Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients

British Journal of Clinical Pharmacology

Volumn 50, Issue 5, 2000, Pages 427-440

  Foster, D J R ^a   Somogyi, A A ^a   Dyer, K R ^a   White, J M ^a   Bochner, F ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

2 ethylidene 1,5 dimethyl 3,3 diphenylpyrrolidine; Drug dependence; Metabolism; Methadone; Pharmacokinetics; Protein binding; Stereoselectivity

Indexed keywords

2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; CYTOCHROME P450 3A4; DRUG METABOLITE; METHADONE; OROSOMUCOID; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DEPENDENCE; DRUG METABOLISM; DRUG MONITORING; DRUG PROTEIN BINDING; DRUG URINE LEVEL; ENANTIOMER; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KIDNEY CLEARANCE; MALE; OPIATE ADDICTION; PLASMA CLEARANCE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; STEADY STATE; STEREOCHEMISTRY; ULTRAFILTRATION;

ADULT; AREA UNDER CURVE; FEMALE; HUMANS; INDIVIDUALITY; KIDNEY; LINEAR MODELS; MALE; METHADONE; MIDDLE AGED; NARCOTICS; OROSOMUCOID; PROTEIN BINDING; PYRROLIDINES; STEREOISOMERISM; SUBSTANCE-RELATED DISORDERS; SUBSTRATE SPECIFICITY;

EID: 0033747394     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2000.00272.x     Document Type: Article

References (51)

1. A medical treatment for diacetylmorphine (heroin) addiction
2. Methadone maintenance treatment in opiate dependence: A review
3. 2, δ, u opioid receptor binding profiles of methadone stereoisomers and morphine
4. Pharmacologic comparison of the optical isomers of methadon
5. The efficacy of L-methadone and racemic methadone in substitution treatment for opiate addicts-a double-blind comparison
6. The addiction liability of some of the drugs of the methadon series
7. Metabolism of d-methadone: Isolation and identification of analgesically active metabolises
8. Urinary metabolites of dl-methadone in maintenance subjects
9. Altered methadone pharmacokinetics in methadone-maintained pregnant women
10. Disposition of methadone in methadone maintenance
11. Effects of liver disease on urinary excretion of methadone and metabolites in maintenance patients: Quantitation by direct probe chemical ionization mass spectrometry
12. Stereoselective pharmacokinetics of methadone in chronic pain patients
13. Enantioselective high-performance liquid chromatography determination of methadone enantiomers and its major metabolite in human biological fluids using a new derivatized cyclodextrin-bonded phase
14. Chiral analysis of methadone in plasma by high-performance liquid chromatography
15. Replacement of (R)-methadone by a double dose of (R,S) -methadone in addicts: Interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics
16. Stereoselective disposition of methadone in man
17. 8]-Methadone
18. 1-acid glycoprotein
19. 1-acid glycoprotein): Determinant of free fraction in plasma
20. Steady-state pharmacokinetics and pharmacodynamics in methadone maintenance patients: Comparison of those who do and do not experience withdrawal and concentration-effect relationships
21. Sensitive high-performance liquid chromatographic assay with ultraviolet detection of methadone enantiomers in plasma
22. Chiral stationary phases in HPLC for the stereoselective determination of methadone
23. Stereoselective quantification of methadone and its major oxidative metabolite, EDDP, in human urine using stereoselective high-performance liquid chromatography
24. Ultrafiltration using the Amicon MPS-1 for assessing methadone plasma protein binding
25. Comparing methods of measurements
26. Fitting straight lines to experimental data
27. Methadone N-demethylation in human liver microsomes: Lack of stereoselectivity and involvement of CYP3A4
28. Effects of liver disease on fecal excretion of methadone and its unconjugated metabolites in maintenance patients. Quantitation by direct probe chemical ionization mass spectrometry
29. Methadone in man: Pharmacokinetic and excretion studies in acute and chronic treatment
30. Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes
31. Interaction of methadone with substrates of human hepatic cytochrome P450 3A4
32. The involvement of cytochrome P450 3A4 in the N-demethylation of 1-α-acetylmethadol (laam), norlaam, and methadone
33. Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics
34. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
35. In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse
36. Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients
37. Use of midazolam as a human cytochrome P4503A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation
38. The erythromycin breath test predicts the clearance of midazolam
39. Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism
40. The pharmacokinetics of methadone in healthy subjects and opiate users
41. Population pharmacokinetics of methadone in opiate users: Characterization of time-dependent changes
42. Methadone concentrations in plasma and their relationship to drug dosage
43. Steady-state pharmacokinetics of methadone in opioid addicts
44. 1-acid glycoprotein
45. 1-acid glycoprotein
46. Binding of codeine, morphine, and methadone to human serum proteins
47. Influence of plasma pH on quinidine uptake by erythrocytes: Estimation of free drug fraction in plasma from blood/and erythrocyte/plasma concentration ratios
48. 1-acid glycoprotein
49. Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain
50. Methadone maintenance: Effect of urinary pH on renal clearance in chronic high and low doses
51. Effect of urinary pH on the disposition of methadone in man