Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: Pathogenic implications for ischemic cardiomyopathy

Age

Volumn 28, Issue 1, 2006, Pages 85-91

  Smith, Mark A ^a   Zhu, Xiongwei ^a   Lee, Hyoung Gon ^a   Harris, Peggy L R ^a   Fortino, Anne E ^b   Perry, George ^a   Castellani, Rudy J ^c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Binucleation; Cell cycle; Immunocytochemistry; Ki 67; Mitosis; Myocardial infarct; Myocyte; p27; Proliferation

Indexed keywords

KI 67 ANTIGEN; PROTEIN P27;

ARTICLE; CARDIOMYOPATHY; CELL CYCLE; CELL PROLIFERATION; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CYTOPLASM; DEGENERATIVE DISEASE; HEART INFARCTION; HEART MUSCLE CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; ISCHEMIC HEART DISEASE; MITOSIS INDEX;

EID: 33746904661     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-006-9001-0     Document Type: Article

References (29)

1. Agah R, Kirshenbaum LA, Abdellatif M et al (1997) Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo. J Clin Invest 100:2722-2728
2. Baldassarre G, Belletti B, Bruni P et al (1999) Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells. J Clin Invest 104:865-874
3. Beltrami AP, Urbanek K, Kajstura J et al (2001) Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 344:1750-1757
4. Blain SW, Massague J (2002) Breast cancer banishes p27 from nucleus. Nat Med 8:1076-1078
5. Carrano AC, Eytan E, Hershko A, Pagano M (1999) SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1:193-199
6. Ciaparrone M, Yamamoto H, Yao Y et al (1998) Localization and expression of p27KIP1 in multistage colorectal carcinogenesis. Cancer Res 58:114-122
7. Esposito G, Rapacciuolo A, Naga Prasad SV et al (2002) Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation 105:85-92
8. Izumo S, Nadal-Ginard B, Mahdavi V (1988) Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci USA 85:339-343
9. Kajstura J, Leri A, Finato N et al (1998) Myocyte proliferation in end-stage cardiac failure in humans. Proc Natl Acad Sci USA 95:8801-8805
10. Liang J, Zubovitz J, Petrocelli T et al (2002) PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 8:1153-1160
11. McShea A, Harris PL, Webster KR, Wahl AF, Smith MA (1997) Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am J Pathol 150:1933-1939
12. Narula J, Haider N, Virmani R et al (1996) Apoptosis in myocytes in end-stage heart failure. N Engl J Med 335:1182-1189
13. Ogawa O, Lee HG, Zhu X et al (2003) Increased p27, an essential component of cell cycle control, in Alzheimer's disease. Aging Cell 2:105-110
14. Olivetti G, Cigola E, Maestri R et al (1996) Aging, cardiac hypertrophy and ischemic cardiomyopathy do not affect the proportion of mononucleated and multinucleated myocytes in the human heart. J Mol Cell Cardiol 28:1463-1477
15. Olivetti G, Abbi R, Quaini F et al (1997) Apoptosis in the failing human heart. N Engl J Med 336:1131-1141
16. Raina AK, Zhu X, Rottkamp CA et al (2000) Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease. J Neurosci Res 61:128-133
17. Reynisdottir I, Polyak K, Iavarone A, Massague J (1995) Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev 9:1831-1845
18. Sadoshima J, Izumo S (1997) The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol 59:551-571
19. Sano M, Abdellatif M, Oh H et al (2002) Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Nat Med 8:1310-1317
20. Singh SP, Lipman J, Goldman H et al (1998) Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma. Cancer Res 58:1730-1735
21. Sternberger LA (1986) Immunocytochemistry. Wiley, New York
22. Sutterluty H, Chatelain E, Marti A et al (1999) p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nat Cell Biol 1:207-214
23. Tamamori-Adachi M, Ito H, Sumrejkanchanakij P et al (2003) Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation. Circ Res 92:e12-e19
24. Tortosa A, Vinolas N, Villa S et al (2003) Prognostic implication of clinical, radiologic, and pathologic features in patients with anaplastic gliomas. Cancer 97:1063-1071
25. Ueno H, Perryman MB, Roberts R, Schneider MD (1988) Differentiation of cardiac myocytes after mitogen withdrawal exhibits three sequential states of the ventricular growth response. J Cell Biol 107:1911-1918
26. Verdecchia P, Carini G, Circo A et al (2001) Left ventricular mass and cardiovascular morbidity in essential hypertension: the MAVI study. J Am Coll Cardiol 38:1829-1835
27. Viglietto G, Motti ML, Bruni P et al (2002) Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med 8:1136-1144
28. Xiao G, Mao S, Baumgarten G et al (2001) Inducible activation of c-myc in adult myocardium in vivo provokes cardiac myocyte hypertrophy and reactivation of DNA synthesis. Circ Res 89:1122-1129
29. Zhu X, Rottkamp CA, Boux H et al (2000) Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease. J Neuropathol Exp Neurol 59:880-888