Gerontological aspects of genome peptide regulation

Gerontological Aspects of Genome Peptide Regulation

Volumn , Issue , 2005, Pages

  Khavinson, Vladimir Kh ^a,b   Malinin, Vladimir V ^a  

^a INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^b RUSSIAN ACADEMY OF SCIENCES   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33746544742     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Book

References (212)

1. Acker J, Wintzerith M, Vigneron M, Kedinger C Structure of the gene encoding the 14.5 kDa subunit of human RNA polymerase II. Nucleic Acids Res 1993;21:5345-5350.
2. Alberts B, Bray D, Lewis J, et al Molecular Biology of the Cell, ed 3. New York/London, Garland Publishing, 1994.
3. Alimova IN, Bashurin DA, Popovich IG, et al Effect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU mice. Vopr Onkol 2002;48:57-60.
4. Andrews GR The priority of basic research on aging vulnerability in a comprehensive research agenda on aging for the 21st century. Novartis Found Symp 2001;235:4-9; discussion 9-10.
5. Anisimov SV, Boheler KR, Khavinson VKh, Anisimov VN Studies of the effects of Vilon and Epitalon on gene expression in mouse heart using DNA-microarray technology. Bull Exp Biol Med 2002;133:293-299.
6. Anisimov VN Molecular and Physiological Mechanisms of Aging. St. Petersburg, Nauka, 2003.
7. Anisimov VN The physiological functions of the epiphysis (the gerontological aspect). Ross Fiziol Zh Im I M Sechenova 1997;83:1-13.
8. Anisimov VN, Alimova IN The use of mutagenic and transgenic mice for the study of aging mechanisms and age pathology. Adv Gerontol 2001;7:72-94.
9. Anisimov VN, Khavinson VKh, Mikhalski AI, Yashin AI Effect of synthetic thymic and pineal peptides on biomarkers of aging, survival and spontaneous tumor incidence in female CBA mice. Mech Age Dev 2001;122:41-68.
10. Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA Inhibitory effect of peptide epitalon in colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Cancer Lett 2002;183:1-8.
11. Anisimov VN, Khavinson VKh, Provinciali M, et al Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in Her-2/NEU transgenic mice. Int J Cancer 2002;101:7-10.
12. Anochin KV, Ryabinin AE Expressions of c-fos and c-jun genes in the neocortex and hippocampus of mice after passive avoidance learning. Int J Memory 1993;1:67-70.
13. Arking R The Biology of Aging, ed 2. Sunderland, Sinauer, 1998.
14. Ashmarin IP, Lelekova TV, Sanzhieva LT The effectiveness of ultralow doses and concentrations of biologically active compounds. Izv Akad Nauk SSSR Biol 1992;4:531-536.
15. Atchley WR, Wollenberg KR, Fitch WM, et al Correlation among amino acid sites in bHLH protein domains: An information theoretic analysis. Mol Biol Evol 2000;17: 164-178.
16. Arushanyan EB, Arushanyan LG, El'kebyan KS The place of pineal adrenocorticotrope relationship in the correction regulation of behaviour. Uspekhi Physiol Sci 1993;24:12-23.
17. Ashmarin IP, Koroleva SV Regulatory Peptides. Bioinformative Approach to the Investigation of Functional Continuum. Advances in Functional Neurochemistry. St. Petersburg, St. Petersburg State University Press, 2003.
18. Bach I The LIM domain: Regulation by association. Mech Dev 2000;91:5-17.
19. Badiu C, Coculescu M, Moller M Arginine vasotocin mRNA revealed by in situ hybridization in bovine pineal gland cells. Cell Tissue Res 1999;295:225-229.
20. Bartsch H, Buchberger A, Franz H, et al Effect of melatonin and pineal extracts on human ovarian and mammary tumour cells in a chemosensitivity assay. Life Sci 2000;67: 2953-2960.
21. Belokrylov GA, Popova OYa, Derevnina ON, et al Immuno-, phagocytosis modulating and antitoxic properties of amino acids and peptide preparations. Drug Dev Ind Pharm 1998;24:115-127.
22. Benson B, Machen N, Dunn AM, Wise ME Chronic lateral ventricle infusion of a pineal gland-derived decapeptide alters pulsatile secretion of LH in rats. Life Sci 1996;58: 1083-1090.
23. Botchkov NP Genetics for the medicine of the 21st century. Vestnik Russ Military Medl Acad 1999;1:44-47.
24. Bodey B, Kaiser HE Development of Hassall's bodies of the thymus in humans and other vertebrates (especially mammals) under physiological and pathological conditions: immunocytochemical, electronmicroscopic and in vitro observations. In Vivo 1997;11: 61-85.
25. Boldyrev AA Carnosin. Biological Significance and Possibilities of Medical Application. Moscow, Moscow State University Press, 1998.
26. Bonavera JJ, Swerdloff RS, Sinha Hakim AP, et al Aging results in attenuated gonadotropin releasing hormone-luteinizing hormone axis responsiveness to glutamate receptor agonist N-methyl-Daspartate. J Endocrinol 1998;10:93-99.
27. Bredas J-L (ed) Conjugated Oligomers, Polymers, and Dendrimers: From Polyacetilene to DNA. Proc 4th Francqui Colloquium. Paris, De Berg University, 1998.
28. Brodsky VYa, Khavinson VKh, Zolytarev Yu A, et al Rhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of peptide Livagen. Izv AN Ser Biol 2001;5: 517-521.
29. Bullitt E Expression of c-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat. J Comp Neurol 1990;296:517-530.
30. Campbell IL, Stalder AK, Akwa Y, et al Transgenic models to study the actions of cytokines in the central nervous system. Neuroimmunomodulation 1998;5:126-135.
31. Cao SX, Dhahbi JM, Mote PL, Spindler SR Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. Proc Natl Acad Sci USA 2001;98:10630-10635.
32. Chakravarti B, Abraham GN Aging and T-cell-mediated immunity. Mech Aging Dev 1999;108: 183-206.
33. Chazov EI, Isachenkov VA Pineal gland: The Place and the Role in the System of Neuroendocrine Regulation. Moscow, Nauka, 1974.
34. Cheido MA, Idova GV, Pansuevich OS The peptide modulation of immune reactions. Eksp Klin Farmakol 1993;56:51.
35. Chen X, Herbert J Regional changes in c-fos expression in the basal forebrain and brainstem during adaptation to repeated stress: Correlations with cardiovascular, hypothermic and endocrine responses. Neuroscience 1995;64:675-685.
36. Chernova AA http://www.maths.ox.ac.uk./_chernova/codes/belok.htm
37. Chipens GI, Freidlin IS, Skliarova SN Origin and evolution of peptide-protein bioregulators. Zh Evol Biokhim Fiziol 1987;23:361-372.
38. Cho H, Kim TK, Mancebo H, et al A protein phosphatase functions to recycle RNA polymerase II. Genes Dev 1999;13:1540-1552.
39. Darcissac EC, Bahr GM, Pouillart PR, et al Selective potentiation of cytokine expression in human whole blood by murabutide, a muramyl dipeptide analogue. Cytokine 1996;8: 658-666.
40. Dawson D, van den Heuvel CJ Integrating the actions of melatonin on human physiology. Ann Med 1998;30:95-102.
41. Debeljuk L, Lasaga M Modulation of the hypothalamo-pituitary-gonadal axis and the pineal gland by neurokinin A, neuropeptide K and neuropeptide gamma. Peptides 1999;20:285-299.
42. Derenzini M, Sirri V, Pession A, et al Quantitative changes of the two major AgNOR proteins, nucleolin and protein B23, related to stimulation of rDNA transcription. Exp Cell Res 1995;219: 276-282.
43. Dilman VM Ontogenetic model of aging and disease formation and mechanisms of natural selection. J Theor Biol 1986;118:73-81.
44. Dilman VM Aging, rate of aging and cancer. A search for preventive treatment. Ann NY Acad Sci 1994; 719:454- 455.
45. Duncan MJ, Herron JM, Hill SA Aging selectively suppresses vasoactive intestinal peptide messenger RNA expression in the suprachiasmatic nucleus of the Syrian hamster. Brain Res Mol Brain Res 2001;87:196-203.
46. Dynlacht BD Regulation of transcription by protein, that control the cell cycle. Nature 1997;389: 149-152.
47. Elmore LW, Holt SE Telomerase and telomere stability: A new class of tumor suppressor? Mol Carcinog 2000;28:1- 4
48. Erlwanger RH, Unmack MA, Grondahl ML, et al Effect of age on vasoactive intestinal polypeptideinduced short-circuit current in porcine jejunum. Comp Biochem Physiol Mol Integr Physiol 1999;124:29-33.
49. Evans WE, McLeod HL Pharmacogenomics drug disposition, drug targets, and side effects. N Engl J Med 2003;348:538-549.
50. Finch C Longevity, senescence and the genome. Univ of Chicago Press, Illinois, 1990.
51. Frolkis VV On the regulatory mechanism of molecular-genetic alterations during aging. Exp Geront 1970;5:37- 47.
52. Gallagher K, Sharp K Electrostatic contributions to heat capacity changes of DNA-ligand binding. Biophys J 1998;75:769 -776.
53. Garrity PA, Chen D, Rothenberg EV, Wold BJ Interleukin-2 transcription is regulated in vivo at the level of coordinate binding of both constitutive and regulated factors. Mol Cell Biol 1994;14: 2159-2169.
54. Goldstein R Arginine-vasotocin (AVT) - a pineal hormone in mammals. Rom J Endocrinol 1992;30: 21- 44.
55. Golubev AG Catecholamines, steroids and aging of the nervous and endocrine systems. Uspekhi Sovremennoi Biol 1989;6:64-75.
56. Grishina TV, Mulberg AA, Golovko OI, et al Physical-chemical characteristics of nuclear proteins isolated from brain tissue and spleen cells regulating IL-2 gene expression. Neurochemistry 1996;13:90-97.
57. Grokhovsky SL, Surovaya AN, Zhuze AL, Gursky GV Interaction of synthetic peptide containing a part of DNA-binding domain of v-Jun transcription activator with DNA. Mol Biol 1994a;28:1128-1136.
58. Grokhovsky SL, Surovaya AN, Zhuze AL, Gursky GV Synthesis and binding to DNA of the two peptides, modeling the DNA-binding domain of transcription activator v-Jun. Mol Biol 1994b; 28:1137-1148.
59. Gutman GM Global dialogue, global solutions. IAG Newsletter 2002;17:1-2.
60. Gutterman JU Biologic therapy of human cancer. Cancer 1992;70:906-908.
61. Harman D Aging and disease: Extending functional life span. Ann NY Acad Sci 1996;786:321-336.
62. Harrison SC A structural taxonomy of DNA-binding domains. Nature 1991;353:715-719.
63. Hayflick L The future of aging. Nature 2000;408:267-269.
64. Heliot L, Mongelard F, Klein C, et al Nonrandom distribution of metaphase AgNOR staining patterns on human acrocentric chromosomes. J Histochem Cytochem 2000;48:13-20.
65. Hemminki A. The molecular basis and clinical aspects of Peutz-Jeghers syndrome. Cell Mol Life Sci 1999;55:735-750.
66. Herzel H, Ebeling W, Schnutt AO Entropies of biosequences: The role of repeats. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 1994;50:5061-5071.
67. Hipkiss AR, Brownson C, Carrier MJ Carnosine, the anti-aging, anti-oxidant dipeptide, may react with protein carbonyl groups. Mech Aging Dev 2001;122:1431-1445.
68. Hiyama E, Hiyama K, Yokoyama T, et al Correlating telomerase activity levels with human neuroblastoma outcomes. Nat Med 1995;1:249-255.
69. Honkaniemi J, Kainu T, Ceccatelli S, et al Fos and Jun rat central amygdaloid nucleus after stress. Mol Neurosci 1992;3:849-852.
70. Hunt SP, Pint A, Evan G Induction of c-fos like protein in spinal cord neurons following sensory stimulation. Nature 1987;328:632-663.
71. Hwang DM, Dempsey AA, Wang RX, et al A genome-based resource for molecular cardiovascular medicine: Toward a compendium of cardiovascular genes. Circulation 1997;96:4146-4203.
72. Ivanov SD, Kovan'ko EG, Popovich IG, Zabezhinskii MA Assessment of genotoxicity and late effects of radiation and chemical exposures. Radiats Biol Radioecol 1999;39: 418- 424.
73. Ivanov VT, Karelin AA, Philippova MM, et al Hemoglobin as a source of endogenous bioactive peptides: The concept of tissue-specific peptide pool. Biopolymers 1997;43:171-188.
74. Jawhari A, Laine JP, Dubaele S, et al p52 mediates XPB function within the transcription / repair factor TF II H. J Biol Chem 2002;277:31761-31767.
75. Kabanov AV, Kabanov VA DNA Complexes with polycations for the delivery of genetic material into cells. Bioconjugate Chem 1995;6:7-20.
76. Kaskow JW, Regmi A, Mulchahey JJ, et al Changes in brain corticotropin-releasing factor messenger RNA expression in aged Fischer 344 rats. Brain Res 1999;822:228-230.
77. Kayo T, Allison DB, Weindruch R, Prolla TA Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci USA 2001;98: 5093-5098.
78. Kazakova TB, Burov SV, Golovko OI, et al: Biological activity of analogs of peptide hormone luliberin in the regulation of immune response of T lymphocytes. Bull Eksp Biol Med 1996;122:334 -337.
79. Khavinson VK Peptides and aging. Neuro-Endocrinol Lett 2002;23(suppl 3):special issue.
80. Khavinson VK Tetrapeptide revealing geroprotective effect, pharmacological substance on its basis, and the method of its application. US 6,727,227, 2004.
81. Khavinson VKh, Barinov VA, Arutjunyan AV, Malinin VV Free Radical Oxidation and Aging. St. Petersburg, Nauka, 2003a.
82. Khavinson VKh, Bondarev IE, Butyugov AA Epitalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med 2003b;135:590-592.
83. Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD The peptide promotes the overcoming of the limit of somatic human cells division. Bull Exp Biol Med 2004a;137: 573-577.
84. Khavinson VKh, Lezhava TA, Malinin VV Effects of short peptides on lymphocyte chromatin in senile subjects. Bull Exp Biol Med 2004b;137:78-81.
85. Khavinson VKh, Lezhava TA, Monaselidze JG, et al Effects of Livagen peptide on chromatin activation in lymphocytes from old people. Bull Exp Biol Med 2002a;134:389-392.
86. Khavinson VKh, Malinin VV Mechanisms underlying geroprotective effects of peptides. Bull Exp Biol Med 2002;133:1-5.
87. Khavinson VKh, Malinin VV, Trofimova SV, Zemchikhina VN Inductive activity of retinal peptides. Bull Exp Biol Med 2002b;134:482- 484.
88. Khavinson VKh, Zhukov VV Thymus peptides and mechanisms of immunomodulation. Uspekhi Sovremennoi Biol 1992;112:554 -570.
89. Khavinson VKh, Morozov VG Peptides of Pineal Gland and Thymus in Aging Regulation. St. Petersburg, Foliant, 2001.
90. Khavinson V, Morozov V Peptides of pineal gland and thymus prolong human life. Neuro-Endocrinol Lett 2003;24:233-240.
91. Khavinson VKh, Morozov VG, Malinin VV, Grigoriev EI Tetrapeptide stimulating functional activity of neurons, pharmacological agent based thereon and method of use thereof. EP 1 224 212 B1, 2003c.
92. Khavinson VKh, Morozov VG, Malinin VV, Sery SV Use of a dipeptide for stimulating repair processes. US 6,642,201 B1, 2003d.
93. Khavinson VKh, Shataeva LK, Bondarev IE A model of interaction between regulatory peptides and DNA double helix. Uspekhi Sovremennoi Biol 2003e;123:467-474.
94. Khelimsky AM: Epiphysis (Pineal Gland). Moscow, Meditsina, 1969.
95. Khirokava K Thymus and aging; in Makinodan T, Yunis E (eds): Immunology and Aging. Moscow, Mir, 1980.
96. Kida S, Pantazis A, Weller RO CSF drains directly from the subarachnoid space into nasal lympatics in the rat: Anatomy, histology and immunological significance. Neuropathol Appl Neurobiol 1993; 19:480-488.
97. Kirkwood TB Genes that shape the course of aging. Trends Endocrinol Metab 2003;14: 345-347.
98. Klimov PK, Barashkova GM Endogenous peptides as a single system of regulatory substances. Fiziol Zh Im I M Sechenova 1993;79:80-87.
99. Korkushko OV, Khavinson VKh, Butenko GM, Shatilo VB Peptide Preparations of Thymus and Pineal Gland in Prevention of Accelerated Aging. St. Petersburg, Nauka, 2002.
100. Korneva EA, Potin VV Effect of destruction of the posterior hypothalamic nuclei on the thyrotropic and exophthalmic activity of the rabbit hypophysis. Fiziol Zh SSSR Im I M Sechenova 1970;56: 159-164.
101. Korneva EA, Shhinek EK Hormones and Immune System. Leningrad, Nauka, 1988.
102. Korochkin LI, Mikhailov AT Introduction in Neurogenetics. Moscow, Nauka, 2000.
103. Kovacs KJ C-fos as a transcription factor: A stressful (re)view from a functional map. Neurochem Int 1998;33:287-297.
104. Kovaks KJ, Sawchenko PE Glucocorticoid negative feedback is exerted selectively on vasopressin gene transcription in parvocellular neurosecretory neurons. Soc Neurosci Abstr 1997;27:797-798.
105. Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Mol Cell Neurosci 1998;11:161-172.
106. Kuzis K, Coffin JD, Eckenstein FP Time course and age dependence of motor neuron death following facial nerve crush injury: Role of fibroblast growth factor. Exp Neurol 1999;157:77-87.
107. Kuznik BI, Morozov VG, Khavinson VK Cytomedins: 25 Years of Experimental and Clinical Study. St. Petersburg, Nauka, 1998.
108. Kuznik BI, Pinelis IS, Khavinson VK Application of Peptide Bioregulators in Stomatology. St. Petersburg, Aesculapius, 1999.
109. Lear JD, Schneider JP, Kenker PK Electrostatic effects on ion selectivity and rectification in designed ion channel peptides. J Am Chem Soc 1997;119:3212-3217.
110. Leo A, Hansch C, Elkins D Partition coefficients and their uses. Chem Rev 1971;6:525- 616.
111. Levine JE, Prystowsky MB Polypeptide growth factors in the nucleus: A review of function and translocation. Neuroimmunomodulation 1995;2:290-298.
112. Lezhava TA Chromosomes in Very Senile Age: 80 Years and Over. Moscow, Nauka, 1999.
113. Lezhava TA Chromosome and aging: Genetic conception of aging. Biogerontology 2001;2:253-260.
114. Lindfors K, Halttunen T, Huotari P, et al Identification of novel transcription factor-like gene from human intestinal cells. Biochem Biophys Res Commun 2000;276:660-666.
115. Lodish H, Berk A, Zipursky SL, et al Molecular Cell Biology, ed 4. London, Freeman, 2000.
116. Lundgren M, Chow C, Sabbattini P, et al Transcription factor dosage affects changes in higher order chromatin structure associated with activation of a heterochromatic gene. Cell 2000;103:733-743.
117. Mah N, Stoehr H, Schulz HL et al Identification of a novel retina-specific gene located in a subtelomeric region with polymorphic distribution among multiple human chromosomes. BBA 2001; 1522:167-174.
118. Mandal SS, Cho H, Kim S, et al FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunits of RNA polymerase II, stimulates transcription elongation. Mol Cell Biol 2002;22: 7543-7552.
119. Marin F, Boya J, Calvo JL, et al Immunocytochemical localization of basic fibroblast growth factor in the rat pineal gland. J Pineal Res 1994;16:44-49.
120. Marsili V, Mancinelli L, Calzuola I, Gianfranceschi GL Small acidic peptides and peptidomimetic molecules: cell growth and differentiation. Riv Biol 2000;93:175-181.
121. Mazzone SB, Geraghty DP Altered respiratory response to substance P and reduced NK1 receptor binding in the nucleus of the solitary tract of aged rats. Brain Res 1999;826: 139-142.
122. McDowell T, Gibbons R, Sutherland H, et al Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes. Proc Natl Acad Sci USA 1999;96:13983-13988.
123. McNulty JA, Tsai SY, Fox LM, et al Neurotrophic effects of the pineal gland P. Role of non-neuronal cells in co-cultures of the pineal gland and superior cervical ganglia. J Pineal Res 1995;19:40-50.
124. Medina S, Del Rio M, Fernandez MD, et al Changes with age in the modulation of natural killer activity of murine leukocytes by gastrin-releasing peptide, neuropeptide Y and sulfated cholecystokinin octapeptide. Neuropeptides 1998;32:549-555.
125. Melia KR, Ryabinin AE, Schroeder R, et al Induction and habituation of immediate early gene expression in rat brain by acute and repeated restraint stress. J Neurosci 1994;14: 5929-5938.
126. Meßmer UK, Reed JC, Brüne B Bcl-2 protects macrophages from nitric oxide-induced apoptosis. J Biol Chem 1996;47:20192-20197.
127. Meyerson M, Counter C, Eaton EN, et al hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 1997;90: 785-795.
128. Mhanna MJ, Dreshaj IA, Haxhui MA, Martin RJ Mechanism for substance P-induced relaxation of precontracted airway smooth muscle during development. Am J Physiol 1999;276:L51-L56.
129. Middendorff R, Maronde E, Paust HJ, et al Expression of C-type natriuretic peptide in the bovine pineal gland. J Neurochem 1996;67:517-524.
130. Miller MM, Bennett HJ, Billiar RB, et al Estrogen, the ovary, and neurotransmitters: factors associated with aging. Exp Gerontol 1998;33:729-757.
131. Mita K, Tsuji H, Morimyo M, et al The human gene encoding the largest subunit of RNA polymerase II. Gene 1995;159:285-286.
132. Mitchell PJ, Tijan R Transcriptional regulation in mammalian cells by sequence-specific DNA-binding proteins. Science 1989;245:371-378.
133. Moller M, Ravault JP, Cozzi B The chemical neuroanatomy of the mammalian pineal gland: neuropeptides. Neurochem Int 1996;28:23-33.
134. Morozov VG, Khavinson VK Cytomedins - a new class of the biological regulators of multicellular systems. Uspekhi Sovremennoi Biol 1983;96:339-352.
135. Morozov VG, Khavinson VK Peptide bioregulators (25 years of experimental and clinical study). St. Petersburg, Nauka, 1996.
136. Morozov VG, Khavinson VK Natural and synthetic thymic peptides as therapeutics for immune dysfunction. Int J Immunopharmacol 1997;19:501-505.
137. Morozov VG, Khavinson VK, Malinin VV Peptide Thymomimetics. St. Petersburg, Nauka, 2000.
138. Moujir F, Sanchez-Franco F, Santana C, et al Immunoreactive levels of pineal arginine vasopressin change during the rat estrous cycle. J Pineal Res 1990;8:359-366.
139. Mouzaki A, Weil R, Muster L, Rungger D. Silencing and transactivation of the mouse interleikin-2 gene in Xenopus oocytes by proteins from resting and mitogen-induced primary T-lymphocytes. EMBO J 1991;10:1399-1406.
140. Mulchahey JJ, Kaskow JW, Plotsky PM, Hauger RL Steroidal regulation of portal arginine-vasopressin levels in aged Fischer 344 rats. Brain Res 1999;822:243-245.
141. Mulligan T, Iranmanesh A, Kerzner R, et al Two-week pulsatile gonadotropin releasing hormone infusion unmasks dual (hypothalamic and Leydig cell) defects in the healthy aging male gonadotropic axis. Eur J Endocrinol 1999;141:257-266.
142. Nandel FS, Malik N, Virdi M, Singh B Designing of peptides with left handed helical structure by incorporating the unusual amino acids. Indian J Biochem Biophys 1999;36:195-203.
143. Odagiri Y, Uchida H, Hosokawa M, et al Accelerated accumulation of somatic mutations in the senescence-accelerated mouse. Nat Genet 1998;19:116 -117.
144. Ogryzko VV, Kotani T, Zhang X, et al Histone-like TAFs within the PSAF histone acetilase complex. Cell 1998;94:35- 44.
145. Oladehin A, Blatteis CM Lipopolysaccharide-induced Fos expression in hypothalamic nuclei of neunatal rats. Neuroimmunorehabilitation 1995;2:282-289.
146. Olson M, Dundr M, Szebeni A The nucleolus: An old factory with unexpected capabilities. Trends Cell Biol 2000;10:189-196.
147. Ouyang Q, Cicek G, Westendorp RG, et al Reduced IFN-gamma production in elderly people following in vitro stimulation with influenza vaccine and endotoxin. Mech Age Dev 2000;121:131-137.
148. Pabo CO, Sauer RT Transcription factors: Structural families and principles of DNA recognition. Ann Rev Biochem 1992;61:1053-1095.
149. Paltsev MA, Ivanov AA Intercellular Interactions. Moscow, Meditsina, 1995.
150. Park MK, Kogo H, Kawashima S, Wakabayashi K Characterization of gonadotropin-releasing hormone (GnRH)-immunoreactive protein in the rat pineal gland. J Neurosci Res 1995;41:386-393.
151. Parkinson G, Wilson C, Gunasekera A, et al Structure of the CAP-DNA complex at 2.5Å resolution: A complete picture of the protein-DNA interface. J Mol Biol 1996;60:395-408.
152. Pawelec G, Effros RB, Caruso C, et al T cells and aging. Front Biosci 1999;4:D216-D269.
153. Pauling L A molecular theory of general anesthesia. Science 1961;134:15-21.
154. Pekary AE, Hershman JM Tumor necrosis factor, ceramide, transforming growth factor-beta1, and aging reduce Na_/I- symporter messenger ribonucleic acid levels in FRTL-5 cells. Endocrinology 1998;139:703-712.
155. Petrov RV, Mikhailova AA, Fomina LA, Stepanenko RN Myelopeptides. Moscow, Nauka, 1997.
156. Petrov RV, Khaitov RM Immune response and aging. Uspekhi Sovremennoi Biol 1975;79:111-127.
157. Pietrowsky R, Struben C, Molle M, Fehm HL Brain potential changes after intranasal vs. intravenous administration of vasopressin: Evidence for a direct nose-brain effect in humans. Biol Psychiatry 1996a;39:332-340.
158. Pietrowsky R, Thiemann A, Kern W, et al A nose-brain pathway for psychotropic peptides: Evidence from a brain evoked potential study with cholecystokinine. Psychoneuroendocrinology 1996b;21: 559-572.
159. Popov EM Protein structural organization; in Protein problems, vol 3. Moscow, Nauka, 1997.
160. Raikhlin NT, Bukaeva IA, Smirnova EA, et al Argyrophilic proteins from the nuclear organizer domain expression in thymocytes and epithelial cells of human thymus under conditions of combined cultivation under peptides vilon and epitalon action. Bull Exp Biol Med 2004;137:667- 670.
161. Reiter RJ The pineal gland and melatonin in relation to aging: A summary of the theories and of the data. Exp Gerontol 1995;30:199-212.
162. Rentzeperis D, Marky LA, Dwyer TJ, et al Interaction of minor groove ligands to an AAATT/AATTT site correlation of thermodynamic characterization and solution structure. Biochemistry 1995;34: 2937-2945.
163. Rogers WO, Weaver CT, Kraus L, et al Visualization of antigen-specific T cell activation and cytokine expression in vivo. J Immunol 1997;158:649-657.
164. Roudenok V, Kuhnel W, Rogov Y, Nerovnja A Developmental changes in vasoactive intestinal polypeptide immunoreactivity in the human paravertebral ganglia. Anat Anz 1999;181:561-565.
165. Rosenfeld SV, Togo EF, Mikheev VS, et al Effect of epitalon on the incidence of chromosome aberrations in senescence-accelerated mice. Bull Exp Biol Med 2002;133:274-276.
166. Rufer N, Dragowska W, Thornbury G, et al Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat Biotechnol 1998;16:743-747.
167. Ryadnova IYu, Shataeva LK, Khavinson VK DNA-protein interaction studied in model systems. Polym Sci Ser [A] 2000;42:551-556.
168. Ryu DD, Nam DH Recent progress in biomolecular engineering. Biotechnol Prog 2000;16:2-16.
169. Ryu S, Zhou S, Ladurner AG, Tijan R The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Nature 1999;397:446-450.
170. Sahu A, Kalra SP Absence of increased neuropeptide Y neuronal activity before and during the luteinizing hormone (LH) surge may underlie the attenuated preovulatory LH surge in middle-aged rats. Endocrinology 1998;139:696-702.
171. Sazanov LA, Zaitsev SV Effect of superlow doses (10-18-10-14 M) of biologically active substances: General rules, features, and possible mechanisms. Biokhimiia 1992;57:1443-1460.
172. Schmallhausen II Cybernetic Problems of Biology. Novosibirsk, Nauka SO, 1968.
173. Schondorf T, Kurbacher CM, Becker M, et al Heterogeneity of proteinkinase C activity and PKC-zeta expression in clinical breast carcinomas. Clin Exp Med 2001;1:1-8.
174. Seeman NC, Rosenberg JM, Rich A Sequence-specific recognition of double helical nucleic acids by proteins. Proc Natl Acad Sci USA 1976;73:804-808.
175. Sei J, Vitkovic L, Yokoyama MM Cytokines in the central nervous system: Regulatory roles in neuronal function, cell death and repair. Neuroimmunomodulation 1995;2:121-133.
176. Senba E, Umemoto S, Kawai Y, Noguchi K Differential expression of fos family and jun family mRNAs in the rat hypothalamo-pituitary-adrenal axis after immobilization stress. Brain Res Mol Brain Res 1994;24:283-294.
177. Shataeva LK, Khavinson VK, Ryadnova IY Peptide Self-Regulation of Living Systems (Facts and Hypotheses). St. Petersburg, Nauka, 2003.
178. Shataeva LK, Ryadnova IY, Khavinson VK Information value of olygopeptide blocks in regulatory peptides and proteins. Uspekhi Sovremennoi Biol 2002;122:282-289.
179. Sibarov DA, Kovalenko RI, Malinin VV, Khavinson VK Epitalon influences pineal secretion in stressexposed rats in the daytime. Neuro Endocrinol Lett 2002a;23:452-454.
180. Sibarov DA, Kovalenko RI, Nozdrachev AD, et al Ef fects of pineal gland peptides on the electric acti vity of pinealocytes in rats. Dokl Biol Sci 2002b;385:331-333.
181. Sirri V, Roussel P, Trere D, et al Amount variability of total and individual Ag-NOR proteins in cells stimulated to proliferate. J Histochem Cytochem 1995;43:887-893.
182. Stepan H, Leitner E, Bader M, Walther T Organ-specific mRNA distribution of C-type natriuretic peptide in neonatal and adult mice. Regul Pept 2000;95:81-85.
183. Sudakov KV Individual Resistance to Emotional Stress. Moscow, 1998.
184. Suske G The Sp-family of transcription factors. Gene 1999;238:291-300.
185. Swanson LW Brain Maps: Computer Graphics Files. Amsterdam, Elsevier Science, 1992.
186. Takeda T Senescence-accelerated mouse (SAM): A biogerontological resource in aging research. Neurobiol Aging 1999;20:105-110.
187. Tavernarakis N, Driscoll M Caloric restriction and life span: A role for protein turnover? Mech Age Dev 2002;123:215-229
188. Terwel D, Markerink M, Jolles J Age-related changes in concentrations of vasopressin in the central nervous system and plasma of the male Wistar rat. Mech Age Dev 1992;65:127-136.
189. Tollet-Egnell P, Flores-Morales A, Stahlberg N, et al Gene expression profile of the aging process in rat liver: normalizing effects of growth hormone replacement. Mol Endocrinol 2001;15: 308-318.
190. Tucker JD, Spruill MD, Ramsey MJ, et al Frequency of spontaneous chromosome aberrations in mice: effects of age. Mutat Res 1999;425:135-141.
191. Unlap T, Jope PS Dexamethazone attenuates kainate-induced AP-1 activation in rat brain. Molecular Brain Res 1994;24:275-282.
192. Van der Zee EA, Jansen K, Gerkema MP Severe loss of vasopressin-immunoreactive cells in the suprachiasmatic nucleus of aging voles coincides with reduced circadian organization of running wheel activity. Brain Res 1999;816:572-579.
193. Van Holde KE Chromatin. New York, Springer, 1988.
194. Verrecchio A, Germann MW, Schick BP, et al Design of peptides with high affinities for heparin and endothelial cell proteoglycans. J Biol Chem 2000;275:7701-7707.
195. Vijg J Somatic mutations and aging: A re-evaluation. Mutat Res 2000;447:117-135.
196. Wainer PK, Langridge R, Blaney JM, Kollman PA Electrostatic potential molecular surfaces. Proc Nat Acad Sci USA 1982;79:3754-3758.
197. Wang X, Zhang R, Gong P, Gong S A study on the specific binding of some drugs with DNA and DNA bases. Abstr 3rd Ann Life Spring Forum of Biosci, IT and Capitals, Dalian, China, 2004.
198. Weindruch R, Kayo T, Lee C-K, Prolla TA Gene expression profiling of aging using DNA microarrays. Mech Age Dev 2002;123:177-193.
199. Weiss O, Jimenez-Montano MA, Herzel H Information content of protein sequences. J Theoret Biol 2000;206:379-386.
200. Wenner M, Kawamura N, Ishikawa T Reward linked to increased natural killer cell activity in rats. Neuroimmunomodulation 2000;7:1-5.
201. Wick V, Zubov D, Hagen G Genomic organisation and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT). Gene 1999;232: 97-106.
202. Wilson HL, McFie PJ, Roesler WJ Different transcription factor binding arrays modulate the cAMP responsivity of the phosphoenolpyruvate carboxykinase gene promoter. J Biol Chem 2002;277: 43895- 43902.
203. Wolfe SA, Zhou P, Dotsch V, et al Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc. Nature 1997;385:172-176.
204. Worth LL, Jia SF, An T, Kleinerman ES ImmTher, a lipophilic disaccharide derivative of muramyl dipeptide, up-regulates specific monocyte cytokine genes and activates monocyte-mediated tumoricidal activity. Cancer Immunol Immunother 1999;48:312-320.
205. Wright WE, Shay JW Historical claims and current interpretations of replicative aging. Nat Biotechnol 2002;20:682-688.
206. Yaseen NR, Maizel AL, Wang F, Sharma S Comparative analysis of NFAT complex in human T and B lymphocytes. J Biol Chem 1993;268:14285-14293.
207. Yokoyama C, Sasaki K Regional expression of c-fos-like immunoreactivity in rat cerebral cortex after stress: Restraint and intraperitoneal lipopolysaccharide. Brain Res 1999;816: 267-275.
208. Yu BP, Yang R Critical evaluation of the free radical theory of aging: a proposal for the oxidative stress hypothesis. Ann NY Acad Sci 1996;786:1-11.
209. Zamyatnin AA Dilatometry in Protein Solutions. Moscow, Nauka, 1973.
210. Zenger V Principles of nucleic acids structural organization. Moscow, Mir, 1987.
211. Zhao H, Patra A, Yeh CC, et al Effects of aging on growth factors gene and protein expression in the dorsal and ventral lobes of rat prostate. Biochem Biophys Res Commun 2002;292:482-491.
212. Zhou T, Chiang CM The intronless and NFNF-less human TAF (II) 55 gene contains a functional initiator and downstream promoter element. J Biol Chem 2001;276: 25503-25511.