The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal

Journal of Molecular Medicine

Volumn 84, Issue 8, 2006, Pages 660-670

  Sakai, Yasunari ^a,b   Oda, Hisanobu ^a,c   Yoshimura, Daisuke ^a   Furuichi, Masato ^a   Kang, Dongchon ^b   Iwai, Shigenori ^d   Hara, Toshiro ^b   Nakabeppu, Yusaku ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

2 OH dATP; 8 oxo dGTP; Human MTH1 gene; Mitochondrial localization; Single nucleotide polymorphism

Indexed keywords

DEOXYADENOSINE TRIPHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MUTT HOMOLOG 1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; EXON; GENE; HUMAN; HUMAN CELL; MITOCHONDRION; PROTEIN HYDROLYSIS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADENOSINE TRIPHOSPHATE; ALTERNATIVE SPLICING; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CELL LINE; DNA REPAIR ENZYMES; EXONS; HUMANS; HYDROLYSIS; ISOENZYMES; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PHOSPHORIC MONOESTER HYDROLASES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS;

EID: 33746676294     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-006-0053-5     Document Type: Article

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