Synthesis and secretion of GnRH

Animal Reproduction Science

Volumn 88, Issue 1-2 SPEC. ISS., 2005, Pages 29-55

  Clarke, Iain J ^a,b   Pompolo, Sueli ^a  

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Estrogen; GnRH; Gonadotropins; Neuroendocrinology; Reproduction

Indexed keywords

ANIMALIA;

EID: 24044516216     PISSN: 03784320     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anireprosci.2005.05.003     Document Type: Article

References (231)

1. J.P. Adelman, A.J. Mason, J.S. Hayflick, and P.H. Seeburg Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin- releasing hormone and prolactin release-inhibiting factor in human and rat Proc. Natl. Acad. Sci. U.S.A. 83 1986 179 183
2. M. Amoss, R. Burgus, R. Blackwell, W. Vale, R. Fellows, and R. Guillemin Purification, amino acid composition and N-terminus of the hypothalamic luteinizing hormone releasing factor (LRF) of ovine origin Biochem. Biophys. Res. Commun. 44 1971 205 210
3. G.M. Anderson, J.M. Connors, S.L. Hardy, M. Valent, and R.L. Goodman Oestradiol microimplants in the ventromedial preoptic area inhibit secretion of luteinizing hormone via dopamine neurones in anoestrous ewes J. Neuroendocrinol. 13 2001 1051 1058
4. R.D. Andrew, and F.E. Dudek Burst discharge in mammalian neuroendocrine cells involves an intrinsic regenerative mechanism Science 221 1983 1050 1052
5. B.L. Baker, W.C. Dermody, and J.R. Reel Distribution of gonadotropin-releasing hormone in the rat brain as observed with immunocytochemistry Endocrinology 97 1975 125 135
6. W. Beck, J.L. Hancke, and W. Wuttke Increased sensitivity of dopaminergic inhibition of luteinizing hormone release in immature and castrated female rats Endocrinology 102 1978 837 843
7. H.T. Bergen, J.F. Hejtmancik, and D.W. Pfaff Effects of gamma-aminobutyric acid receptor agonists and antagonist on LHRH-synthesizing neurons as detected by immunocytochemistry and in situ hybridization Exp. Brain Res. 87 1991 46 56
8. M. Bergendahl, J.N. Wiemann, D.K. Clifton, I. Huhtaniemi, and R.A. Steiner Short-term starvation decreases POMC mRNA but does not alter GnRH mRNA in the brain of adult male rats Neuroendocrinology 56 1992 913 920
9. J.J. Bonavera, A. Sahu, P.S. Kalra, and S.P. Kalra Evidence that nitric oxide may mediate the ovarian steroid-induced luteinizing hormone surge: involvement of excitatory amino acids Endocrinology 133 1993 2481 2487
10. R. Boukhliq, R.L. Goodman, S.J. Berriman, B. Adrian, and M.N. Lehman A subset of gonadotropin-releasing hormone neurons in the ovine medial basal hypothalamus is activated during increased pulsatile luteinizing hormone secretion Endocrinology 140 1999 5929 5936
11. D.I. Brown, V.T. Garyfallou, and H.F. Urbanski Photoperiodic modulation of GnRH mRNA in the male Syrian hamster Brain Res. Mol. Brain Res. 89 2001 119 125
12. J.M. Bruder, A.J. Spaulding, and M.E. Wierman Phorbol ester inhibition of rat gonadotropin-releasing hormone promoter activity: role of Fos and Jun in the repression of transcription Mol. Endocrinol. 10 1996 35 44
13. J.A. Butler, M. Sjoberg, and C.W. Coen Evidence for oestrogen receptor alpha-immunoreactivity in gonadotrophin-releasing hormone-expressing neurones J. Neuroendocrinol. 11 1999 331 335
14. G.A. Campbell, M. Kurcz, S. Marshall, and J. Meites Effects of starvation in rats on serum levels of follicle stimulating hormone, luteinizing hormone, thyrotropin, growth hormone and prolactin; response to LH-releasing hormone and thyrotropin-releasing hormone Endocrinology 100 1977 580 587
15. A. Caraty, C. Fabre-Nys, B. Delaleu, A. Locatelli, G. Bruneau, F.J. Karsch, and A. Herbison Evidence that the mediobasal hypothalamus is the primary site of action of estradiol in inducing the preovulatory gonadotropin releasing hormone surge in the ewe Endocrinology 139 1998 1752 1760
16. A. Caraty, and D.C. Skinner Dynamics of steroid regulation of GnRH secretion during the oestrus cycle of the ewe Ann. Endocrinol. 60 1999 68 78
17. J. Carolsfeld, J.F. Powell, M. Park, W.H. Fischer, A.G. Craig, J.P. Chang, J.E. Rivier, and N.M. Sherwood Primary structure and function of three gonadotropin-releasing hormones, including a novel form, from an ancient teleost, herring Endocrinology 141 2000 505 512
18. S. Ceccatelli Expression and plasticity of NO synthase in the neuroendocrine system Brain Res. Bull. 44 1997 533 538
19. U.R. Chandran, and D.B. DeFranco Regulation of gonadotropin-releasing hormone gene transcription Behav. Brain Res. 105 1999 29 36
20. H.M. Charlton, D.M.G. Halpin, C. Iddon, R. Rosie, G. Levy, I.F.W. McDowell, A. Megson, J.F. Morris, A. Bramwell, A. Speight, B.J. Ward, J. Broadhead, G. Davey-Smith, and G. Fink The effects of daily administration of single and multiple injections of gonadotropin-releasing hormone on pituitary and gonadal function in the hypogonadal (hpg) mouse Endocrinology 113 1983 535 544
21. S.A. Choudhury, R.M. Sharpe, and P.S. Brown The effect of pimozide, a dopamine antagonist, on pituitary gonadotrophic function in the rat J. Reprod. Fertil. 39 1974 275 283
22. I.J. Clarke Control of GnRH secretion J. Reprod. Fertil. Suppl. 34 1987 1 8
23. I.J. Clarke New concepts in gonadotrophin-releasing hormone action on the pituitary gland Semin. Reprod. Endocrinol. 5 1987 345 352
24. I.J. Clarke Gonadotrophin-releasing hormone secretion (GnRH) in anoestrous ewes and the induction of GnRH surges by oestrogen J. Endocrinol. 117 1988 355 360
25. I.J. Clarke Variable patterns of gonadotropin-releasing hormone secretion during the estrogen-induced luteinizing hormone surge in ovariectomized ewes Endocrinology 133 1993 1624 1632
26. I.J. Clarke Evidence that the switch from negative to positive feedback at the level of the pituitary gland is an important timing event for the onset of the preovulatory surge in LH in the ewe J. Endocrinol. 145 1995 271 282
27. I.J. Clarke The preovulatory LH surge. A case of a neuroendocrine switch Trends Endocrinol. Metab. 6 1995 241 247
28. I.J. Clarke The hypothalamo-pituitary axis S.G. Hillier H.C. Kitchener J.P. Neilsen Scientific Essentials of Reproductive Medicine 1996 W.B. Saunders Co. Ltd. UK 120 132
29. I.J. Clarke Two decades of measuring GnRH secretion Reprod. Suppl. 59 2002 1 13
30. I.J. Clarke, and J.T. Cummins The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes Endocrinology 111 1982 1737 1739
31. I.J. Clarke, and J.T. Cummins Direct pituitary effects of estrogen and progesterone on gonadotropin secretion in the ovariectomized ewe Neuroendocrinology 39 1984 267 274
32. I.J. Clarke, J.T. Cummins, J.K. Findlay, K.J. Burman, and B.W. Doughton Effects on plasma luteinizing hormone and follicle-stimulating hormone of varying the frequency and amplitude of gonadotropin-releasing hormone pulses in ovariectomized ewes with hypothalamo-pituitary disconnection Neuroendocrinology 39 1984 214 221
33. I.J. Clarke, J.K. Findlay, J.T. Cummins, and W.J. Ewens Effects of ovine follicular fluid on plasma LH and FSH secretion in ovariectomized ewes to indicate the site of action of inhibin J. Reprod. Fertil. 77 1986 575 585
34. I.J. Clarke, S. Pompolo, C.J. Scott, J.A. Rawson, D. Caddy, A.E. Jakubowska, and A.M. Pereira Cells of the arcuate nucleus and ventromedial nucleus of the ovariectomized ewe that respond to oestrogen: a study using Fos immunohistochemistry J. Neuroendocrinol. 13 2001 934 941
35. I.J. Clarke, G.B. Thomas, B. Yao, and J.T. Cummins GnRH secretion throughout the ovine estrous cycle Neuroendocrinology 46 1987 82 88
36. J.A. Clemens, F.C. Tinsley, and R.W. Fuller Evidence for a dopaminergic component in the series of neural events that lead to the pro-oestrous surge of LH Acta Endocrinol. (Copenh.) 85 1977 18 24
37. N. Debus, K.M. Breen, G.K. Barrell, H.J. Billings, M. Brown, E.A. Young, and F.J. Karsch Does cortisol mediate endotoxin-induced inhibition of pulsatile luteinizing hormone and gonadotropin-releasing hormone secretion? Endocrinology 143 2002 3748 3758
38. W.L. Dees, R.K. Dearth, R.N. Hooper, S.P. Brinsko, J.E. Romano, H. Rahe, W.H. Yu, and S.M. McCann Lamprey gonadotropin-releasing hormone-III selectively releases follicle stimulating hormone in the bovine Domest. Anim. Endocrinol. 20 2001 279 288
39. V.S. Densmore, and H.F. Urbanski Relative effect of gonadotropin- releasing hormone (GnRH)-I and GnRH-II on gonadotropin release J. Clin. Endocrinol. Metab. 88 2003 2126 2134
40. L.V. DePaolo, and C.A. Barraclough Dose dependent effects of progesterone on the facilitation and inhibition of spontaneous gonadotropin surges in estrogen treated ovariectomized rats Biol. Reprod. 21 1979 1015 1023
41. K.M. Dhandapani, and D.W. Brann The role of glutamate and nitric oxide in the reproductive neuroendocrine system Biochem. Cell Biol. 78 2000 165 179
42. H. Dhillon, A.M. Dunn, E. Esquivel, D.L. Hamernik, and M.E. Wise The estradiol-induced luteinizing hormone surge in the ewe is not associated with increased gonadotropin-releasing hormone messenger ribonucleic acid levels Biol. Reprod. 57 1997 107 111
43. S.V. Drouva, and R.V. Gallo Further evidence for inhibition of episodic luteinizing hormone release in ovariectomized rats by stimulation of dopamine receptors Endocrinology 100 1977 792 798
44. C.M. Dutlow, J. Rachman, T.W. Jacobs, and R.P. Millar Prepubertal increases in gonadotropin-releasing hormone mRNA, gonadotropin-releasing hormone precursor, and subsequent maturation of precursor processing in male rats J. Clin. Invest. 90 1992 2496 2501
45. M. El Majdoubi, A. Sahu, and T.M. Plant Changes in hypothalamic gene expression associated with the arrest of pulsatile gonadotropin-releasing hormone release during infancy in the agonadal male rhesus monkey (Macaca mulatta) Endocrinology 141 2000 3273 3277
46. S.A. Eraly, and P.L. Mellon Regulation of gonadotropin-releasing hormone transcription by protein kinase C is mediated by evolutionarily conserved promoter-proximal elements Mol. Endocrinol. 9 1995 848 859
47. N.P. Evans, G.E. Dahl, B.H. Glover, and F.J. Karsch Central regulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion by estrodiol during the period leading up to the preovulatory GnRH surge in the ewe Endocrinology 134 1994 1806 1811
48. N.P. Evans, J.R. McNeilly, and R. Webb Alterations in endogenous gonadotropin secretion and pituitary responsiveness to gonadotropin-releasing hormone in adult ewes, following indirect selection in prepubertal male lambs Biol. Reprod. 51 1994 913 919
49. O. Eyigor, and L. Jennes Kainate receptor subunit-positive gonadotropin-releasing hormone neurons express c-Fos during the steroid-induced luteinizing hormone surge in the female rat Endocrinology 141 2000 779 786
50. E. Falkenstein, and M. Wehling Nongenomically initiated steroid actions Eur. J. Clin. Invest. 3 30 Suppl. 2000 51 54
51. R.D. Fernald, and R.B. White Gonadotropin-releasing hormone genes: phylogeny, structure, and functions Front. Neuroendocrinol. 20 1999 224 240
52. H. Ford, and F.J. Ebling Glutamatergic regulation of gonadotropin releasing hormone mRNA levels during development in the mouse J. Neuroendocrinol. 12 2000 1027 1033
53. E.D. Gestrin, R.B. White, and R.D. Fernald Second form of gonadotropin-releasing hormone in mouse: immunocytochemistry reveals hippocampal and periventricular distribution FEBS Lett. 448 1999 289 291
54. P.C. Goldsmith, K.K. Thind, A.D. Perera, and T.M. Plant Glutamate-immunoreactive neurons and their gonadotropin-releasing hormone neuronal interactions in the monkey hypothalamus Endocrinology 134 1994 858 868
55. R.L. Goodman, S.J. Legan, K.D. Ryan, D.L. Foster, and F.J. Karsch Importance of variations in behavioural and feedback actions of oestradiol to the control of seasonal breeding in the ewe J. Endocrinol. 89 1981 229 240
56. A.C. Gore Gonadotropin-releasing hormone neurons, NMDA receptors, and their regulation by steroid hormones across the reproductive life cycle Brain Res. Brain Res. Rev. 37 2001 235 248
57. A.C. Gore GnRH: The Master Molecule of Reproduction 2002 Kuewer Academic Publishers Boston, USA
58. A.C. Gore Gonadotropin-releasing hormone (GnRH) neurons: gene expression and neuroanatomical studies Prog. Brain Res. 141 2002 193 208
59. A.C. Gore, T. Oung, S. Yung, R.A. Flagg, and M.J. Woller Neuroendocrine mechanisms for reproductive senescence in the female rat: gonadotropin-releasing hormone neurons Endocrine 13 2000 315 323
60. A.C. Gore, and J.L. Roberts Regulation of gonadotropin-releasing hormone gene expression by the excitatory amino acids kainic acid and N-methyl-d,l-aspartate in the male rat Endocrinology 134 1994 2026 2031
61. A.C. Gore, and J.L. Roberts Regulation of gonadotropin-releasing hormone gene expression in the rat during the luteinizing hormone surge Endocrinology 136 1995 889 896
62. A.C. Gore, and J.L. Roberts Regulation of gonadotropin-releasing hormone gene expression in vivo and in vitro Front. Neuroendocrinol. 18 1997 209 245
63. A.C. Gore, J.L. Roberts, and M.J. Gibson Mechanisms for the regulation of gonadotropin-releasing hormone gene expression in the developing mouse Endocrinology 140 1999 2280 2287
64. A.C. Gore, and E. Terasawa Neural circuits regulating pulsatile luteinizing hormone release in the female guinea-pig: opioid, adrenergic and serotonergic interactions J. Neuroendocrinol. 13 2001 239 248
65. D.R. Grattan, M.S. Rocca, C.A. Sagrillo, M.M. McCarthy, and M. Selmanoff Antiandrogen microimplants into the rostral medial preoptic area decrease gamma-aminobutyric acidergic neuronal activity and increase luteinizing hormone secretion in the intact male rat Endocrinology 137 1996 4167 4173
66. D. Grove-Strawser, S.A. Sower, P.M. Ronsheim, J.B. Connolly, C.G. Bourn, and B.S. Rubin Guinea pig GnRH: localization and physiological activity reveal that it, not mammalian GnRH, is the major neuroendocrine form in guinea pigs Endocrinology 143 2002 1602 1612
67. D.A. Gruenewald, and A.M. Matsumoto Reduced gonadotropin-releasing hormone gene expression with fasting in the male rat brain Endocrinology 132 1993 480 482
68. D.A. Gruenewald, M.A. Naai, B.T. Marck, and A.M. Matsumoto Age-related decrease in hypothalamic gonadotropin-releasing hormone (GnRH) gene expression, but not pituitary responsiveness to GnRH, in the male Brown Norway rat J. Androl. 21 2000 72 84
69. G.W. Harris Neural Control of the Pituitary Gland 1955 Arnold London, UK
70. T.G. Harris, J.E. Robinson, N.P. Evans, D.C. Skinner, and A.E. Herbison Gonadotropin-releasing hormone messenger ribonucleic acid expression changes before the onset of the estradiol-induced luteinizing hormone surge in the ewe Endocrinology 139 1998 57 64
71. J.R. He, J. Molnar, and C.A. Barraclough Morphine amplifies norepinephrine (NE)-induced LH release but blocks NE-stimulated increases in LHRH mRNA levels: comparison of responses obtained in ovariectomized, estrogen-treated normal and androgen-sterilized rats Brain Res. 20 1993 71 78
72. B.A. Henry Links between the appetite regulating systems and the neuroendocrine hypothalamus: lessons from the sheep J. Neuroendocrinol. 15 2003 697 709
73. B.A. Henry, J.W. Goding, A.J. Tilbrook, F.R. Dunshea, and I.J. Clarke Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in long-term food-restricted sheep, but increases growth hormone irrespective of bodyweight J. Endocrinol. 168 2001 67 77
74. A.E. Herbison Noradrenergic regulation of cyclic GnRH secretion Rev. Reprod. 2 1997 1 6
75. A.E. Herbison Multimodal influence of estrogen upon gonadotropin- releasing hormone neurons Endocr. Rev. 19 1998 302 330
76. A.E. Herbison, and J.R. Pape New evidence for estrogen receptors in gonadotropin-releasing hormone neurons Front Neuroendocrinol. 22 2001 292 308
77. A.E. Herbison, D.C. Skinner, J.E. Robinson, and I.S. King Androgen receptor-immunoreactive cells in the ram hypothalamus: distribution and co-localization patterns with gonadotropin-releasing hormone, somatostatin and tyrosine hydroxylase Neuroendocrinology 63 1996 120 131
78. S.M. Hileman, D.E. Kuehl, and G.L. Jackson Photoperiod affects the ability of testosterone to alter proopiomelanocortin mRNA, but not luteinizing hormone-releasing hormone mRNA, levels in male sheep J. Neuroendocrinol. 10 1998 587 592
79. S.M. Hileman, L.S. Lubbers, S.L. Petersen, D.E. Kuehl, C.J. Scott, and G.L. Jackson Influence of testosterone on LHRH release, LHRH mRNA and proopiomelanocortin mRNA in male sheep J. Neuroendocrinol. 8 1996 113 121
80. E. Hrabovszky, P.J. Shughrue, I. Merchenthaler, T. Hajszan, C.D. Carpenter, Z. Liposits, and S.L. Petersen Detection of estrogen receptor-beta messenger ribonucleic acid and 125I-estrogen binding sites in luteinizing hormone-releasing hormone neurons of the rat brain Endocrinology 141 2000 3506 3509
81. H.H. Huang, R.W. Steger, J.F. Bruni, and J. Meites Patterns of sex steroid and gonadotropin secretion in aging female rats Endocrinology 103 1978 1855 1859
82. H. I'Anson, J.M. Manning, C.G. Herbosa, J. Pelt, C.R. Friedman, R.I. Wood, D.C. Bucholtz, and D.L. Foster Central inhibition of gonadotropin- releasing hormone secretion in the growth-restricted hypogonadotropic female sheep Endocrinology 141 2000 520 527
83. M. Jakubowski, M. Blum, and J.L. Roberts Postnatal development of gonadotropin-releasing hormone and cyclophilin gene expression in the female and male rat brain Endocrinology 128 1991 2702 2708
84. M. Jakubowski, and J.L. Roberts Processing of gonadotropin-releasing hormone gene transcripts in the rat brain J. Biol. Chem. 269 1994 4078 4083
85. M. Jimenez-Linan, B.S. Rubin, and J.C. King Examination of guinea pig luteinizing hormone-releasing hormone gene reveals a unique decapeptide and existence of two transcripts in the brain Endocrinology 138 1997 4123 4130
86. S.J. Judd, J.S. Rakoff, and S.S. Yen Inhibition of gonadotropin and prolactin release by dopamine: effect of endogenous estradiol levels J. Clin. Endocrinol. Metab. 47 1978 494 498
87. S.P. Kalra Tissue levels of luteinizing hormone-releasing hormone in the preoptic area and hypothalamus, and serum concentrations of gonadotropins following anterior hypothalamic deafferentation and estrogen treatment of the female rat Endocrinology 99 1976 101 107
88. S.P. Kalra Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-releasing hormone discharge Endocr. Rev. 14 1993 507 538
89. S.P. Kalra, and P.S. Kalra Neural regulation of luteinizing hormone secretion in the rat Endocr. Rev. 4 1983 311 350
90. S.P. Kalra, and P.S. Kalra Do testosterone and estradiol-17B enforce inhibition or stimulation of luteinizing hormone-releasing hormone secretion Biol. Reprod. 41 1989 559 570
91. S.H. Kang, J.Y. Seong, S. Cho, H. Cho, and K. Kim Acute increase of GABAergic neurotransmission exerts a stimulatory effect on GnRH gene expression in the preoptic/anterior hypothalamic area of ovariectomized, estrogen- and progesterone-treated adult female rats Neuroendocrinology 61 1995 486 492
92. S.S. Kang, G.H. Son, J.Y. Seong, D. Choi, H.B. Kwon, C.C. Lee, and K. Kim Noradrenergic neurotoxin suppresses gonadotropin-releasing hormone (GnRH) and GnRH receptor gene expression in ovariectomized and steroid-treated rats J. Neuroendocrinol. 10 1998 911 918
93. F.J. Karsch, G.E. Dahl, N.P. Evans, J.M. Manning, K.P. Mayfield, S.M. Moenter, and D.L. Foster Seasonal changes in gonadotropin-releasing hormone secretion in the ewe: alteration in response to the negative feedback action of estradiol Biol. Reprod. 49 1993 1377 1383
94. J.Z. Kasa-Vubu, G.E. Dahl, N.P. Evans, L.A. Thrun, S.M. Moenter, V. Padmanabhan, and F.J. Karsch Progesterone blocks the estradiol-induced gonadotropin discharge in the ewe by inhibiting the surge of gonadotropin-releasing hormone Endocrinology 131 1992 208 212
95. K. Kawamoto, S. Tanaka, M. Kawano, T. Hayashi, and K. Tsuchiya Effects of photoperiod and ambient temperature on the gonadotropin-releasing hormone neuronal system in the gray hamster, Tscherskia triton Neuroendocrinology 72 2000 284 292
96. C.G. Kelley, M.L. Givens, N. Rave-Harel, S.B. Nelson, S. Anderson, and P.L. Mellon Neuron-restricted expression of the rat gonadotropin-releasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elements Mol. Endocrinol. 16 2002 2413 2425
97. C.G. Kelley, G. Lavorgna, M.E. Clark, E. Boncinelli, and P.L. Mellon The Otx2 homeoprotein regulates expression from the gonadotropin-releasing hormone proximal promoter Mol. Endocrinol. 14 2000 1246 1256
98. M.J. Kelly, J. Garrett, M.A. Bosch, C.E. Roselli, J. Douglass, J.P. Adelman, and O.K. Ronnekleiv Effects of ovariectomy on GnRH mRNA, proGnRH and GnRH levels in the preoptic hypothalamus of the female rat Neuroendocrinology 49 1989 88 97
99. J.K. Kepa, B.M. Jacobsen, E.A. Boen, P. Prendergast, D.P. Edwards, G. Takimoto, and M.E. Wierman Direct binding of progesterone receptor to nonconsensus DNA sequences represses rat GnRH Mol Cell Endocrinol. 117 1996 27 39
100. K. Kim, B.J. Lee, B.N. Cho, S.S. Kang, W.S. Choi, S.D. Park, C.C. Lee, W.K. Cho, and W. Wuttke Blockade of noradrenergic neurotransmission with diethyldithiocarbamic acid decreases the mRNA level of gonadotropin-releasing hormone in the hypothalamus of ovariectomized, steroid-treated prepubertal rats Neuroendocrinology 59 1994 539 544
101. K. Kim, B.J. Lee, Y. Park, and W.K. Cho Progesterone increases messenger ribonucleic acid (mRNA) encoding luteinizing hormone releasing hormone (LHRH) level in the hypothalamus of ovariectomized estradiol-primed prepubertal rats. Brain Res. 6 1989 151 158
102. J.C. King, J.A. Parsons, S.L. Erlandsen, and T.H. Williams Luteinizing hormone-releasing hormone (LH-RH) pathway of the rat hypothalamus revealed by the unlabeled antibody peroxidase-antiperoxidase method Cell Tissue Res. 153 1974 211 217
103. R.M. Kobayashi, K.H. Lu, R.Y. Moore, and S.S. Yen Regional distribution of hypothalamic luteinizing hormone-releasing hormone in proestrous rats: effects of ovariectomy and estrogen replacement Endocrinology 102 1978 98 105
104. S.J. Krajewski, T.W. Abel, M.L. Voytko, and N.E. Rance Ovarian steroids differentially modulate the gene expression of gonadotropin-releasing hormone neuronal subtypes in the ovariectomized cynomolgus monkey J. Clin. Endocrinol. Metab. 88 2003 655 662
105. J.H. Krege, J.B. Hodgin, J.F. Couse, E. Enmark, M. Warner, J.F. Mahler, M. Sar, K.S. Korach, J.A. Gustafsson, and O. Smithies Generation and reproductive phenotypes of mice lacking estrogen receptor beta Proc. Natl. Acad. Sci. U.S.A. 95 1998 15677 15682
106. L.J. Kriegsfeld, N.J. Ranalli, M.A. Bober, and R.J. Nelson Photoperiod and temperature interact to affect the GnRH neuronal system of male prairie voles (Microtus ochrogaster) J. Biol. Rhythms 15 2000 306 316
107. L.J. Kriegsfeld, N.J. Ranalli, A.G. Trasy, and R.J. Nelson Food restriction affects the gonadotropin releasing hormone neuronal system of male prairie voles (Microtus ochrogaster) J. Neuroendocrin. 13 2001 791 798
108. A.H. Lagrange, O.K. Ronnekleiv, and M.J. Kelly Estradiol-17 beta and mu-opioid peptides rapidly hyperpolarize GnRH neurons: a cellular mechanism of negative feedback? Endocrinology 136 1995 2341 2344
109. V.S. Latimer, S.M. Rodrigues, V.T. Garyfallou, S.G. Kohama, R.B. White, R.D. Fernald, and H.F. Urbanski Two molecular forms of gonadotropin-releasing hormone (GnRH-I and GnRH-II) are expressed by two separate populations of cells in the rhesus macaque hypothalamus. Brain Res. Mol. Brain Res. 75 2000 287 292
110. M.A. Lawson, D.B. Whyte, and P.L. Mellon GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene Mol. Cell Biol. 16 1996 3596 3605
111. S. Le Corre, and P. Chemineau Control of photoperiodic inhibition of luteinizing hormone secretion by dopaminergic and serotonergic systems in ovariectomized Ile-de-France ewes supplemented with oestradiol J. Reprod. Fertil. 97 1993 367 373
112. S.J. Legan, G.A. Coon, and F.J. Karsch Role of estrogen as initiator of daily LH surges in the ovariectomized rat Endocrinology 96 1975 50 56
113. M.N. Lehman, L.M. Coolen, R.L. Goodman, C. Viguie, H.J. Billings, and F.J. Karsch Seasonal plasticity in the brain: the use of large animal models for neuranatomical research Reproduction S59 2002 149 165
114. M.N. Lehman, and F.J. Karsch Do gonadotropin-releasing hormone, tyrosine hydroxylase-, and b-endorphin-immunoreactive neurons contain oestrogen receptors? A double-label immunocytochemical study in the Suffolk ewe Endocrinology 133 1993 887 895
115. M.N. Lehman, J.E. Robinson, F.J. Karsch, and A.J. Silverman Immunocytochemical localization of luteinizing hormone-releasing hormone (LHRH) pathways in the sheep brain during anestrus and the mid-luteal phase of the estrous cycle J. Comp. Neurol. 244 1986 19 35
116. S. Leonhardt, J.Y. Seong, K.J. Kim, Y. Thorun, W. Wuttke, and H. Jarry Activation of central GABAA - but not of GABAB - receptors rapidly reduces pituitary LH release and GnRH gene expression in the preoptic anterior hypothalamic area of ovariectomized rats Neuroendocrinology 61 1995 655 662
117. S. Leonhardt, M. Shahab, H. Luft, W. Wuttke, and H. Jarry Reduction of luteinzing hormone secretion induced by long-term feed restriction in male rats is associated with increased expression of GABA-synthesizing enzymes without alterations of GnRH gene expression J. Neuroendocrin. 11 1999 613 619
118. J. Li, H. Francis, and I.J. Clarke Effects of bovine follicular fluid on pulsatile secretion of gonadotrophin-releasing hormone and gonadotrophins in ovariectomized ewes J. Neuroendocrin. 1 1989 61 64
119. S. Li, E. Garcia de Yebenes, and G. Pelletier Effects of dehydroepiandrosterone (DHEA) on GnRH gene expression in the rat brain as studied by in situ hybridization Peptides 16 1995 425 430
120. S. Li, M. Hong, A. Fournier, S. St Pierre, and G. Pelletier Role of neuropeptide Y in the regulation of gonadotropin-releasing hormone gene expression in the rat preoptic area Brain Res. Mol. Brain Res. 26 1994 69 73
121. S. Li, and G. Pelletier Dopamine regulation of gonadotropin-releasing hormone (GnRH) gene expression in the female rat brain Neurosci. Lett. 146 1992 207 210
122. S. Li, and G. Pelletier Role of dopamine in the regulation of gonadotropin-releasing hormone in the male rat brain as studied by in situ hybridization Endocrinology 131 1992 395 399
123. S. Li, and G. Pelletier Chronic administration of muscimol and pentobarbital decreases gonadotropin-releasing hormone mRNA levels in the male rat hypothalamus determined by quantitative in situ hybridization Neuroendocrinology 58 1993 136 139
124. S. Li, and G. Pelletier Opioid regulation of gonadotropin-releasing hormone gene expression in the male rat brain as studied by in situ hybridization Neuroreport 4 1993 331 333
125. S. Li, and G. Pelletier Inhibitory effect of the potential endogenous benzodiazepine receptor ligand, octadecaneuropeptide (ODN), on gonadotropin-releasing hormone gene expression in the male rat brain Neuroreport 6 1995 1354 1356
126. S. Li, and G. Pelletier Involvement of serotonin in the regulation of GnRH gene expression in the male rat brain Neuropeptides 29 1995 21 25
127. J.J. Liaw, and C.A. Barraclough N-methyl-d,l-aspartic acid differentially affects LH release and LHRH mRNA levels in estrogen-treated ovariectomized control and androgen-sterilized rats Brain Res. 17 1993 112 118
128. W. Lin, K. McKinney, L. Liu, S. Lakhlani, and L. Jennes Distribution of vesicular glutamate transporter-2 messenger ribonucleic Acid and protein in the septum-hypothalamus of the rat Endocrinology 144 2003 662 670
129. X.W. Lin, C.J. Otto, and R.E. Peter Evolution of neuroendocrine peptide systems: gonadotropin-releasing hormone and somatostatin Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol. 119 1998 375 388
130. G.A. Lincoln Neuroendocrine regulation of seasonal gonadotrophin and prolactin rhythms: lessons from the Soay ram model Reprod. Suppl. 59 2002 131 147
131. G.A. Lincoln, and H.M. Fraser Compensatory response of the luteinizing-hormone(LH)-releasing hormone (LHRH)/LH pulse generator after administration of a potent LHRH antagonist in the ram Endocrinology 120 1987 2245 2250
132. K.H. Lu, H.H. Huang, H.T. Chen, M. Kurcz, R. Mioduskewski, and J. Meites Positive feedback by estrogen and progesterone on LH release in old and young rats Proc. Soc. Exp. Biol. Med. 154 1977 82 85
133. D.B. Lubahn, J.S. Moyer, T.S. Golding, J.F. Couse, K.S. Korach, and O. Smithies Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene Proc. Natl. Acad. Sci. U.S.A. 90 1993 11162 11166
134. K.F. Malik, A.J. Silverman, and J.I. Morrell Gonadotropin-releasing hormone mRNA in the rat: distribution and neuronal content over the estrous cycle and after castration of males Anat. Rec. 231 1991 457 466
135. P.E. Marshall, and P.C. Goldsmith Neuroregulatory and neuroendocrine GnRH pathways in the hypothalamus and forebrain of the baboon Brain Res. 193 1980 353 372
136. A.J. Mason, J.S. Hayflick, R.T. Zoeller, W.S. Young III, H.S. Phillips, K. Nikolics, and P.H. Seeburg A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse Science 234 1986 1366 1371
137. H. Matsuo, Y. Baba, R.M. Nair, A. Arimura, and A.V. Schally Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence Biochem. Biophys. Res Commun. 43 1971 1334 1339
138. J.R. McDermott, A.I. Smith, J.A. Biggins, J.A. Hardy, P.R. Dodd, and J.A. Edwardson Degradation of luteinizing hormone-releasing hormone by serum and plasma in vitro Regul. Pept. 2 1981 69 79
139. T.M. McShane, S.L. Petersen, S. McCrone, and D.H. Keisler Influence of food restriction on neuropeptide-Y, proopiomelanocortin, and luteinizing hormone-releasing hormone gene expression in sheep hypothalami Biol. Reprod. 49 1993 831 839
140. P.L. Mellon, J.J. Windle, P.C. Goldsmith, C.A. Padula, J.L. Roberts, and R.I. Weiner Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis Neuron 5 1990 1 10
141. S.L. Meyer, and R.L. Goodman Neurotransmitters involved in mediating the steroid-dependent suppression of pulsatile luteinizing hormone secretion in anestrous ewes: effects of receptor antagonists Endocrinology 116 1985 2054 2061
142. J.R. Millam, C.B. Craig-Veit, T.E. Adams, and B.M. Adams Avian gonadotropin-releasing hormones I and II in brain and other tissues in turkey hens Comp. Biochem. Physiol. A 94 1989 771 776
143. B.H. Miller, and A.C. Gore N-methyl-d-aspartate receptor subunit expression in GnRH neurons changes during reproductive senescence in the female rat Endocrinology 143 2002 3568 3574
144. K. Miyamoto, Y. Hasegawa, T. Minegishi, M. Nomura, Y. Takahashi, M. Igarashi, K. Kangawa, and H. Matsuo Isolation and characterization of chicken hypothalamic luteinizing hormone-releasing hormone Biochem. Biophys. Res. Commun. 107 1982 820 827
145. S.M. Moenter, A. Caraty, A. Locatelli, and F.J. Karsch Pattern of gonadotropin-releasing hormone (GnRH) secretion leading up to ovulation in the ewe: existence of a preovulatory GnRH surge Endocrinology 129 1991 1175 1182
146. A.D. Montaner, J.M. Affanni, J.A. King, J.J. Bianchini, G. Tonarelli, and G.M. Somoza Differential distribution of gonadotropin-releasing hormone variants in the brain of Hydrochaeris hydrochaeris (Mammalia, Rodentia) Cell Mol. Neurobiol. 19 1999 635 651
147. S.B. Nelson, S.A. Eraly, and P.L. Mellon The GnRH promoter: target of transcription factors, hormones, and signaling pathways Mol. Cell. Endocrinol. 140 1998 151 155
148. C.S. Nunemaker, R.A. DeFazio, and S.M. Moenter Estradiol-sensitive afferents modulate long-term episodic firing patterns of GnRH neurons Endocrinology 143 2002 2284 2292
149. K. Okuzawa, M. Amano, M. Kobayashi, K. Aida, I. Hanyu, Y. Hasegawa, and K. Miyamoto Differences in salmon GnRH and chicken GnRH-II contents in discrete brain areas of male and female rainbow trout according to age and stage of maturity Gen. Comp. Endocrinol. 80 1990 116 126
150. E.N. Ottem, J.G. Godwin, and S.L. Petersen Glutamatergic signaling through the N-methyl-d-aspartate receptor directly activates medial subpopulations of luteinizing hormone-releasing hormone (LHRH) neurons, but does not appear to mediate the effects of estradiol on LHRH gene expression Endocrinology 143 2002 4837 4845
151. R.B. Page, and B.J. Dovey-Hartman Neurohemal contact in the internal zone of the rabbit median eminence J. Comp. Neurol. 226 1984 274 288
152. D.B. Parfitt, R.C. Thompson, H.N. Richardson, R.D. Romeo, and C.L. Sisk GnRH mRNA increases with puberty in the male Syrian hamster brain J. Neuroendocrinol. 11 1999 621 627
153. O.-K. Park, S. Gugneja, and K.E. Mayo Gonadotropin-releasing hormone gene expression during the rat estrous cycle: effects of pentobarbital and ovarian steroids Endocrinology 127 1990 365 372
154. S.L. Petersen, and C.A. Barraclough Suppression of spontaneous LH surges in estrogen-treated ovariectomized rats by microimplants of antiestrogens into the preoptic brain Brain Res. 484 1989 279 289
155. S.L. Petersen, E. Gardner, J. Adelman, and S. McCrone Examination of steroid-induced changes in LHRH gene transcription using 33P-and 35S-labeled probes specific for intron 2 Endocrinology 137 1996 234 239
156. S.L. Petersen, S. McCrone, M. Keller, and E. Gardner Rapid increase in LHRH mRNA levels following NMDA Endocrinology 129 1991 1679 1681
157. S.L. Petersen, S. McCrone, M. Keller, and S. Shores Effects of estrogen and progesterone on luteinizing hormone-releasing hormone messenger ribonucleic acid levels: consideration of temporal and neuroanatomical variables Endocrinology 136 1995 3604 3610
158. S.L. Petersen, S. McCrone, and S. Shores Localized changes in LHRH mRNA levels as cellular correlates of the positive feedback effects of estrogen on LHRH neurons Am. Zool. 33 1993 255 265
159. T.M. Plant, and M. Shahab Neuroendocrine mechanisms that delay and initiate puberty in higher primates Physiol. Behav. 77 2002 717 722
160. J. Polkowska, M.P. Dubois, and E. Domanski Immunocytochemistry of luteinizing hormone releasing hormone (LHRH) in the sheep hypothalamus during variuos reproductive stages: correlation with the gonadotropic hormones of the pituitary Cell Tissue Res. 208 1980 327 341
161. S. Pompolo, A. Pereira, T. Kaneko, and I.J. Clarke Seasonal changes in the inputs to gonadotropin-releasing hormone neurons in the ewe brain; an assessment by conventional and confocal microscopy J. Neuroendocrinol. 15 2003 538 545
162. S. Pompolo, A. Pereira, C.J. Scott, F. Fujiyama, and I.J. Clarke Evidence for estrogenic regulation of gonadotropin-releasing hormone neurons by glutamatergic neurons in the ewe brain: an immunohistochemical study using an antibody against vesicular glutamate transporter-2 J. Comp. Neurol. 465 2003 136 144
163. S. Pompolo, J.A. Rawson, and I.J. Clarke Projections from the arcuate/ventromedial region of the hypothalamus to the preoptic area and bed nucleus of stria terminalis in the brain of the ewe; lack of direct input to gonadotropin-releasing hormone neurons Brain Res. 904 2001 1 12
164. T. Porkka-Heiskanen, N. Khoshaba, K. Scarbrough, J.H. Urban, M.H. Vitaterna, J.E. Levine, F.W. Turek, and T.H. Horton Rapid photoperiod-induced increase in detectable GnRH mRNA-containing cells in Siberian hamster Am. J. Physiol. 273 1997 R2032 R2039
165. T. Porkka-Heiskanen, J.H. Urban, F.W. Turek, and J.E. Levine Gene expression in a subpopulation of luteinizing hormone-releasing hormone (LHRH) neurons prior to the preovulatory gonadotropin surge J. Neurosci. 14 1994 5548 5558
166. J.C. Porter, and K.R. Smith Collection of hypophysial stalk blood in rats Endocrinology 81 1967 1182 1185
167. S. Radovick, C.M. Ticknor, Y. Nakayama, A.C. Notides, A. Rahman, B.D. Weintraub, G.B. Cutler Jr., and F.E. Wondisford Evidence for direct estrogen regulation of the human gonadotropin-releasing hormone gene J. Clin. Invest. 88 1991 1649 1655
168. N.E. Rance, and S.V. Uswandi Gonadotropin-releasing hormone gene expression is increased in the medial basal hypothalamus of postmenopausal women J. Clin. Endocrinol. Metab. 81 1996 3540 3546
169. J.A. Rawson, C.J. Scott, A.M. Pereira, A. Jakubowiak, and I.J. Clarke Noradrenergic projections from the A1 field to the preoptic area in the brain of ewe and fos responses to oestrogen in th A1 cells J. Neuroendocrinol. 13 2001 129 138
170. M. Razandi, A. Pedram, S.T. Park, and E.R. Levin Proximal events in signaling by plasma membrane estrogen receptors J. Biol. Chem. 278 2003 2701 2712
171. J.L. Roberts, C.M. Dutlow, M. Jakubowski, M. Blum, and R.P. Millar Estradiol stimulates preoptic area-anterior hypothalamic proGnRH-GAP gene expression in ovariectomized rats Brain Res. 6 1989 127 134
172. J.E. Robinson, A.E. Healey, T.G. Harris, E.A. Messent, D.C. Skinner, J.A. Taylor, and N.P. Evans The negative feedback action of progesterone on luteinizing hormone release is not associated with changes in GnRH mRNA expression in the ewe J. Neuroendocrinol. 12 2000 121 129
173. E. Ronchi, L.C. Krey, and D.W. Pfaff Steady-state analysis of hypothalamic GnRH mRNA levels in male Syrian hamsters: influences of photoperiod and androgen Neuroendocrinology 55 1992 146 155
174. R. Rosie, E. Thomson, and G. Fink Oestrogen positive feedback stimulates the synthesis of LHRH mRNA in neurones of the rostral diencephalon of the rat J. Endocrinol. 124 1990 285 289
175. D. Roy, N.L. Angelini, and D.D. Belsham Estrogen directly respresses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha)- and ERbeta-expressing GT1-7 GnRH neurons Endocrinology 140 1999 5045 5053
176. B.S. Rubin, C.E. Lee, M. Ohtomo, and J.C. King Luteinizing hormone-releasing hormone gene expression differs in young and middle-aged females on the day of a steroid-induced LH surge Brain. Res. 770 1997 267 276
177. C.A. Sagrillo, D.R. Grattan, M.M. McCarthy, and M. Selmanoff Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors Behav. Genet. 26 1996 241 277
178. D.K. Sarkar, S.A. Chiappa, G. Fink, and N.M. Sherwood Gonadotropin-releasing hormone surge in pro-oestrous rats Nature 264 1976 461 463
179. D.K. Sarkar, and G. Fink Gonadotropin-releasing hormone surge: possible modulation through postsynaptic alpha-adrenoreceptors and two pharmacologically distinct dopamine receptors Endocrinology 108 1981 862 867
180. R.J. Scaramuzzi, S.A. Tillson, I.H. Thorneycroft, and B.V. Caldwell Action of exogenous progesterone and estrogen on behavioral estrus and luteinizing hormone levels in the ovariectomized ewe Endocrinology 88 1971 1184 1189
181. M. Schwanzel-Fukuda, D. Bick, and D.W. Pfaff Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome Brain Res. Mol. Brain. Res. 6 1989 311 326
182. M. Schwanzel-Fukuda, and D.W. Pfaff Origin of luteinizing hormone-releasing hormone neurons Nature 338 1989 161 164
183. C.J. Scott, J.A. Rawson, A.M. Pereira, and I.J. Clarke Oestrogen receptors in the brainstem of the female sheep: relationship to noradrenergic cells and cells projecting to the medial preoptic area J. Neuroendocrinol. 11 1999 745 755
184. P.H. Seeburg, and J.P. Adelman Characterization of cDNA for precursor of human luteinizing hormone releasing hormone Nature 311 1984 666 668
185. M. Selmanoff, C. Shu, S.L. Petersen, C.A. Barraclough, and R.T. Zoeller Single cell levels of hypothalamic messenger ribonucleic acid encoding luteinizing hormone-releasing hormone in intact, castrated, and hyperprolactinemic male rats Endocrinology 128 1991 459 466
186. J.Y. Seong, Y.K. Lee, C.C. Lee, and K. Kim NMDA receptor antagonist decreases the progesterone-induced increase in GnRH gene expression in the rat hypothalamus Neuroendocrinology 58 1993 234 239
187. J.Y. Seong, S. Park, and K. Kim Enhanced splicing of the first intron from the gonadotropin-releasing hormone (GnRH) primary transcript is a prerequisite for mature GnRH messenger RNA: presence of GnRH neuron-specific splicing factors Mol. Endocrinol. 13 1999 1882 1895
188. N. Sherwood, L. Eiden, M. Brownstein, J. Spiess, J. Rivier, and W. Vale Characterization of a teleost gonadotropin-releasing hormone Proc. Natl. Acad. Sci. U.S.A. 80 1983 2794 2798
189. B.D. Shivers, R.E. Harlan, J.I. Morrell, and D.W. Pfaff Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones Nature 304 1983 345 347
190. C.L. Sisk, H.N. Richardson, P.E. Chappell, and J.E. Levine In vivo gonadotropin-releasing hormone secretion in female rats during peripubertal development and on proestrus Endocrinology 142 2001 2929 2936
191. D.C. Skinner, A. Caraty, and R. Allingham Unmasking the progesterone receptor in the preoptic area and hypothalamus of the ewe: no colocalization with gonadotropin-releasing neurons Endocrinology 142 2001 573 579
192. G.H. Son, H. Jung, J.Y. Seong, Y. Choe, D. Geum, and K. Kim Excision of the first intron from the gonadotropin-releasing hormone (GnRH) transcript serves as a key regulatory step for GnRH biosynthesis J. Biol. Chem. 278 2003 18037 18044
193. D.P. Spratt, and A.E. Herbison Regulation of preoptic area gonadotrophin-releasing hormone (GnRH) mRNA expression by gonadal steroids in the long-term gonadectomized male rat Brain Res. Mol. Brain Res. 47 1997 125 133
194. M. Suzuki, M. Nishihara, and M. Takahashi Hypothalamic gonadotropin-releasing hormone gene expression during rat estrous cycle Endocrin. J. 42 1995 789 796
195. J.L. Temple, R.P. Millar, and E.F. Rissman An evolutionarily conserved form of gonadotropin-releasing hormone coordinates energy and reproductive behavior Endocrinology 144 2003 13 19
196. N.R. Thanky, R. Slater, and A.E. Herbison Sex differences in estrogen-dependent transcription of gonadotropin-releasing hormone (GnRH) gene revealed in GnRH transgenic mice Endocrinology 144 2003 3351 3358
197. J.C. Thiery, P. Chemineau, X. Hernandez, M. Migaud, and B. Malpaux Neuroendocrine interactions and seasonality Domest. Anim. Endocrinol. 23 2002 87 100
198. G.B. Thomas, J.E. Mercer, T. Karalis, A. Rao, J.T. Cummins, and I.J. Clarke Effect of restricted feeding on the concentrations of growth hormone (GH), gonadotropins, and prolactin (PRL) in plasma, and on the amounts of messenger ribonucleic acid for GH, gonadotropin subunits, and PRL in the pituitary glands of adult ovariectomized ewes Endocrinology 126 1990 1361 1367
199. A.J. Tilbrook, and I.J. Clarke Evidence that dopaminergic neurons are not involved in the negative feedback effect of testosterone on luteinizing hormone in rams in the non-breeding season J. Neuroendocrinol. 4 1992 365 374
200. A.J. Tilbrook, D.M. de Kretser, and I.J. Clarke Human recombinant inhibin A suppresses plasma follicle stimulating hormone to intact levels but has no effect on luteinizing hormone in castrated rams Biol. Reprod. 49 1993 779 788
201. A.J. Tilbrook, D.M. de Kretser, and I.J. Clarke Seasonal changes in the negative feedback regulation of the secretion of the gonadotrophins by testosterone and inhibin in rams J. Endocrinol. 160 1999 155 166
202. A.J. Tilbrook, D.M. de Kretser, and I.J. Clarke Influence of the degree of stimulation of the pituitary by gonadotropin-releasing hormone on the action of inhibin and testosterone to suppress the secretion of the gonadotropins in rams Biol. Reprod. 64 2001 473 481
203. A.J. Tilbrook, D.M. de Kretser, J.T. Cummins, and I.J. Clarke The negative feedback effects of testicular steroids are predominantly at the hypothalamus in the ram Endocrinology 129 1991 3080 3092
204. A.J. Tilbrook, A.I. Turner, and I.J. Clarke Stress and reproduction: central mechanisms and sex differences in non-rodent species Stress 5 2002 83 100
205. D. Toranzo, E. Dupont, J. Simard, C. Labrie, J. Couet, F. Labrie, and G. Pelletier Regulation of pro-gonadotropin-releasing hormone gene expression by sex steroids in the brain of male and female rats Mol. Endocrinol. 3 1989 1748 1756
206. H.F. Urbanski, R.B. White, R.D. Fernald, S.G. Kohama, V.T. Garyfallou, and V.S. Densmore Regional expression of mRNA encoding a second form of gonadotropin-releasing hormone in the macaque brain Endocrinology 140 1999 1945 1948
207. E. Vijayan, and S.M. McCann Re-evaluation of the role of catecholamines in control of gonadotropin and prolactin release Neuroendocrinology 25 1978 150 165
208. E. Vijayan, and S.M. McCann The effect of systemic administration of dopamine and apomorphine on plasma LH and prolactin concentrations in conscious rats Neuroendocrinology 25 1978 221 235
209. M.L. Vitale, and S.R. Chiocchio Serotonin, a neurotransmitter involved in the regulation of luteinizing hormone release Endocr. Rev. 14 1993 480 493
210. H. Wang, S. Li, and G. Pelletier Role of nitric oxide in the regulation of gonadotropin-releasing hormone and tyrosine hydroxylase gene expression in the male rat brain Brain Res. 792 1998 66 71
211. G.D. Weesner, P.G. Harms, N.H. McArthur, J.M. Wilson, D.W. Forrest, T.J. Wu, and D.W. Pfaff Luteinizing hormone-releasing hormone gene expression in the bovine brain: anatomical localisation and regulation by ovarian state Biol. Rep. 49 1993 431 436
212. G.D. Weesner, L.C. Krey, and D.W. Pfaff Alpha 1 adrenergic regulation of estrogen-induced increases in luteinizing hormone-releasing hormone mRNA levels and release Brain Res. Mol. Brain Res. 17 1993 77 82
213. J.E. Wheaton Regional brain content of luteinizing hormone-releasing hormone in sheep during the estrous cycle, seasonal anestrus, and after ovariectomy Endocrinology 104 1979 839 844
214. J.E. Wheaton, L. Krulich, and S.M. McCann Localization of luteinizing hormone-releasing hormone in the preoptic area and hypothalamus of the rat using radioimmunoassay Endocrinology 97 1975 30 38
215. R.B. White, J.A. Eisen, T.L. Kasten, and R.D. Fernald Second gene for gonadotropin-releasing hormone in humans Proc. Natl. Acad. Sci. U.S.A. 95 1998 305 309
216. S.A. White, T.L. Kasten, C.T. Bond, J.P. Adelman, and R.D. Fernald Three gonadotropin-releasing hormone genes in one organism suggest novel roles for an ancient peptide Proc. Natl. Acad. Sci. U.S.A. 92 1995 8363 8367
217. D.B. Whyte, M.A. Lawson, D.D. Belsham, S.A. Eraly, C.T. Bond, J.P. Adelman, and P.L. Mellon A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons Mol. Endocrinol. 9 1995 467 477
218. J.N. Wiemann, D.K. Clifton, and R.A. Steiner Pubertal changes in gonadotropin-releasing hormone and proopiomelanocortin gene expression in the brain of the male rat Endocrinology 124 1989 1760 1767
219. J.N. Wiemann, D.K. Clifton, and R.A. Steiner Gonadotropin-releasing hormone messenger ribonucleic acid levels are unaltered with changes in the gonadal hormone milieu of the adult male rat Endocrinology 127 1990 523 532
220. M.E. Wierman, J.M. Bruder, and J.K. Kepa Regulation of gonadotropin-releasing hormone (GnRH) gene expression in hypothalamic neuronal cells Cell Mol. Neurobiol. 15 1995 79 88
221. P.M. Wise, M.J. Smith, D.B. Dubal, M.E. Wilson, S.W. Rau, A.B. Cashion, M. Bottner, and K.L. Rosewell Neuroendocrine modulation and repercussions of female reproductive aging Recent Prog. Horm. Res. 57 2002 235 256
222. W.C. Worthington Blood samples from the pituitary stalk of the rat: method of collection and factors determining volume Nature 210 1966 710 712
223. S. Wray Development of luteinizing hormone releasing hormone neurones J. Neuroendocrinol. 13 2001 3 11
224. S. Wray Molecular mechanisms for migration of placodally derived GnRH neurons Chem. Senses 27 2002 569 572
225. S. Wray, P. Grant, and H. Gainer Evidence that cells expressing luteinizing hormone-releasing hormone mRNA in the mouse are derived from progenitor cells in the olfactory placode Proc. Natl. Acad. Sci. U.S.A. 86 1989 8132 8136
226. T.J. Wu, M.J. Gibson, and J.L. Roberts Effect of N-methyl-d,l-aspartate (NMA) on gonadotropin-releasing hormone (GnRH) gene expression in male mice Brain Res. 862 2000 238 241
227. T.T. Yeo, A.C. Gore, M. Jakubowski, K.W. Dong, M. Blum, and J.L. Roberts Characterization of gonadotropin-releasing hormone gene transcripts in a mouse hypothalamic neuronal GT1 cell line Brain Res. Mol. Brain Res. 42 1996 255 262
228. W.H. Yu, S. Karanth, S.A. Sower, A.F. Parlow, and S.M. McCann The similarity of FSH-releasing factor to lamprey gonadotropin-releasing hormone III (l-GnRH-III) Proc. Soc. Exp. Biol. Med. 224 2000 87 92
229. W.H. Yu, S. Karanth, A. Walczewska, S.A. Sower, and S.M. McCann A hypothalamic follicle-stimulating hormone-releasing decapeptide in the rat Proc. Natl. Acad. Sci. U.S.A. 94 1997 9499 9503
230. R.T. Zoeller, P.H. Seeburg, and W.S. Young In situ hybridization histochemistry for messenger ribonucleic acid (mRNA) encoding gonadotropin-releasing hormone (GnRH): effect of estrogen on cellular levels of GnRH mRNA in female rat brain Endocrinology 122 1988 2570 2577
231. R.T. Zoeller, and W.S. Young Changes in cellular levels of messenger ribonucleic acid encoding gonadotropin-releasing hormone in the anterior hypothalamus of female rats during the estrous cycle Endocrinology 123 1988 1688 1689