Essential stations in the intracellular pathway of cytotoxic bovine seminal ribonuclease

Biochemical Journal

Volumn 362, Issue 3, 2002, Pages 553-560

  Bracale, Aurora ^a   Spalletti Cernia, Daniela ^a   Mastronicola, Mariarosaria ^a   Castaldi, Francesco ^a   Mannucci, Roberta ^a   Nitsch, Lucio ^a   D'Alessio, Giuseppe ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Anti tumour; Cytotoxins; Endocytosis; Intracellular traffic

Indexed keywords

CELLS; DERIVATIVES; DRUG PRODUCTS;

INTRACELLULAR PATHWAY;

ENZYMES;

ANTINEOPLASTIC AGENT; CYTOTOXIN; RIBONUCLEASE;

ANIMAL CELL; ARTICLE; CATTLE; CYTOTOXICITY; ENDOCYTOSIS; ENZYME ANALYSIS; IMMUNOFLUORESCENCE; INTERNALIZATION; INTRACELLULAR TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

3T3 CELLS; ANIMALS; CATTLE; CELL LINE, TRANSFORMED; DNA TRANSPOSABLE ELEMENTS; ENDORIBONUCLEASES; ENDOSOMES; FIBROBLASTS; GENITAL NEOPLASMS, MALE; MALE; MICE; NEOPLASM PROTEINS; OLIGOPEPTIDES; PROTEIN SORTING SIGNALS; PROTEIN SUBUNITS; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; SEMEN; TRANS-GOLGI NETWORK; VARIATION (GENETICS);

ANIMALIA; BOS TAURUS; BOVINAE;

EID: 0037086474     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3620553     Document Type: Article

References (35)

1. Seminal ribonuclease: The importance of diversity
2. The effect of bovine seminal ribonuclease (AS RNase) on cells of Crocker tumour in mice
3. Antitumor RNases
4. In vitro studies on selective inhibition of tumor cell growth by seminal ribonuclease
5. Ribonuclease A can be transformed into a dimeric ribonuclease with antitumor activity
6. Ribonuclease A variants with potent cytotoxic activity
7. Engineering receptor-mediated cytotoxicity into human ribonucleases by steric blockade of inhibitor interaction
8. A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells
9. Key extracellular and intracellular steps in the antitumor action of seminal ribonuclease
10. A study of the intracellular routing of the cytotoxic ribonucleases
11. Relationship between response rate and median survival in patients with advanced non-small cell lung cancer: Comparison of onconase with other anticancer agents
12. Single amino acid substitutions at the N-terminus of a recombinant cytotoxic ribonuclease markedly influence biochemical and biological properties
13. A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity
14. Characterisation of the mechanism of cellular and cell free protein synthesis inhibition by an antitumor ribonuclease
15. Toxin entry: Retrograde transport through the secretory pathway
16. Fast and high-yelding procedures for the isolation of bovine seminal RNase
17. Dissociation of bovine seminal ribonuclease into catalytically active monomers by selective reduction and alkylation of the intersubunit disulfide bridges
18. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides
19. Culture of hormone-dependent functional ephitelial cells from rat thyroids
20. The Kirsten murine sarcoma virus induces rat thyroid carcinomas in vivo
21. Use of Exotoxin A to inhibit protein synthesis
22. DNA sequencing with chain-terminating inhibitors
23. Expression of bovine seminal ribonuclease in Escherichia coli
24. A spectrophotometric method for the measurement of ribonuclease activity
25. Bovine seminar ribonuclease destabilizes negatively charged membranes
26. Acidification of endocytic and exocytic pathways
27. Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity
28. Nucleocytoplasmic transport: Signals, mechanisms and regulation
29. Multiple targets for brefeldin A
30. Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic
31. Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin
32. The retention signal for soluble proteins of the endoplasmic reticulum
33. The capacity to retrieve escaped ER proteins extends to the trans-most cisterna of the Golgi stack