Changes in brain corticotropin-releasing factor messenger RNA expression in aged Fischer 344 rats

Brain Research

Volumn 822, Issue 1-2, 1999, Pages 228-230

  Kasckow, John W ^a,b,c   Regmi, Ajit ^b   Mulchahey, James J ^b   Plotsky, Paul M ^d   Hauger, Richard L ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Brain; Corticotropin releasing factor; Messenger RNA; Rat; Stress

Indexed keywords

CORTICOTROPIN RELEASING FACTOR;

AGING; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTICLE; COGNITION; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRESS; STRIA TERMINALIS;

AGING; AMYGDALA; ANIMALS; BRAIN CHEMISTRY; CORTICOTROPIN-RELEASING HORMONE; GENE EXPRESSION; MALE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, INBRED F344; RNA, MESSENGER; STRESS;

EID: 0033586294     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)01365-1     Document Type: Article

References (18)

1. W. Bondareff, C. Mountjoy, M. Roth, Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia, Neurology 32 (1982) 164-168.
2. S. Ceccatelli, L. Calza, L. Giardino, Age-related changes in the expression of corticotropin-releasing hormone receptor mRNA in the rat pituitary, Mol. Brain Res. 37 (1996) 175-180.
3. G. Cizza, A.E. Calogero, L.S. Brady, G. Bagdy, E. Bergamini, M.R. Blackman, G.P. Chrousos, P.W. Gold, Male Fischer-344/N rats show a progressive central impairment of the hypothalamic-pituitary-adrenal axis with advancing age, Endocrinology 134 (1994) 1611-1620.
4. M.M. Davis , D.L. Walker, Y. Lee, Roles of the amygdala and bed nucleus of the stria terminalis in fear and anxiety measured with the acoustic startle reflex, Ann. NY Acad. Sci. 821 (1997) 305-331.
5. L. Givalois, S. Li, G. Pelletier, Age-related decrease in the hypothalamic CRH mRNA expression is reduced by dehydroepiandrosterone (DHEA) treatment in male and female rats, Mol. Brain Res. 48 (1997) 107-114.
6. R.L. Hauger, M.R. Irwin, M. Lorang, G. Aguilera, M.R. Brown, High intracerebral levels of CRH result in CRH receptor downregulation in the amygdala and neuroimmune desensitization, Brain Res. 616 (1993) 283-292.
7. R.L. Hauger, M.A. Millan, M. Lorang, J.P. Harwood, G. Aguilera, Corticotropin-releasing factor receptors and pituitary adrenal responses during immobilization stress, Endocrinology 123 (1988) 396-405.
8. R.L. Hauger, K.V. Thrivikraman, P.M. Plotsky, Age-related alterations of hypothalamic-pituitary-adrenal axis function in male Fischer 344 rats, Endocrinology 134 (1994) 1528-1536.
9. J.P. Herman, W.E. Cullinan, Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis, Trends in Neurosci. 20 (1997) 78-84.
10. J.A. Heroux, D.E. Grigoriadis, E.B. DeSouza, Age-related decreases in corticotropin-releasing factor (CRF) receptors in rat brain and anterior pituitary gland, Brain Res. 54 (1991) 155-158.
11. M. Lorang, M. Irwin, S. Knapp, R.L. Hauger, CRF regulation of the hypothalamic-pituitary-adrenal (HPA) axis in aging, in: 71st Annual Meeting of the Endocrine Society Abstracts, Seattle, WA, 1989, p. 142.
12. S.J. Lupien, M. de Leon, S. de Santi, A. Convit, C. Tarshish, N.P.V. Nair, M. Thakur, B.S. McEwen, R.L. Hauger, M.J. Meaney, Cortisol levels during human aging predict hippocampal atrophy and memory deficits, Nature Neurosci. 1 (1998) 69-73.
13. E.R. Peskind, D. Wingerson, S. Murray, M. Pascualy, D.J. Dobie, P.L. Corre, R. LeVerge, R.C. Weith, M.A. Raskind, Effects of Alzheimer's disease and normal aging on cerebrospinal fluid norepinephrine responses to yohimbine and clonidine, Arch. Gen. Psychiatry 52 (1995) 774-782.
14. P.M. Plotsky, K.V. Thrivikraman, R.L. Hauger, Age-related dysregulation of CRF and AVP circuits in F344 male rats, in: 25th Annual Meeting of the International Society for Psychoneuroendocrinology Abstracts, Seattle, WA, 1994, p. 24.
15. Y. Tizabi, G. Aguilera, G.M. Gilad, Age related reduction in pituitary corticotropin-releasing hormone receptors in two rat strains, Neurobiol. Aging 13 (1992) 227-230.
16. W.W. Vale, J. Vaughan, M. Perrin, Corticotropin-releasing factor (CRF) family of ligands and their receptors, The Endocrinologist 7 (1997) 3S-9S.
17. G.B. Varty, R.L. Hauger, M.A. Geyer, Aging effects on the startle response and startle plasticity, Neurobiol. of Aging 19 (1998) 243-251.
18. C.W. Wilkinson, E.R. Peskind, M.A. Raskind, Decreased hypothalamic-pituitary-adrenal axis sensitivity to cortisol feedback inhibition in human aging, Neuroendocrinology 65 (1997) 79-90.