Population-based pharmacokinetic approach for methadone monitoring of opiate addicts: Potential clinical utility

Addiction

Volumn 95, Issue 12, 2000, Pages 1771-1783

  Wolff, K ^a,b,c,d   Rostami Hodjegan, A ^a,b,c,d   Hay, A W M ^a,b,c,d   Raistrick, D ^a,b,c,d   Tucker, G ^a,b,c,d  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d Leeds Addiction Unit   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

METHADONE;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG MONITORING; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAINTENANCE THERAPY; MALE; METHADONE TREATMENT; OPIATE ADDICTION; PATIENT COMPLIANCE; POPULATION RESEARCH; TREATMENT FAILURE;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; BAYES THEOREM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG MONITORING; FEMALE; HALF-LIFE; HEROIN DEPENDENCE; HUMANS; MALE; METHADONE; NARCOTICS; PATIENT COMPLIANCE; PREDICTIVE VALUE OF TESTS;

EID: 0034531092     PISSN: 09652140     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1360-0443.2000.951217717.x     Document Type: Article

References (66)

1. 1id glycoprotein
2. 1-acid glycoprotein and antipyrine clearance in the dog
3. Disposition of methadone in methadone maintenance
4. Reducing the risk of AIDS through methadone maintenance treatment
5. Dihydrocodeine as a useful clinical tool for detoxification from methadone maintenance treatment
6. Therapeutic drug monitoring of methadone in HIV-infected patients receiving protease inhibitors
7. Accidental ingestion of methadone by children in Merseyside
8. Pharmacokinetic interaction of antimicrobial agents with levomethadone in drug-addicted AIDS patients
9. 1-acid glycoprotein and serum protein binding of methadone in heroin addicts during withdrawal
10. Only half of patients store methadone in a safe place
11. Deaths in the first two weeks of maintenance treatment in NSW in 1994: Identifying cases of iatrogenic methadone toxicity
12. Patterns of symptom complaints in methadone maintenance patients
13. Nomenclature and classification of drug and alcohol-related problems: A shortened version of a WHO memorandum
14. Replacement of (R)-methadone by a double dose of (R, S)-methadone in addicts: Interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics
15. Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of enantiomers of methadone
16. Drug misusers: Whose business is it?
17. Suicide and overdose among opiate addicts
18. The prevalence and consequences of harmful drinking in methadone maintenance patients
19. Diversion tactics: How a sample of drug misusers in treatment obtained surplus drugs to sell on the illicit market
20. Alpha-1 acid glycoprotein (AAG) and serum protein binding of methadone in heroin addicts with abstinence syndrome
21. Best practice in therapeutic drug monitoring
22. Trends in opiate over-dose deaths in Australia 1979-1995
23. Two new rating scales for opiate withdrawal
24. Fatal methadone overdose
25. 1-acid glycoprotein
26. Subjective and objective symptoms in relation to plasma methadone concentration in methadone patients
27. Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes
28. Inhibition of methadone and buprenorphine N-dealkylations by three HIV-1 protease inhibitors
29. Interaction of methadone with substrates of human hepatic cytochrome
30. Pharmacokinetics of methadone
31. 1-acid glycoprotein limits the blood to brain transfer of drugs it binds
32. Risk factors among IDUs who give injections to or receive injections from other drug users
33. Use of psychotropic drugs in the treatment of methadone maintained narcotic addicts
34. The use of plasma levels to optimise methadone maintenance treatment
35. Outpatient methadone withdrawal for heroin dependence
36. Methadone does and psychopathological symptoms during methadone maintenance
37. Methadone, methadone treatment and non-fatal overdose
38. Fatal methadone and heroin overdoses: Time trends in England and Wales
39. Pharmacokinetics of methadone during maintenance treatment: Adaptive changes during the inductive phase
40. Pharmacokinetics of methadone in methadone maintenance treatment: Characterisation of therapeutic failures
41. Methadone binding to human plasma proteins
42. Disease-induced changes in the plasma binding of basic drugs
43. Methadone maintenance and tuberculosis treatment
44. Pharmacology
45. Population pharmacokinetics in opiate users: Characterisation of time-dependent changes
46. Limits of confidence in tracer compounds as a means of measuring patients compliance with medication
47. Prescribing injectable and oral methadone to opiate addicts: Results from the 1995 national postal survey of community pharmacies in England and Wales
48. Plasma methadone concentrations as an indicator of opioid withdrawal symptoms and heroin use in a methadone maintenance program
49. DSM-III personality type and dose levels in methadone maintenance patients
50. Phenytoin induced methadone withdrawal
51. Methadone in man: Pharmacokinetic and excretion studies in acute and chronic treatment
52. Pharmacotherapy in the treatment of drug dependence: Options to strengthen effectiveness
53. Therapeutic drug monitoring for methadone
54. Therapeutic drug monitoring for methadone: Scanning the horizon
55. Plasma methadone monitoring with methadone maintenance treatment
56. Plasma methadone measurements and their role in methadone detoxification programs
57. Steady-state pharmacokinetics of methadone in opioid addicts
58. Measuring compliance in methadone maintenance patients: Use of a pharmacologic indicator to "estimate" methadone plasma levels
59. The pharmacokinetics of methadone in healthy volunteers and opiate users
60. Methadone concentrations in plasma and their relationship to drug dosage
61. Deaths of heroin addicts starting on methadone maintenance
62. Deaths in methadone maintenance treatment in New South Wales, Australia 1990-1995