-
1
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
-
Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, et al. (1997) Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res 25:3389-3402
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schaffer, A.A.3
Zhang, J.4
Zhang, Z.5
Miller, W.6
-
2
-
-
33746662730
-
A novel actinomycete strain de-replication approach based on the diversity of polyketide synthase and non-ribosomal peptide synthase biosynthetic pathways
-
Ayuso A, Clark D, Gonzalez I, Salazar O, Anderson A, Genilloud O (2005) A novel actinomycete strain de-replication approach based on the diversity of polyketide synthase and non-ribosomal peptide synthase biosynthetic pathways. App Microbiol Biotech 96:539-542
-
(2005)
App Microbiol Biotech
, vol.96
, pp. 539-542
-
-
Ayuso, A.1
Clark, D.2
Gonzalez, I.3
Salazar, O.4
Anderson, A.5
Genilloud, O.6
-
3
-
-
0032876464
-
Ketosynthase domain probes identify two subclasses of fungal polyketide synthase genes
-
Bingle LEH, Simpson TJ, Lazarus CM (1999) Ketosynthase domain probes identify two subclasses of fungal polyketide synthase genes. Fung Gen Biol 26:209-223
-
(1999)
Fung Gen Biol
, vol.26
, pp. 209-223
-
-
Bingle, L.E.H.1
Simpson, T.J.2
Lazarus, C.M.3
-
4
-
-
0034047123
-
Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: Analysis of the gene cluster and deduction of the biosynthetic pathway
-
Brautaset T, Sekurova ON, Sletta H, Ellingsen TE, Strom AR, Valla S, et al. (2000) Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: Analysis of the gene cluster and deduction of the biosynthetic pathway. Chem Biol 7:395-403
-
(2000)
Chem Biol
, vol.7
, pp. 395-403
-
-
Brautaset, T.1
Sekurova, O.N.2
Sletta, H.3
Ellingsen, T.E.4
Strom, A.R.5
Valla, S.6
-
5
-
-
0026697224
-
Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea
-
Caffrey P, Bevitt DJ, Staunton J, Leadlay PF (1992) Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea. FEBS Lett 304:225-228
-
(1992)
FEBS Lett
, vol.304
, pp. 225-228
-
-
Caffrey, P.1
Bevitt, D.J.2
Staunton, J.3
Leadlay, P.F.4
-
6
-
-
0034930476
-
Amphotericin biosynthesis in Streptomyces nodosus: Deductions from analysis of polyketide synthase and late genes
-
Caffrey P, Lynch S, Flood E, Finnan S, Oliynyk M (2001) Amphotericin biosynthesis in Streptomyces nodosus: Deductions from analysis of polyketide synthase and late genes. Chem Biol 8:713-723
-
(2001)
Chem Biol
, vol.8
, pp. 713-723
-
-
Caffrey, P.1
Lynch, S.2
Flood, E.3
Finnan, S.4
Oliynyk, M.5
-
7
-
-
0036148337
-
The candicidin gene cluster from Streptomyces griseus IMRU 3570
-
Campelo AB, Gil JA (2002) The candicidin gene cluster from Streptomyces griseus IMRU 3570. Microbiology 148:51-59
-
(2002)
Microbiology
, vol.148
, pp. 51-59
-
-
Campelo, A.B.1
Gil, J.A.2
-
8
-
-
0031259679
-
Molecular recognition of diketide substrates by a β-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase
-
Chuck JA, McPherson M, Huang H, Jacobsen Khosla JR, Khosla C, Cane DE (1997) Molecular recognition of diketide substrates by a β-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase. Chem Biol 4:757-766
-
(1997)
Chem Biol
, vol.4
, pp. 757-766
-
-
Chuck, J.A.1
McPherson, M.2
Huang, H.3
Jacobsen Khosla, J.R.4
Khosla, C.5
Cane, D.E.6
-
9
-
-
0346035740
-
Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural products
-
Courtois S, Cappellano CM, Ball M, Francou FX, Normand P, Helynck G, et al. (2003) Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural products. Appl Environ Microbiol 69:49-55
-
(2003)
Appl Environ Microbiol
, vol.69
, pp. 49-55
-
-
Courtois, S.1
Cappellano, C.M.2
Ball, M.3
Francou, F.X.4
Normand, P.5
Helynck, G.6
-
10
-
-
0028882479
-
Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae Tu2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation
-
Decker H, Haag S (1995) Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae Tu2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation. J Bacteriol 177:6126-6136
-
(1995)
J Bacteriol
, vol.177
, pp. 6126-6136
-
-
Decker, H.1
Haag, S.2
-
11
-
-
4644371642
-
Phylogenetic analysis of polyketide synthase I domains from soil metagenomic libraries allows selection of promising clones
-
Ginolhac A, Jarrin C, Gillet B, Robe P, Pujic P, Tuphile K, et al. (2004) Phylogenetic analysis of polyketide synthase I domains from soil metagenomic libraries allows selection of promising clones. Appl Environ Microbiol 70:5522-5527
-
(2004)
Appl Environ Microbiol
, vol.70
, pp. 5522-5527
-
-
Ginolhac, A.1
Jarrin, C.2
Gillet, B.3
Robe, P.4
Pujic, P.5
Tuphile, K.6
-
12
-
-
0033982651
-
Role of linkers in communication between protein modules
-
Gokhale RS, Kholsa C (2000) Role of linkers in communication between protein modules. Curr Opin Chem Biol 4:22-27
-
(2000)
Curr Opin Chem Biol
, vol.4
, pp. 22-27
-
-
Gokhale, R.S.1
Kholsa, C.2
-
13
-
-
0028841535
-
Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA: Acyl carrier protein transacylase domains in modular polyketide synthase
-
Haydock SF, Aparicio JF, Molnar I, Schwecke T, Khaw LE, Konig A, et al. (1995) Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA: Acyl carrier protein transacylase domains in modular polyketide synthase. FEBS Lett 374:246-248
-
(1995)
FEBS Lett
, vol.374
, pp. 246-248
-
-
Haydock, S.F.1
Aparicio, J.F.2
Molnar, I.3
Schwecke, T.4
Khaw, L.E.5
Konig, A.6
-
14
-
-
0001747786
-
Genetic contributions to understanding polyketide synthases
-
Hopwood DA (1997) Genetic contributions to understanding polyketide synthases. Chem Rev 97:2465-2498
-
(1997)
Chem Rev
, vol.97
, pp. 2465-2498
-
-
Hopwood, D.A.1
-
15
-
-
0030693291
-
Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis
-
Kakavas SJ, Katz L, Stassi D (1997) Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis. J Bacteriol 179:7515-7522
-
(1997)
J Bacteriol
, vol.179
, pp. 7515-7522
-
-
Kakavas, S.J.1
Katz, L.2
Stassi, D.3
-
17
-
-
0035843184
-
Modular enzymes
-
Khosla C, Harbury PB (2001) Modular enzymes. Nature 409:247-252
-
(2001)
Nature
, vol.409
, pp. 247-252
-
-
Khosla, C.1
Harbury, P.B.2
-
18
-
-
2942674459
-
An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases
-
Kim BS, Sherman DH, Reynolds KA (2004) An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases. Prot Eng Design Select 17:277-284
-
(2004)
Prot Eng Design Select
, vol.17
, pp. 277-284
-
-
Kim, B.S.1
Sherman, D.H.2
Reynolds, K.A.3
-
19
-
-
0242669333
-
Intermodular communication in modular polyketide synthases: Structural and mutational analysis of linker mediated protein-protein recognition
-
Kumar P, Li Q, Cane DE, Khosla C (2003) Intermodular communication in modular polyketide synthases: Structural and mutational analysis of linker mediated protein-protein recognition. J Am Chem Soc 125:4097-4102
-
(2003)
J Am Chem Soc
, vol.125
, pp. 4097-4102
-
-
Kumar, P.1
Li, Q.2
Cane, D.E.3
Khosla, C.4
-
20
-
-
0033514424
-
Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units
-
Lau J, Fu H, Cane DE, Khosla C (1999) Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. Biochemistry 38:1643-1651
-
(1999)
Biochemistry
, vol.38
, pp. 1643-1651
-
-
Lau, J.1
Fu, H.2
Cane, D.E.3
Khosla, C.4
-
21
-
-
0033515090
-
Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel unnaturalnatural products
-
USA
-
McDaniel R, Thamchaipenet A, Gustafsson C, Fu H, Betlach M, et al. (1999) Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel unnaturalnatural products. Proc Natl Acad Sci USA 96:1846-1851
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 1846-1851
-
-
McDaniel, R.1
Thamchaipenet, A.2
Gustafsson, C.3
Fu, H.4
Betlach, M.5
-
22
-
-
0141511495
-
An efficient approach for screening minimal PKS genes from Streptomyces
-
Metsa-Ketela M, Salo V, Halo L, Hautala J, Hakala J, Mantsala P, et al. (1999) An efficient approach for screening minimal PKS genes from Streptomyces. FEMS Microbiol Lett 180:1-6
-
(1999)
FEMS Microbiol Lett
, vol.180
, pp. 1-6
-
-
Metsa-Ketela, M.1
Salo, V.2
Halo, L.3
Hautala, J.4
Hakala, J.5
Mantsala, P.6
-
23
-
-
0029856517
-
6-Deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the b-ketoacyl-ACP synthase domain of module 2
-
Tsukamoto N, Chuck J, Luo G, Kao CM, Khosla C, Cane DE (1996) 6-Deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the b-ketoacyl-ACP synthase domain of module 2. Biochemistry 35:15244-15248
-
(1996)
Biochemistry
, vol.35
, pp. 15244-15248
-
-
Tsukamoto, N.1
Chuck, J.2
Luo, G.3
Kao, C.M.4
Khosla, C.5
Cane, D.E.6
-
24
-
-
0035060868
-
Design and utility of oligonucleotide gene probes for fungal polyketide synthases
-
Nicholson TP, Rudd BA, Dawson M, Lazarus CM, Simpson TJ, Cox RJ (2001) Design and utility of oligonucleotide gene probes for fungal polyketide synthases. Chem Biol 8:157-178
-
(2001)
Chem Biol
, vol.8
, pp. 157-178
-
-
Nicholson, T.P.1
Rudd, B.A.2
Dawson, M.3
Lazarus, C.M.4
Simpson, T.J.5
Cox, R.J.6
-
25
-
-
0242695043
-
High yield preparation of genomic DNA from Streptomyces
-
Nikodinovic J, Barrow KD, Chuck JA (2003) High yield preparation of genomic DNA from Streptomyces. Biotechnology 35:932-936
-
(2003)
Biotechnology
, vol.35
, pp. 932-936
-
-
Nikodinovic, J.1
Barrow, K.D.2
Chuck, J.A.3
-
26
-
-
0035834039
-
Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
-
USA
-
Omura S, Ikeda H, Ishikawa J, Hanamoto A, Takahashi C, Shinose M, et al. (2001) Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites. Proc Natl Acad Sci USA 98:12215-12220
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 12215-12220
-
-
Omura, S.1
Ikeda, H.2
Ishikawa, J.3
Hanamoto, A.4
Takahashi, C.5
Shinose, M.6
-
27
-
-
0024321833
-
Organization and nucleotide sequence analysis of a ribosomal RNA gene cluster from Streptomyces ambofaciens
-
Pernodet JL, Boccard F, Alegre MT, Gagnat J, Guerineau M (1989) Organization and nucleotide sequence analysis of a ribosomal RNA gene cluster from Streptomyces ambofaciens. Gene 79:33-46
-
(1989)
Gene
, vol.79
, pp. 33-46
-
-
Pernodet, J.L.1
Boccard, F.2
Alegre, M.T.3
Gagnat, J.4
Guerineau, M.5
-
28
-
-
0035951074
-
Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations
-
Reeves CD, Murli S, Ashley G, Wendt-Piagentini M, Hutchinson CR, McDaniel R (2001) Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations. Biochemistry 40:15464-15470
-
(2001)
Biochemistry
, vol.40
, pp. 15464-15470
-
-
Reeves, C.D.1
Murli, S.2
Ashley, G.3
Wendt-Piagentini, M.4
Hutchinson, C.R.5
McDaniel, R.6
-
29
-
-
0038544618
-
The enzymology of combinatorial biosynthesis
-
Reeves CD (2003) The enzymology of combinatorial biosynthesis. Crit Rev Biotechnol 23:95-147
-
(2003)
Crit Rev Biotechnol
, vol.23
, pp. 95-147
-
-
Reeves, C.D.1
-
30
-
-
0030690924
-
A study of iterative type II polyketide synthases using bacterial genes cloned from soil DNA: A means to access and use genes from uncultured microorganisms
-
Seow KT, Meurer G, Gerlitz M, Pienkowski EW, Hutchinson RC, Davies J (1997) A study of iterative type II polyketide synthases using bacterial genes cloned from soil DNA: A means to access and use genes from uncultured microorganisms. J Bacteriol 179:7360-7368
-
(1997)
J Bacteriol
, vol.179
, pp. 7360-7368
-
-
Seow, K.T.1
Meurer, G.2
Gerlitz, M.3
Pienkowski, E.W.4
Hutchinson, R.C.5
Davies, J.6
-
31
-
-
0001768101
-
Conserved residues in condensing enzymes domains of fatty acid synthases and related sequences
-
Siggaard-Andersen M (1993) Conserved residues in condensing enzymes domains of fatty acid synthases and related sequences. Prot Seq Data Anal 5:325-335
-
(1993)
Prot Seq Data Anal
, vol.5
, pp. 325-335
-
-
Siggaard-Andersen, M.1
-
32
-
-
0035957078
-
Intermodular communication in polyketide synthases: Comparing the role of protein-protein interactions to those in other multidomain proteins
-
Tsuji SY, Wu N, Khosla C (2001) Intermodular communication in polyketide synthases: Comparing the role of protein-protein interactions to those in other multidomain proteins. Biochemistry 40:2317-2325
-
(2001)
Biochemistry
, vol.40
, pp. 2317-2325
-
-
Tsuji, S.Y.1
Wu, N.2
Khosla, C.3
-
33
-
-
0037117747
-
Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases
-
Wu N, Cane DE, Khosla C (2002) Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases Biochemistry 41:5056-5066
-
(2002)
Biochemistry
, vol.41
, pp. 5056-5066
-
-
Wu, N.1
Cane, D.E.2
Khosla, C.3
-
34
-
-
0032738419
-
Multiplasmid approach to preparing large libraries of polyketides
-
USA
-
Xue Q, Ashley G, Hutchinson CR, Santi DV (1999) Multiplasmid approach to preparing large libraries of polyketides. Proc Natl Acad Sci USA 96:11740-1174
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 11740-21174
-
-
Xue, Q.1
Ashley, G.2
Hutchinson, C.R.3
Santi, D.V.4
|