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Volumn 1073, Issue 1-2, 2005, Pages 237-248

Determination of total and free concentrations of the enantiomers of methadone and its metabolite (2-ethylidene-1,5-dimethyl-3,3-diphenyl- pyrrolidine) in human plasma by enantioselective liquid chromatography with mass spectrometric detection

(6) Rodriguez Rosas, Maria Esther a Medrano, Juan G a Epstein, David H b Moolchan, Eric T b Preston, Kenzie L b Wainer, Irving W a

a NATIONAL INSTITUTE ON AGING (United States)

b NATIONAL INSTITUTE ON DRUG ABUSE (United States)

Author keywords

(R) Methadone; (S) Methadone; AGP chiral stationary phase; Chiral chromatography

Indexed keywords

ACETONITRILE; ASSAYS; CORRELATION METHODS; DRUG PRODUCTS; ION EXCHANGE; MASS SPECTROMETRY; SEPARATION; SOLVENT EXTRACTION; ULTRAFILTRATION;

ENANTIOMERS; LOWER LIMIT OF QUANTIZATION (LLOQ); METHADONE-2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE (EDDP); SOLID-PHASE EXTRACTION;

LIQUID CHROMATOGRAPHY;

2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; ACETONITRILE; AMMONIUM ACETATE; BUFFER; DEUTERIUM; DRUG METABOLITE; ION; METHADONE; OROSOMUCOID; UNCLASSIFIED DRUG;

ACCURACY; CATION EXCHANGE; CENTRIFUGATION; CHEMICAL LABELING; CHIRALITY; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION COEFFICIENT; DEVICE; DRUG BLOOD LEVEL; DRUG DETERMINATION; ENANTIOMER; ENANTIOSELECTIVITY; EVAPORATION; EXTRACTION; FEMALE; FLOW RATE; HEMOCONCENTRATION; HUMAN; INJECTION; ION MONITORING; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; PATIENT; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SAMPLE; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; STANDARD; TEMPERATURE; ULTRAFILTRATION; VALIDATION PROCESS;

EID: 17444421220 PISSN: 00219673 EISSN: None Source Type: Journal
DOI: 10.1016/j.chroma.2004.08.153 Document Type: Conference Paper

Times cited : (34)

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