Stereoselective quantification of methadone and a d6-labeled isotopomer using high performance liquid chromatography-atmospheric pressure chemical ionization mass-spectrometry: Application to a pharmacokinetic study in a methadone maintained subject

Therapeutic Drug Monitoring

Volumn 28, Issue 4, 2006, Pages 559-567

  Foster, David J R ^a   Morton, Erin B ^a   Heinkele, Georg ^b   Mürdter, Thomas E ^b   Somogyi, Andrew A ^c  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

^c DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

Author keywords

Enantiomers; LCMS; Methadone; Pharmacokinetic; Stable labeled

Indexed keywords

METHADONE;

ACCURACY; ADULT; ARTICLE; ASSAY; CALIBRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IONIZATION; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; STEREOCHEMISTRY;

ADMINISTRATION, ORAL; ADULT; AREA UNDER CURVE; ATMOSPHERIC PRESSURE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEUTERIUM; DRUG ADMINISTRATION SCHEDULE; HALF-LIFE; HUMANS; INJECTIONS, INTRAVENOUS; ISOTOPE LABELING; MALE; METABOLIC CLEARANCE RATE; METHADONE; MOLECULAR STRUCTURE; NARCOTICS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; SUBSTANCE WITHDRAWAL SYNDROME; TISSUE DISTRIBUTION;

EID: 33746846139     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200608000-00012     Document Type: Article

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