A novel SOD-mimetic permeability transition inhibitor agent protects ischemic heart by inhibiting both apoptotic and necrotic cell death

Free Radical Biology and Medicine

Volumn 41, Issue 5, 2006, Pages 835-848

  Bognar, Zita ^a   Kalai, Tamas ^a   Palfi, Anita ^b   Hanto, Katalin ^b   Bognar, Balazs ^a   Mark, Laszlo ^a   Szabo, Zoltan ^a   Tapodi, Antal ^a   Radnai, Balazs ^a   Sarszegi, Zsolt ^a   Szanto, Arpad ^a   Gallyas Jr , Ferenc ^a   Hideg, Kalman ^a   Sumegi, Balazs ^a,c   Varbiro, Gabor ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b Faculty of Medicine   (Hungary)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

apoptosis; Ischemia reperfusion; Langendorff perfused hearts; Mitochondrial permeability transition; necrosis; NMR; ROS

Indexed keywords

2 METHYL 3 [3,5 DIIODO 4 [2 [N ETHYL N (1 HYDROXY 2,2,5,5 TETRAMETHYL 2,5 DIHYDRO 1H DIHYDRO 1H PYRROL 3 YLMETHYL)ETHYL]]OXYBENZOYL]BENZOFURANE; BENZOFURAN DERIVATIVE; HO 3538; MITOCHONDRIAL PROTEIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CARDIOVASCULAR PARAMETERS; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; ENERGY METABOLISM; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PERFUSION; HUMAN; HUMAN CELL; ISOLATED HEART; LIPID PEROXIDATION; MEMBRANE PERMEABILITY; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; STATISTICAL SIGNIFICANCE;

AMIODARONE; ANIMALS; APOPTOSIS; CYTOCHROMES C; HUMANS; ISCHEMIA; JURKAT CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MITOCHONDRIA; MYOCARDIAL INFARCTION; NECROSIS; RATS; RATS, WISTAR; REPERFUSION INJURY; SUPEROXIDE DISMUTASE;

EID: 33746682437     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.06.004     Document Type: Article

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