Up-regulation of cytosolic phospholipase A2α expression by N,N-diethyldithiocarbamate in PC12 cells; involvement of reactive oxygen species and nitric oxide

Toxicology and Applied Pharmacology

Volumn 215, Issue 2, 2006, Pages 218-227

  Akiyama, Nobuteru ^a   Nabemoto, Maiko ^a   Hatori, Yoshio ^a   Nakamura, Hiroyuki ^a   Hirabayashi, Tetsuya ^a   Fujino, Hiromichi ^a   Saito, Takeshi ^b   Murayama, Toshihiko ^a  

^a CHIBA UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Cytosolic phospholipase A2; N,N diethyldithiocarbamate; Nitric oxide; PC12 cells; Reactive oxygen species; Superoxide dismutase

Indexed keywords

ARACHIDONIC ACID; CALCIUM IONOPHORE; DIETHYLDITHIOCARBAMIC ACID; DISULFIRAM; LIPOCORTIN 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OXYHEMOGLOBIN; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 ALPHA; PHOSPHOLIPASE A2 INHIBITOR; REACTIVE OXYGEN METABOLITE; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; NERVE CELL; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; ANNEXIN A1; ANTIVIRAL AGENTS; ARACHIDONIC ACID; CELL SURVIVAL; CYTOSOL; DITIOCARB; DRUG ANTAGONISM; GENE EXPRESSION; MITOGEN-ACTIVATED PROTEIN KINASE 3; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OXYHEMOGLOBINS; PC12 CELLS; PHOSPHOLIPASES A; RATS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SUPEROXIDE DISMUTASE; UP-REGULATION;

EID: 33746897311     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.02.013     Document Type: Article

References (44)

1. 2α level in rat PC12 cells. Neurosci. Lett. 365 (2004) 218-222
2. 2α mRNA levels by reactive oxygen species via MAP kinase pathways in PC12 cells: effects of dopaminergic neurotoxins. Cell Signal 17 (2005) 597-604
3. 2 pathway in production of reactive oxygen species in Alzheimer's disease. Neurochem. Res. 28 (2003) 319-326
4. Aruoma O.I., Halliwell B., Hoey B.M., and Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radical Biol. Med. 6 (1989) 593-597
5. Bai O., Wei Z., Lu W., Bowen R., Keegan D., and Li X.M. Protective effects of atypical antipsychotic drugs on PC12 cells after serum withdrawal. J. Neurosci. Res. 69 (2002) 278-283
6. 2. Nature 390 (1997) 622-625
7. Burkitt M.J., Bishop H.S., Milne L., Tsang S.Y., Provan G.J., Nobel C.S.I., Orrenius S., and Slater A.F.G. Dithiocarbamate toxicity toward thymocytes involves their copper-catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species. Arch. Biochem. Biophys. 353 (1998) 73-84
8. 2+ complex. Eur. J. Pharmacol. 414 (2001) 177-188
9. Cheng S.Y., and Trombetta L.D. The induction of amyloid precursor protein and α-synuclein in rat hippocampal astrocytes by diethyldithiocarbamate and copper with or without glutathione. Toxicol. Lett. 146 (2004) 139-149
10. 2. Neurochem. Res. 29 (2004) 1961-1977
11. Gligun-Sherki Y., Rosenbaum Z., Melamed E., and Offen D. Antioxidant therapy in acute central nervous system injury: current state. Pharmacol. Rev. 54 (2002) 271-284
12. 2. Biol. Pharm. Bull. 27 (2004) 1168-1173
13. Ishikawa A., Kubota Y., Murayama T., and Nomura Y. Cell death by 1-chloro-2,4-dinitrobenzene, an inhibitor of thioredoxin reductase and its dual regulation by nitric oxide in rats. Neurosci. Lett. 277 (1999) 99-102
14. Kalisch B.E., Bock N.A., Davis W.L., and Rylett R.J. Inhibitors of nitric oxide synthase attenuate nerve growth factor-mediated increases in choline acetyltransferase expression in PC12 cells. J. Neurochem. 81 (2002) 624-635
15. Kalisch B.E., Demeris C.S., Ishak M., and Rylett R.J. Modulation of nerve growth factor-induced activation of MAP kinase in PC12 cells by inhibitors of nitric oxide synthase. J. Neurochem. 87 (2003) 1321-1332
16. Kamata H., Tanaka C., Yagisawa H., Matsuda S., Gotoh Y., Nishida E., and Hirata H. Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. J. Biol. Chem. 271 (1996) 33018-33025
17. 2. J. Biol. Chem. 272 (1997) 16709-16712
18. 2) and hydroxynonenal (HNE) in neurons of the lateral septum following fimbria-fornix transection. Exp. Brain Res. 138 (2001) 500-508
19. Lukiw W.J., and Bazan N.G. Neuroinflammatory signaling upregulation in Alzheimer's disease. Neurochem. Res. 25 (2000) 1173-1184
20. Mankhetkorn A., Abedinzadeh Z., and Houée-Levin C. Antioxidant action of sodium diethyldithiocarbamate: reaction with hydrogen peroxide and superoxide radical. Free Radical Biol. Med. 17 (1994) 517-527
21. Montine T.J., Underhill T.M., Valentine W.M., and Graham D.G. Dialkyldithiocarbamates inhibit tyrosine hydroxylase activity in PC12 cells and in fibroblasts that express tyrosine hydroxylase. Neurodegeneration 4 (1995) 283-290
22. Moskowitz S.I., Basu S.B., and Bergold P.J. Chronic and cyclical neuronal loss in hippocampal slice cultures following transient inhibition of the type 1 isoform of superoxide dismutase. Brain Res. 913 (2001) 207-219
23. Myhre O., Andersen J.M., Aarnes H., and Fonnum F. Evaluation of the probes 2′,7′-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation. Biochem. Pharmacol. 65 (2003) 1575-1582
24. Nakamura H., Takashiro Y., Hirabayashi T., Horie S., Koide Y., Nishida A., and Murayama T. Effects of synthetic sphingosine-1-phosphate analogs on arachidonic acid metabolism and cell death. Biochem. Pharmacol. 68 (2004) 2187-2196
25. Pande V., and Ramos M.J. Nuclear factor kappa B: a potential target for anti-HIV chemotherapy. Curr. Med. Chem. 10 (2003) 1603-1615
26. Pompeia C., Lima T., and Curi R. Arachidonic acid cytotoxicity: can arachidonic acid be a physiological mediator of cell death?. Cell Biochem. Funct. 21 (2003) 97-104
27. 2 by oncogenic Ras is mediated through the JNK and ERK pathways in rat epithelial cells. J. Biol. Chem. 276 (2001) 1226-1232
28. 2, potentiates hydrogen peroxide cytotoxicity in kidney epithelial cells. J. Biol. Chem. 271 (1996) 21505-21513
29. Schonhoff C.M., Bulseco D.A., Brancho D.M., Parada L.F., and Ross A.H. The Ras-ERK pathway is required for the induction of neuronal nitric oxide synthase in differentiating PC12 cells. J. Neurochem. 78 (2001) 631-639
30. Siwik D.A., Tzortzis J.D., Pimental D.R., Chang D.L.F., Pagano P.J., Singh K., Sawyer D.B., and Colucci W.S. Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro. Circ. Res. 85 (1999) 147-153
31. 2 activity. Br. J. Pharmacol. 124 (1998) 1675-1683
32. Suzukawa K., Miura K., Mitsushita J., Resau J., Hirose K., Crystal R., and Kamata T. Nerve growth factor-induced neuronal differentiation requires generation of Rac 1-regulated reactive oxygen species. J. Biol. Chem. 275 (2000) 13175-13178
33. Takeuchi A., Miyaishi O., Kiuchi K., and Isobe K. Cu/Zn- and Mn-superoxide dismutases are specifically up-regulated in neurons after focal brain injury. J. Neurobiol. 45 (2000) 39-46
34. 2. Mol. Pharmacol. 65 (2004) 964-972
35. Tonkin E.G., Valentine H.L., Zimmerman L.J., and Valentine W.M. Parenteral N,N-diethyldithiocarbamate produces segmental demyelination in the rat that is not dependent on cysteine carbamylation. Toxicol. Appl. Pharmacol. 189 (2003) 139-150
36. Tonkin E.G., Valentine H.L., Milatovic D.M., and Valentine W.M. N,N-Diethyldithiocarbamate produces copper accumulation, lipid peroxidation, and myelin injury in ray peripheral nerve. Toxicol. Sci. 81 (2004) 160-171
37. Troy C.M., Derossi D., Prochiantz A., Greene L.A., and Shelanski M.L. Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway. J. Neurosci. 16 (1996) 253-261
38. Vaccari A., Saba P.L., Ruiu S., Collu M., and Devoto P. Disulfiram and diethyldithiocarbamate intoxication affects the storage and release of striatal dopamine. Toxicol. Appl. Pharmacol. 139 (1996) 102-108
39. Vaccari A., Ferraro L., Saba P., Ruiu S., Mocci I., Antonelli T., and Tanganelli S. Differential mechanisms in the effects of disulfiram and diethyldithiocarbamate intoxication on striatal release and vesicular transport of glutamate. J. Pharmacol. Exp. Ther. 285 (1998) 961-967
40. Vaglini F., Pardini C., Bonuccelli U., Maggio R., and Corsini G.U. Dextromethorphan prevents the diethyldithiocarbamate enhancement of 1-methyl-4-phenyl-1,2,3,6-tetrahtdropyridine toxicity in mice. Brain Res. 973 (2003) 298-302
41. Wei Z., Bai O., Richardson S.R., Mousseau D.D., and Li X.M. Olanzapine protects PC12 cells from oxidative stress induced by hydrogen peroxide. J. Neurosci. Res. 73 (2003) 364-368
42. 2 gene expression in human bronchial epithelial cells. Biochim. Biophys. Acta 1310 (1996) 175-184
43. Yamazaki M., Chiba K., Mohri T., and Hatanaka H. Activation of the mitogen-activated protein kinase cascade through nitric oxide synthesis as a mechanism of neuritogenic effect of genipin in PC12h cells. J. Neurochem. 79 (2001) 45-54
44. 2 in cell death induced by 1-methyl-4-phenylpyridinium ion, a dopaminergic neurotoxin, in GH3 cells. Brain Res. 855 (2000) 244-251