GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs

European Journal of Endocrinology

Volumn 153, Issue 4, 2005, Pages 605-612

  Eicke, Nicola ^c   Günthert, Andreas ^c   Viereck, Volker ^c   Sebold, Doreen ^c   Béhé, Martin ^a   Becker, Tamara ^b   Emons, Günter ^c   Grünker, Carsten ^c  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b GERMAN PRIMATE CENTER   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CETRORELIX; CYSTEINE; GONADORELIN AGONIST; GONADORELIN DERIVATIVE; GONADORELIN RECEPTOR; GONADORELIN[6 DEXTRO LYSINE]; GONADORELIN[6 DEXTRO LYSINE](4 ACIDOBENZOYL) N HYDROXYSUCCINIMIDE; IODINE 125; KEYHOLE LIMPET HEMOCYANIN; POLYCLONAL ANTIBODY; RECEPTOR ANTIBODY; TRIPTORELIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ANTIGEN DETECTION; ANTIGENICITY; ARTICLE; BINDING COMPETITION; BINDING SITE; CANCER CELL CULTURE; CELL MEMBRANE; CONTROLLED STUDY; CROSS REACTION; ENDOMETRIUM; GENITAL TRACT CANCER; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; IMMUNOHISTOLOGY; ISOTOPE LABELING; MARMOSET; NONHUMAN; OVARY CANCER; PHOTOAFFINITY LABELING; PHOTOCHEMISTRY; PLACENTA; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DOMAIN; PROTEIN FUNCTION; SEQUENCE DATABASE; TISSUE SECTION; WESTERN BLOTTING;

ANIMALS; ANTIGENS; BLOTTING, WESTERN; CALLITHRIX; CELL LINE, TUMOR; FEMALE; GENITAL NEOPLASMS, FEMALE; GENITAL NEOPLASMS, MALE; GONADOTROPIN-RELEASING HORMONE; HUMANS; MALE; OVARY; PLACENTA; RECEPTORS, LHRH;

EID: 27644508860     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.1.02005     Document Type: Article

References (26)

1. Gründker C, Günthert AR, Westphalen S & Emons G. Biology of the gonadotropin-releasing hormone (GnRH) system in gynecological cancers. European Journal of Endocrinology 2002 146 1-14.
2. Emons G, Ortmann O, Becker M, Irmer G, Springer B, Laun R, Hölzel F, Schulz KD & Schally AV. High affinity binding and direct antiproliferative effects of LHRH analogues in human ovarian cancer cell lines. Cancer Research 1993 54 5439-5446.
3. Emons G, Schröder B, Ortmann O, Westphalen S, Schulz KD & Schally AV. High affinity binding and direct antiproliferative effects of luteinizing hormone-releasing hormone analogs in human endometrial cancer cell lines. Journal of Clinical Endocrinology and Metabolism 1993 77 1458-1464.
4. Irmer G, Bürger C, Müller R, Ortmann O, Peter U, Kakar SS, Neill JD, Schulz KD & Emons G. Expression of the messenger RNAs for luteinizing hormone-releasing hormone (LHRH) and its receptor in human ovarian epithelial carcinoma. Cancer Research 1995 55 817-822.
5. Emons G, Ortmann O, Schulz KD & Schally AV. Growth-inhibitory actions of luteinizing hormone releasing hormone on tumor cells. Trends in Endocrinology and Metabolism 1997 8 355-362.
6. Gründker C, Günthert AR, Millar RP & Emons G. Expression of gonadotropin-releasing hormone II (GnRH-II) receptor in human endometrial and ovarian cancer cells and effects of GnRH-II on tumor cell proliferation. Journal of Clinical Endocrinology and Metabolism 2002 87 1427-1430.
7. Völker P, Gründker C, Schmidt O, Schulz KD & Emons G. Expression of receptors for luteinizing hormone-releasing hormone in human ovarian and endometrial cancers: frequency, autoregulation and correlation with direct antiproliferative activity of LHRH analogues. American Journal of Obstetrics and Gynecology 2002 186 171-179.
8. Gründker C, Schlotawa L, Viereck V, Eicke N, Horst A, Kairies B & Emons G. The antiproliferative effects of GnRH antagonist Cetrorelix and of GnRH-II on human endometrial and ovarian cancer cells are not mediated through the GnRH type I (GnRH-I) receptor. European Journal of Endocrinology 2004 151 141-149.
9. Enomoto M, Endo D, Kawashima S & Park MK. Human type II GnRH receptor mediates effects of GnRH on cell proliferation. Zoological Science 2004 21 763-770.
10. Choi KC, Auersperg N & Leung PCK. Expression and anti-proliferative effect of a second form of gonadotropin-releasing hormone in normal and neoplastic ovarian surface epithelial cells. Journal of Clinical Endocrinology and Metabolism 2001 86 5075-5078.
11. Millar R, Lowe S, Conklin D, Pawson A, Maudsley S, Troskie B, Ott T, Millar M, Lincoln G, Sellar R, Faurholm B, Scobie G, Kuestner R, Terasawa E & Katz A. A novel mammalian receptor for the evolutionarily conserved type II GnRH. PNAS 2001 98 9636-9641.
12. Millar RP, Conklin D, Lofton-Day C, Hutchinson E, Troskie B, Illing N, Sealfon SC & Hapgood J. A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript. Journal of Endocrinology 1999 162 117-126.
13. Neill JD, Duck LW, Sellers JC & Musgrove LC. A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates. Biochemical and Biophysical Research Communications 2001 282 1012-1018.
14. Neill JD. GnRH and GnRH receptor genes in the human genome. Endocrinology 2002 143 737-743.
15. Millar RP. GnRH II and type II GnRH receptors. Trends in Endocrinology and Metabolism 2003 14 35-43.
16. Morgan K, Conklin D, Pawson AJ, Sellar R, Ott TR & Millar RP. A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12. Endocrinology 2003 144 423-436.
17. Hazum E. Photo-affinity inactivation of gonadotropin releasing hormone receptors. FEBS Letters 1981 128 111-113.
18. Clayton RN, Shakespear RA, Duncan JA, Marshall JC, Munson PJ & Rodbard D. Radioiodinated nondegradable gonadotropin-releasing hormone analogs: new probes for the investigation of pituitary gonadotropin-releasing hormone receptors. Endocrinology 1979 105 1369-1376.
19. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970 227 680-685.
20. Gault PM, Morgan K, Pawson AJ, Millar RP & Lincoln GA. Sheep exhibit novel variations in the organization of mammalian type II gonadotropin-releasing hormone receptor gene. Endocrinology 2004 145 2362-2374.
21. Faurholm B, Millar RP & Katz AA. The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci. Genomics 2001 78 15-18.
22. Neill JD, Musgrove LC & Duck LW. Newly recognized GnRH receptors: function and relative role. Trends in Endocrinology and Metabolism 2004 15 383-392.
23. Ling K, Wang P, Zhao J, Wu Y-L, Cheng Z-J, Ubi GX, Hu W, Ma L & Pei G. Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors. PNAS 1999 96 7922-7927.
24. Siler-Khodr TM & Grayson M. Action of chicken II GnRH on the human placenta. Journal of Clinical Endocrinology and Metabolism 2001 86 804-810.
25. 8]gonadotropin-releasing hormone (chicken GnRH-II) mRNA in goldfish: evidence for two distinct genes. General and Comparative Endocrinology 1997 107 262-272.
26. Van Biljon W, Wykes S, Scherer S, Krawetz SA & Hapgood J. Type II gonadotropin-releasing hormone receptor transcripts in human sperm. Biology of Reproduction 2002 67 1741-1749.