of ovarian follicular waves with a gonadotropin-releasing hormone agonist to increase the precision of estrus in cattle: a review. J Anim Sci 73 (1995) 3141-3151
171. Gong J.G., Bramley T.A., Gutierrez C.G., Peters A.R., and Webb R. Effects of chronic treatment with gonadotrophin-releasing hormone agonist on peripheral concentrations of FSH and LH, and ovarian function in heifers. J Reprod Fertil 105 (1995) 263-270
172. Maclellan L.J., Bergfeld E.G.M., Earl C.R., Fitzpatrick L.A., Aspden W.J., Kinder J.E., et al. Influence of the luteinizing hormone-releasing hormone agonist, deslorelin, on patterns of estradiol-17β and luteinizing hormone secretion, ovarian follicular responses to superstimulation with follicle-stimulating hormone, and recovery and in vitro development of oocytes in heifer calves. Biol Reprod 56 (1997) 878-884
173. Rajamahendran R., Ambrose J.D., Schmitt E.J., Thatcher M.J., and Thatcher W.W. Effects of buserelin injection and deslorelin (GnRH-agonist) implants on plasma progesterone, LH, accessory CL formation, follicle and corpus luteum dynamics in Holstein cows. Theriogenology 50 (1998) 1141-1155
174. D'Occhio M.J., Fordyce G., Whyte T.R., Aspden W.J., and Trigg T.E. Reproductive responses of cattle to GnRH agonists. Anim Reprod Sci 60-61 (2000) 433-442
175. Schneider F., Heleil B., Alm H., Torner H., Becker F., Viergutz T., et al. Endocrine, morphological, and cytological effects of a depot GnRH agonist in bovine. Anim Reprod Sci 92 (2006) 9-28
176. Adams T.E. Using gonadotropin-releasing hormone (GnRH) and GnRH analogs to modulate testis function and enhance the productivity of domestic animals. Anim Reprod Sci 88 (2005) 127-139
177. Xue J.L., Dial G.D., Bartsh S., Kerkeart B., Squires E.J., Marsh W.E., et al. Influence of a gonadotropin-releasing hormone agonist on circulating concentrations of luteinizing hormone and testosterone and tissue concentrations of compounds associated with boar taint. J Anim Sci 72 (1994) 1290-1298
178. Schneider F., Falkenberg H., Kuhn G., Nurnberg K., Rehfeldt C., and Kanitz W. Effects of treating young boars with a GnRH depot formulation on endocrine functions, testis size, boar taint, carcass composition and muscular structure. Anim Reprod Sci 50 (1998) 69-80
179. Magdwick S., Evans A.C.O., and Beard A.P. Treating heifers with GnRH from 4 to 8 weeks of age advanced growth and the age at puberty. Theriogenology 63 (2005) 2323-2333
180. Esbenshade K.L., and Britt J.H. Active immunization of gilts against gonadotropin-releasing hormone: effects on secretion of gonadotropins. reproductive function, and responses to agonists of gonadotropin-releasing hormone. Biol Reprod 33 (1985) 569-577
181. Prendiville D.J., Enright W.J., Crowe M.A., Finnerty M., and Roche J.F. Normal or induced secretory patterns of luteinising hormone and follicle-stimulating hormone in anoestrous gonadotrophin-releasing hormone-immunised and cyclic control heifers. Anim Reprod Sci 45 (1996) 177-190
182. Stevens J.D., Sosa J.M., DeAvila D.M., Oatley J.M., Bertrand K.P., Gaskins C.T., et al. Luteinizing-hormone-releasing hormone fusion protein vaccines block estrous cycle activity in beef heifers. J Anim Sci 83 (2005) 152-159
183. Brown B.W., Mattner P.E., Carroll P.A., Hoskinson R.M., and Rigby R.D.G. Immunization of sheep against GnRH early in life: effects on reproductive function and hormones in ewes. J Reprod Fertil 103 (1995) 131-135
184. Mariana J.C., Monniaux D., Craty A., Pisselet C., Fontaine J., and Solari A. Immunization of sheep against GnRH early in life: effects on gonadotropins, follicular growth and responsiveness of granulosa cells to FSH and IGF-I in two breeds of sheep with different prolificacy (Romanov and Ile-de-France). Domest Anim Endocrinol 15 (1998) 195-207
185. Tast A., Love R.J., Clarke W., and Evans G. Effects of active and passive gonadotropin-releasing hormone immunization on recognition and establishment of pregnancy in pigs. Reprod Fertil Dev 12 (2000) 277-282
186. Driancourt M.A., Locatelli A., and Prunier A. Effects of gonadotrophin deprivation on follicular growth in gilts. Reprod Nutr Dev 35 (1995) 663-673
187. Dobson H., Campbell B.K., and Scaramuzzi R.J. Use of a GnRH antagonist in conjunction with low amplitude, high frequency LH pulses to induce follicular growth without an LH surge and ovulation. Anim Reprod Sci 46 (1997) 213-222
188. Fike K.E., Bergfeld E.G., Cupp A.S., Kojima F.N., Mariscal V., Sanchez T., et al. Gonadotropin secretion and ovarian follicles during oestrous cycles in heifers treated with luteinizing hormone releasing hormone antagonist. Anim Reprod Sci 49 (1997) 83-100
189. Patterson-Day D.J., Geisert R.D., Hill C.M., Minton J.E., McCann J.P., and Morgan G.L. GnRH antagonist inhibition of luteinizing hormone secretion and ovulation in the pig. Anim Reprod Sci 49 (1997) 207-214
190. Oussaid B., Mariana J.C., Poulin N., Fontaine J., Lonergan P., Beckers J.F., et al. Reduction of the developmental competence of sheep oocytes by inhibition of LH pulses during the follicular phase with a GnRH antagonist. J Reprod Fertil 117 (1999) 71-77
191. Brüssow K.P., Schneider F., and Nürnberg G. Alteration of gonadotrophin and steroid hormone release, and ovarian function by a GnRH antagonist in gilts. Anim Reprod Sci 66 (2001) 117-128
192. Gautron J.P., Gras C., and Enjalbert A. Molecular polymorphism of native gonadotropin-releasing hormone (GnRH) is restricted to mammalian GnRH and [hydroxyproline] GnRH in the developing rat brain. Neuroendocrinology 81 (2005) 69-86
193. Kauffold J., Schneider F., Zaremba W., and Brüssow K.P. Lamprey GnRH-III (l-GnRH-III) selectively elicits FSH response after administration to barrows. Reprod Domest Anim 40 (2005) 475-479
194. Porter M.B., Cleaver B.D., Peltier M., Robinson G., Thatcher W.W., and Sharp D.C. Comparative study between pony mares and ewes evaluating gonadotrophic response to administration of gonadotrophin-releasing hormone. J Reprod Fertil 110 (1997) 219-229
195. Khosravi S., and Leung P.C. Differential regulation of gonadotropin-releasing hormone (GnRH)I and GnRHII messenger ribonucleic acid by gonadal steroids in human granulosa luteal cells. J Clin Endocrinol Metab 88 (2003) 663-672
196. Siler-Khodr T.M., Yu F.Q., Wei P., Tao S.X., and Liu Y.X. Contraceptive action of a gonadotropin-releasing hormone II analog in the rhesus monkey. J Clin Endocrinol Metab 89 (2004) 4513-4520