The transforming growth factor-β-Smad3/4 signaling pathway acts as a positive regulator for TLR2 induction by bacteria via a dual mechanism involving functional cooperation with NF-κB and MAPK phosphatase 1-dependent negative cross-talk with p38 MAPK

Journal of Biological Chemistry

Volumn 281, Issue 31, 2006, Pages 22397-22408

  Mikami, Fumi ^a,b   Jae, Hyang Lim ^a,b   Ishinaga, Hajime ^a,b   Ha, Un Hwan ^a,b   Gu, He ^b   Koga, Tomoaki ^a,b   Jono, Hirofumi ^a,b   Kai, Hirofumi ^c   Li, Jian Dong ^a,b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BACTERIA; CELLS; GROWTH KINETICS; IMMUNOLOGY; PHOSPHORUS;

APOPTOSIS; CELL PROLIFERATION; NONTYPEABLE HEMOPHILUS INFLUENZAE (NTHI); TOLL LIKE RECEPTORS (TLR);

PROTEINS;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; SMAD3 PROTEIN; SMAD4 PROTEIN; TOLL LIKE RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ARTICLE; CONTROLLED STUDY; HAEMOPHILUS INFLUENZAE TYPE A; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL;

BACTERIA; BACTERIAL INFECTIONS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; IMMUNITY; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR CROSS-TALK; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD4 PROTEIN; TOLL-LIKE RECEPTOR 2; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

BACTERIA (MICROORGANISMS); HAEMOPHILUS INFLUENZAE;

EID: 33746804960     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602124200     Document Type: Article

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