Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells

American Journal of Physiology - Renal Physiology

Volumn 291, Issue 2, 2006, Pages

  Cai, Qi ^a,d   Dmitrieva, Natalia I ^a   Ferraris, Joan D ^a   Michea, Luis F ^a,e   Salvador, Jesus M ^b,h   Hollander, M Christine ^b   Fornace, Albert J ^b,g   Fenton, Robert A ^a,f   Burg, Maurice B ^a,c  

^a Laboratory of Kidney and Electrolyte Metabolism NHBLI   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^e UNIVERSIDAD DE LOS ANDES   (Chile)

^f AARHUS UNIVERSITY   (Denmark)

^g HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^h CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Cell survival; High NaCl; High urea

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 A; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 B; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 BG; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 G; MESSENGER RNA; PROTEIN P53; SODIUM CHLORIDE; UNCLASSIFIED DRUG; UREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SEQUENCE; EPITHELIUM CELL; HISTOLOGY; KIDNEY CELL; KIDNEY MEDULLA; MORPHOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSMOLALITY; OSMOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

EID: 33746656677     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00518.2005     Document Type: Article

References (40)

1. Abdollahi A, Lord KA, Hoffman-Liebermann B, and Liebermann DA. Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines. Oncogene 6: 165-167, 1991.
2. Amanullah A, Azam N, Balliet A, Hollander C, Hoffman B, Fornace A, and Liebermann D. Cell signalling: cell survival and a Gadd45-factor deficiency (Abstract). Nature 424: 741, 2003.
3. Bankir L. Urea and the kidney. In: The Kidney (5th ed.), edited by Brenner BM and Rector FC. Philadelphia, PA: Saunders, 1996, p. 571-606.
4. Bedner E, Li X, Gorczyca W, Melamed MR, and Darzynkiewicz Z. Analysis of apoptosis by laser scanning cytometry. Cytometry 35: 181-195, 1999.
5. Cai Q, Michea L, Andrews P, Zhang Z, Rocha G, Dmitrieva N, and Burg MB. Rate of increase of osmolality determines osmotic tolerance of mouse inner medullary epithelial cells. Am J Physiol Renal Physiol 283: F792-F798, 2002.
6. Carrier F, Georgel PT, Pourquier P, Blake M, Kontny HU, Antinore MJ, Gariboldi M, Myers TG, Weinstein JN, Pommier Y, and Fornace AJ Jr. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol Cell Biol 19: 1673-1685, 1999.
7. Chakravarty D, Cai Q, Ferraris JD, Michea L, Burg MB, and Kultz D. Three GADD45 isoforms contribute to hypertonic stress phenotype of murine renal inner medullary cells. Am J Physiol Renal Physiol 283: F1020-F1029, 2002.
8. Dmitrieva N, Kultz D, Michea L, Ferraris J, and Burg M. Protection of renal inner medullary epithelial cells from apoptosis by hypertonic stress-induced p53 activation. J Biol Chem 275: 18243-18247, 2000.
9. Dmitrieva N, Michea L, and Burg M. p53 Protects renal inner medullary cells from hypertonic stress by restricting DNA replication. Am J Physiol Renal Physiol 281: F522-F530, 2001.
10. Dmitrieva NI, Bulavin DV, and Burg MB. High NaCl causes Mre11 to leave the nucleus, disrupting DNA damage signaling and repair. Am J Physiol Renal Physiol 285: F266-F274, 2003.
11. Dmitrieva NI, Cai Q, and Burg MB. Cells adapted to high NaCl have many DNA breaks and impaired DNA repair both in cell culture and in vivo. Proc Natl Acad Sci USA 101: 2317-2322, 2004.
12. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, Butel JS, and Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356: 215-221, 1992.
13. Ferraris JD, Persaud P, Williams CK, Chen Y, and Burg MB. cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/osmotic response element-binding protein. Proc Natl Acad Sci USA 99: 16800-16805, 2002.
14. Fornace AJ Jr, Nebert DW, Hollander MC, Luethy JD, Papathanasiou M, Fargnoli J, and Holbrook NJ. Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Mol Cell Biol 9: 4196-4203, 1989.
15. Friis MB, Friborg CR, Schneider L, Nielsen MB, Lambert IH, Christensen ST, and Hoffmann EK. Cell shrinkage as a signal to apoptosis in NIH 3T3 fibroblasts. J Physiol 567: 427-443, 2005.
16. Hollander MC, Kovalsky O, Salvador JM, Kim KE, Patterson AD, Haines DC, and Fornace AJ Jr. Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency. Cancer Res 61: 2487-2491, 2001.
17. Hollander MC, Sheikh MS, Bulavin DV, Lundgren K, Augeri-Henmueller L, Shehee R, Molinaro TA, Kim KE, Tolosa E, Ashwell JD, Rosenberg MP, Zhan Q, Fernandez-Salguero PM, Morgan WF, Deng CX, and Fornace AJ Jr. Genomic instability in Gadd45a-deficient mice. Nat Genet 23: 176-184, 1999.
18. Jin S, Tong T, Fan W, Fan F, Antinore MJ, Zhu X, Mazzacurati L, Li X, Petrik KL, Rajasekaran B, Wu M, and Zhan Q. GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin B1 and is independent of p38 kinase activity. Oncogene 21: 8696-8704, 2002.
19. Kultz D and Chakravarty D. Hyperosmolality in the form of elevated NaCl but not urea causes DNA damage in murine kidney cells. Proc Natl Acad Sci USA 98: 1999-2004, 2001.
20. Kultz D, Madhany S, and Burg MB. Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2. J Biol Chem 273: 13645-13651, 1998.
21. Liebermann DA and Hoffman B. Myeloid differentiation (MyD) primary response genes in hematopoiesis. Oncogene 21: 3391-3402, 2002.
22. Mak SK and Kultz D. Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress. J Biol Chem 279: 39075-39084, 2004.
23. Masilamani S, Knepper MA, and Burg MB. Urine concentration and dilution. In: The Kidney, edited by Brenner BM. Philadelphia, PA: Saunders, 2000, p. 595-636.
24. Meek DW. The p53 response to DNA damage. DNA Repair (Amst) 3: 1049-1056, 2004.
25. Michea L, Ferguson DR, Peters EM, Andrews PM, Kirby MR, and Burg MB. Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells. Am J Physiol Renal Physiol 278: F209-F218, 2000.
26. Mita H, Tsutsui J, Takekawa M, Witten EA, and Saito H. Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding. Mol Cell Biol 22: 4544-4555, 2002.
27. Mosner J, Mummenbrauer T, Bauer C, Sczakiel G, Grosse F, and Deppert W. Negative feedback regulation of wild-type p53 biosynthesis. EMBO J 14: 4442-4449, 1995.
28. Rauchman MI, Nigam SK, Delpire E, and Gullans SR. An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse. Am J Physiol Renal Fluid Electrolyte Physiol 265: F416-F424, 1993.
29. Salvador JM, Hollander MC, Nguyen AT, Kopp JB, Barisoni L, Moore JK, Ashwell JD, and Fornace AJ Jr. Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity 16: 499-508, 2002.
30. Salvador JM, Mittelstadt PR, Belova GI, Fornace AJ Jr, and Ashwell JD. The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway. Nat Immunol 6: 396-402, 2005.
31. Salvador JM, Mittelstadt PR, Guszczynski T, Copeland TD, Yamaguchi H, Appella E, Fornace AJ Jr, and Ashwell JD. Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat Immunol 6: 390-395, 2005.
32. Santos BC, Chevaile A, Hebert MJ, Zagajeski J, and Gullans SR. A combination of NaCl and urea enhances survival of IMCD cells to hyperosmolality. Am J Physiol Renal Physiol 274: F1167-F1173, 1998.
33. Takekawa M and Saito H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAP-KKK. Cell 95: 521-530, 1998.
34. Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, DiStefano PS, Chiang LW and Greenberg ME. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296: 530-534, 2002.
35. Vairapandi M, Balliet AG, Hoffman B, and Liebermann DA. GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. J Cell Physiol 192: 327-338, 2002.
36. Wang X, Gorospe M, and Holbrook NJ. gadd45 is not required for activation of c-Jun N-terminal kinase or p38 during acute stress. J Biol Chem 274: 29599-29602, 1999.
37. Wang XW, Zhan Q, Coursen JD, Khan MA, Kontny HU, Yu L, Hollander MC, O'Connor PM, Fornace AJ Jr, and Harris CC. GADD45 induction of a G2/M cell cycle checkpoint. Proc Natl Acad Sci USA 96: 3706-3711, 1999.
38. Zazzeroni F, Papa S, Algeciras-Schimnich A, Alvarez K, Melis T, Bubici C, Majewski N, Hay N, De SE, Peter ME, and Franzoso G. Gadd45β mediates the protective effects of CD40 costimulation against Fas-induced apoptosis. Blood 102: 3270-3279, 2003.
39. Zhang W, Bae I, Krishnaraju K, Azam N, Fan W, Smith K, Hoffman B, and Liebermann DA. CR6: a third member in the MyD118 and Gadd45 gene family which functions in negative growth control. Oncogene 18: 4899-4907, 1999.
40. Zhang Z, Cai Q, Michea L, Dmitrieva NI, Andrews P, and Burg MB. Proliferation and osmotic tolerance of renal inner medullary epithelial cells in vivo and in cell culture. Am J Physiol Renal Physiol 283: F302-F308, 2002.