The p53-targeting human phosphatase hCdc14A interacts with the CdkI/cyclin B complex and is differentially expressed in human cancers

Molecular Cancer

Volumn 5, Issue , 2006, Pages

  Paulsen, Michelle T ^a   Starks, Adrienne M ^a   Derheimer, Frederick A ^a   Hanasoge, Sheela ^a   Li, Liwu ^b   Dixon, Jack E ^c   Ljungman, Mats ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLIN B; CYCLIN DEPENDENT KINASE 1; MONOCLONAL ANTIBODY; PROTEIN CDC14A; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; SERINE; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ARTICLE; BLADDER CANCER; BREAST CANCER; CANCER CELL CULTURE; CARCINOGENESIS; CENTRAL NERVOUS SYSTEM TUMOR; CENTROSOME; COLON CANCER; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTERPHASE; KIDNEY CANCER; LEUKEMIA; LUNG CANCER; MELANOMA; MITOSIS; MITOSIS INHIBITION; MOLECULAR EVOLUTION; NEUROBLASTOMA; OVARY CANCER; PROSTATE CANCER; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; WILD TYPE;

AZACITIDINE; CDC2 PROTEIN KINASE; CELL LINE; CELL LINE, TUMOR; CYCLIN B; CYTIDINE TRIPHOSPHATE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; MITOSIS; MODELS, BIOLOGICAL; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEASOME INHIBITORS; PROTEIN BINDING;

EID: 33746640849     PISSN: 14764598     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-5-25     Document Type: Article

References (56)

1. Visintin R, Craig K, Hwang ES, Prinz S, Tyers M, Amon A: The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol Cell 1998, 2:709-718.
2. Gruneberg U, Glotzer M, Gartner A, Nigg EA: The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo. J Cell Biol 2002, 158:901-914.
3. Stegmeier F, Amon A: CLOSING MITOSIS: The Functions of the Cdc14 Phosphatase and Its Regulation. Annu Rev Genet 2004, 38:203-232.
4. Shou W, Seol JH, Shevchenko A, Baskerville C, Moazed D, Chen ZW, Jang J, Charbonneau H, Deshaies RJ: Exit from mitosis is triggered by Teml-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 1999, 97:233-244.
5. Visintin R, Hwang ES, Amon A: Cfil prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus [see comments]. Nature 1999, 398:818-823.
6. Azzam R, Chen SL, Shou W, Mah AS, Alexandru G, Nasmyth K, Annan RS, Carr SA, Deshaies RJ: Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science 2004, 305:516-519.
7. Shirayama M, Toth A, Galova M, Nasmyth K: APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pdsl and cyclin Clb5. Nature 1999, 402:203-207.
8. Tinker-Kulberg RL, Morgan DO: Pdsl and Espl control both anaphase and mitotic exit in normal cells and after DNA damage. Genes Dev 1999, 13:1936-1949.
9. Oliferenko S, Balasubramanian MK: Cell cycle: The Flp side of Cdc14. Current Biology 2001, 11:R872-R874.
10. Cueille N, Salimova E, Esteban V, Blanco M, Moreno S, Bueno A, Simanis V: Flpl, a fission yeast orthologue of the s. cerevisiae CDC14 gene, is not required for cyclin degradation or rumlp stabilisation at the end of mitosis. J Cell Sci 2001, 114:2649-2664.
11. Trautmann S, Wolfe BA, Jorgensen P, Tyers M, Gould KL, McCollum D: Fission yeast Clplp phosphatase regulates G2/M transition and coordination of cytokenesis with cell cycle progression. Curr Biol 2001, 11:931-940.
12. Bardin AJ, Amon A: Men and sin: what is the difference? Nature Rev Mol Cell Biol 2001, 2:815-826.
13. Mishra M, Karagiannis J, Trautmann S, Wang H, McCollum D, Balasubramanian MK: The Clplp/Flplp phosphatase ensures completion of cytokinesis in response to minor perturbation of the cell division machinery in Schizosaccharomyces pombe. J Cell Sci 2004, 117:3897-3910.
14. Wolfe BA, Gould KL: Fission yeast Clp lp phosphatase affects G2/M transition and mitotic exit through Cdc25p inactivation. Embo J 2004, 23:919-929.
15. Trautmann S, McCollum D: Distinct nuclear and cytoplasmic functions of the S. pombe Cdc14-like phosphatase Clplp/Flplp and a role for nuclear shuttling in its regulation. Curr Biol 2005, 15:1384-1389.
16. Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE: A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. J Biol Chem 1997, 272:29403-29406.
17. Vazquez-Novelle MD, Esteban V, Bueno A, Sacristan MP: Functional homology among human and fission yeast Cdc14 phosphatases. J Biol Chem 2005, 280:29144-29150.
18. Listovsky T, Zor A, Laronne A, Brandeis M: Cdk1 is essential for mammalian cyclosome/APC regulation. Exp Cell Res 2000, 255:184-191.
19. Bembenek J, Yu H: Regulation of the Anaphase-promoting Complex by the Dual Specificity Phosphatase Human Cdc14a. J Biol Chem 2001, 276:48237-48242.
20. Li L, Ljungman M, Dixon JE: The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. J Biol Chem 2000, 275:2410-2414.
21. Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK: Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. Molecular Biology ofthe Cell 2002, 13:2289-2300.
22. Mailand N, Lukas C, Kaiser BK, Jackson PK, Bartek J, Lukas J: Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Nat Cell Biol 2002, 4:317-322.
23. Wang Y, Prives C: Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases. Nature 1995, 376:88-91.
24. Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus RB, Czerniak BA, Sen S: Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet 2004, 36:55-62.
25. Ljungman M: Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress. Neoplasia 2000, 2:208-225.
26. Wong AK, Chen Y, Lian L, Ha PC, Petersen K, Laity K, Carillo A, Emerson M, Heichman K, Gupte J, Tavtigian SV, Teng DH: Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene. Genomics 1999, 59:248-251.
27. Cameron EE, Bachman KE, Myöhänen S, Herman JG, Baylin SP: Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nature Gen 1999, 21:103-107.
28. Yang X, Ferguson AT, Nass SJ, Phillips DL, Butash KA, Wang SM, Herman JG, Davidson NE: Transcriptional activation of estrogen receptor alpha in human breast cancer cells by histone deacetylase inhibition. Cancer Res 2000, 60:6890-6894.
29. Dubois MF, Nguyen VT, Bellier S, Bensaude O: Inhibitors of transcription such as 5,6-dichloro-l-beta-D- ribofuranosylbenzimidazole and isoquinoline sulfonamide derivatives (H-8 and H-7*) promote dephosphorylation of the carboxyl-terminal domain of RNA polymerase II largest subunit. J Biol Chem 1994, 269:13331-13336.
30. Marshall NF, Peng JM, Xie Z, Price DH: Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase. J Biol Chem 1996, 271:27176-27183.
31. Meijer L, Borgne A, Mulner O, Chong JPJ, Blow JJ, Inagaki N, Inagaki M, Delcros JG, Moulinoux JP: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem 1997, 243:527-536.
32. Sielecki TM, Boylan JF, Benfield PA, Trainor GL: Cyclin-dependent kinase inhibitors: Useful targets in cell cycle regulation. J Med Chem 2000, 43:1-18.
33. Ljungman M, Paulsen MT: The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382. Mol Pharm 2001, 60:785-789.
34. Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, Hwang D, Goldberg AL: Inhibitors of the proteosome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 1994, 78:761-771.
35. O'Connor PM, Jackman J, Bae I, Myers TG, Fan SJ, Mutoh M, Scudiero DA, Monks A, Sausville EA, Weinstein JN, Friend S, Fornace AJ,Kohn KW: Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res 1997, 57:4285-4300.
36. De Souza CP, Ellem KA, Gabrielli BG: Centrosomal and cytoplasmic Cdc2/ cyclin BI activation precedes nuclear mitotic events. Exp Cell Res 2000, 257:11-21.
37. Jackman M, Lindon C, Nigg EA, Pines J: Active cyclin Bl-Cdkl first appears on centrosomes in prophase. Nat Cell Biol 2003, 5:143-148.
38. Kaiser BK, Nachury MV, Gardner BE, Jackson PK: Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division. BMC Cell Biol 2004, 5:27.
39. Tarapore P, Tokuyama Y, Horn HF, Fukasawa K: Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53. Oncogene 2001, 20:6851-6863.
40. Tarapore P, Fukasawa K: Loss of p53 and centrosome hyperamplification [Review]. Oncogene 2002, 21:6234-6240.
41. Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF: Abnormal centrosome amplification in the absence of p53. Science 1996, 271:1744-1747.
42. Pockwinse SM, Krockmalnic G, Doxsey SJ, Nickerson J, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Penman S: Cell cycle independent interaction of CDC2 with the centrosome, which is associated with the nuclear matrix-intermediate filament scaffold. Proc Natl Acad Sci U S A 1997, 94:3022-3027.
43. Okuda M, Horn HF, Tarapore P, Tokuyama Y, Smulian AG, Chan PK, Knudsen ES, Hofmann IA, Snyder JD, Bove KE, Fukasawa K: Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell 2000, 103:127-140.
44. Meraldi P, Nigg EA: Centrosome cohesion is regulated by a balance of kinase and phosphatase activities. J Cell Sci 2001, 114:3749-3757.
45. Lane HA, Nigg EA: Antibody microinjection reveals an essential role for human polo-like kinase I (Plkl) in the functional maturation of mitotic centrosomes. J Cell Biol 1996, 135:1701-1713.
46. Bischoff JR, Plowman GD: The Aurora/lpllp kinase family: regulators of chromosome segregation and cytokinesis. Trends Cell Biol 1999, 9:454-459.
47. Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR, Sen S: Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 1998, 20:189-193.
48. Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K, Saya H: Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 2003, 114:585-598.
49. Hsu LC, White RL: BRCAI is associated with the centrosome during mitosis. Proc Natl Acad Sci U S A 1998, 95:12983-12988.
50. Baylin SB, Esteller M, Rountree MR, Bachman KE, Schuebel K, Herman JG: Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum Mol Gen 2001, 10:687-692.
51. Yang X, Phillips DL, Ferguson AT, Nelson WG, Herman JG, Davidson NE: Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells. Cancer Res 2001, 61:7025-7029.
52. Andreassen PR, Lacroix FB, Villa-Moruzzi E, Margolis RL: Differential subcellular localization of protein phosphatase-1 alpha, gammal, and delta isoforms during both interphase and mitosis in mammalian cells. J Cell Biol 1998, 141:1207-1215.
53. Katayama H, Zhou H, Li Q, Tatsuka M, Sen S: Interaction and Feedback Regulation between STKI5/BTAK/Aurora-A Kinase and Protein Phosphatase I through Mitotic Cell Division Cycle. J Biol Chem 2001, 276:46219-46224.
54. Ljungman M, O'Hagan HM, Paulsen MT: Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation. Oncogene 2001, 20:5964-5971.
55. Ljungman M, Zhang FF, Chen F, Rainbow AJ, McKay BC: Inhibition of RNA polymer-ase II as a trigger for the p53 response. Oncogene 1999, 18:583-592.
56. O'Hagan HM, Ljungman M: Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2. Oncogene 2004, 23:5505-5512.