Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 31, 2006, Pages 11491-11496

  Pojer, Florence ^a   Ferrer, Jean Luc ^b   Richard, Stéphane B ^a   Nagegowda, Dinesh A ^c   Chye, Mee Len ^c   Bach, Thomas J ^d   Noel, Joseph P ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d CNRS   (France)

Author keywords

Cholesterol lowering; F 244; Inhibition; Mevalonate; X ray structure

Indexed keywords

12 HYDROXY 13 HYDROXYMETHYL 3,5,7 TRIMETHYLTETRADECA 2,4 DIENEDIOIC ACID 12,14 LACTONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; ISOPRENOID; MEVALONIC ACID; NATURAL PRODUCT;

ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CATALYSIS; COVALENT BOND; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; EUKARYOTE; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROKARYOTE; RAT; SPECIES DIFFERENCE; X RAY DIFFRACTION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FATTY ACIDS, UNSATURATED; HUMANS; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; LACTONES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUSTARD PLANT; PLANT PROTEINS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EUKARYOTA; PROKARYOTA;

EID: 33746835442     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0604935103     Document Type: Article

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