Peptides of pineal gland and thymus prolong human life

Neuroendocrinology Letters

Volumn 24, Issue 3-4, 2003, Pages 233-240

  Khavinson, Vladimir Kh ^a   Morozov, Vyacheslav G ^a  

^a INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

Aging; Epiphysis; Epithalamin; Geroprotectors; Life span; Peptides; Thymalin; Thymus

Indexed keywords

EPITHALAMIN; PLACEBO; REGULATOR PROTEIN; TIMALIN;

ACUTE RESPIRATORY TRACT DISEASE; AGE; AGED; ARTICLE; CARDIOVASCULAR FUNCTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; ENDOCRINE FUNCTION; FEMALE; FUNCTIONAL ASSESSMENT; HEALTH STATUS; HOMEOSTASIS; HUMAN; HUMAN TISSUE; HYPERTENSION; IMMUNE SYSTEM; INCIDENCE; ISCHEMIC HEART DISEASE; LIFESPAN; LONGEVITY; MAJOR CLINICAL STUDY; MALE; MEDICAL RESEARCH; MORTALITY; NERVOUS SYSTEM; OSTEOARTHRITIS; OSTEOPOROSIS; PATHOLOGY; PINEAL BODY; PREVENTION; RANDOMIZED CONTROLLED TRIAL; SOCIAL CARE; STATISTICAL SIGNIFICANCE; THYMUS; TREATMENT OUTCOME;

EID: 0042285895     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Arking R. Biology of aging: observations and principles. 2nd ed. SunderLand (MA): Sinauer Associates; 1998.
2. Austad SN. Why we age: what science is discovering about the body's journey through life. New York:John WiLey & Sons; 1997.
3. Harman D. Aging: Overview. Ann NY Acad Sci 2001; 928: 1-21.
4. Pierpaoli W. Neuroimmunomodulation of aging: A program in the pineal gland. Ann NY Acad Sci 1998; 840:491-497.
5. Savino W, Vila-Verde DMS, Alves LA, Dardenne M. Neuroendocrine control of the thymus. Ann NY Acad Sci 1998; 840: 470-479.
6. Rattan SIS. Biogerontology: the next step. Ann NY Acad Sci 2000; 908:282-290.
7. Kirkwood TBL. Molecular gerontology: Bridging the simple and the complex. Ann NY Acad Sci 2000; 908:14-20.
8. Khavinson VKh. Peptides and ageing. Neuroendocrinology Lett (Special Issue) 2002; 23 (Suppl 3):144.
9. Morozov VG, Khavinson VKh. Natural and synthetic thymic peptides as therapeutics for immune dysfunction. Int J Immunopharmacology 1997; 19(9/10):501-505.
10. Khavinson VKh, Morozov VG. An application of thymus and epiphysis preparation for the age-related pathology prophylaxis. Proceedings of the 16th World Congress of the International Association of Gerontology; Aug 19-23, 1997; Adelaide, Australia; 1997. p. 212(644).
11. Khavinson VKh, Morozov VG. Novel approaches to the prevention and treatment of age-associated pathology using peptide bioregulators - Epithalamin and Thymalin. Proceedings of the Pan-American Congress on Gerontology and Geriatrics "Aging of Americans"; Feb 21-24, 1999; San Antonio, USA; 1999. p. 46.
12. Anisimov VN, Mylnikov SV, Khavinson VKh. Pineal peptide preparation Epithalamin slows down aging in D. melanogatser, mice and rats. Age 1997; 20(3):186.
13. Anisimov VN, Mylnikov SV, Oparina TI, Khavinson VKh. Effect of melatonin and pineal peptide preparation Epithalamin on life span and free radical oxidation in Drosophila melanogaster. Mech Ageing Dev 1997; 97:81-91.
14. Anisimov VN, Mylnikov SV, Khavinson VKh. Pineal peptide preparation Epithalamin increases the lifespan of fruit flies, mice and rats. Mech Ageing Dev 1998; 103:123-132.
15. Anisimov VN, Mylnikov SV, Khavinson VKh. The pineal peptide preparation, Epithalamin, slows down agin in Drosophila melanogaster, mice and rats. Ann NY Acad Sci 1998; 854:481.
16. Anisimov A Khavinson VKh, Morozov VG. Carcinogenesis and aging. IV. Effect of low-molecular-weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and life span of C3H/Sn mice. Mech Ageing Dev 1982; 19:245-258.
17. Anisimov VN, Loktionov AS, Khavinson VKh, Morozov VG. Effect of Low-molecular-weight factors of thymus and pineal gland on life span and spontaneous tumour development in female mice of different age. Mech Ageing Dev 1989; 49:245-257.
18. Khavinson VKh, Morozov VG, Anisimov VN. Twenty years of study on thymic peptides application in gerontology. Proceedings of the III European Congress of Gerontology; Aug 30-Sept 02, 1995; Amsterdam, Holland; 1995.
19. Khavinson VKh, Morozov VG, Solovyova DV. New approach to the treatment of geriatric patients. Proceedings of the III Congress of the International Association of Gerontology European Region - Clinical Section; Nov 14-17, 1996; Thessaloniki, Greece; 1996. p. 177.
20. Khavinson VKh, Morozov VG. Bioregulating therapy as a new direction in medicine. Proceedings of the II National Congress of Gerontology and Geriatrics; May 28-31, 1997; Bucharest, Romania; 1997. p. 205.
21. Khavinson VKh, Morozov VG, Malinin VV. Mechanism of action of pineal gland and thymus peptide bioregulators in the ageing process. Proceedings of the 1st European Congress of Biogerontology; Aug 28-Sept 02, 1998; Helsingor, Denmark; 1998. p. 61.
22. Khavinson VKh, Solovyova DV. New approach to the prophylaxis and treatment of age-related pathology. Romanian J Geront Geriat 1998; 20(1):28-34.
23. Dilman VM, Anisimov VN, Ostroumova MN, Morozov VG, Khavinson VKh, Azarova MA. Study of the anti-tumor effect of poly-peptide pineal extract. Oncology 1979; 36(6):274-280.
24. Dilman VM, Anisimov VN, Ostroumova MN, Khavinson VKh, Morozov VG. Increase in life span of rats following polypeptide pineal extract treatment. Exp Pathol 1979; 17(9):539-545.
25. Anisimov VN, Bondarenko LA, Khavinson VKh. Effect of pineal peptide preparation (Epithalamin) on life span and pineal and serum melatonin level in old rats. Ann NY Acad Sci 1992; 673: 53-57.
26. Anisimov VN, Khavinson VKh, Morozov VG. Twenty years of study on effect of pineal peptide preparation: Epithalamin in experimental gerontology and oncology. Ann NY Acad Sci 1994; 719:483-493.
27. Anisimov VN, Khavinson VKh, Morozov VG. Results of 25-years study of pineal peptide preparation Epithalamin in experimental gerontology. Proceedings of the 16th Congress of the International Association of Gerontology; Aug 19-23, 1997; Adelaide, Australia; 1997. p. 512(1565).
28. Goncharova ND, Lapin BA, Khavinson VKh. Age-related endocrine disturbances and possible ways of their corrections. Proceedings of the 3rd European Congress of Biogerontology; Nov 8-11, 2002; Florence, Italy. Biogerontology; 2002; 3(1). p.53.
29. Anisimov VN, Arutjunyan AV, Khavinson VKh. Effects of pineal preparation Epithalamin on free-radical processes in humans and animals. Neuroendocrinology Lett 2001; 22(1):9-18.
30. Khavinson VKh, Morozov VG, Anisimov VN. Experimental studies of the pineal gland preparation Epithalamin. In: Bartsch C, Bartsch H, Blask DE, Cardinali DP, Hrushevsky WJM, Mecke D, editors. The pineal gland and cancer. Berlin, Heidelberg: Springer-Verlag; 2001. 578.
31. Khavinson VKh. Peptide regulation of aging. Proceedings of the 17th World Congress of the International Association of Gerontology; Jul 1-6, 2001; Vancouver, Canada. Gerontology; 2001; 47(1). p. 545.
32. Campbell MJ, Machin D. Medical Statistics: A commonsense approach. 3rd ed. Chinchester: John Wiley & Sons; 1999. p. 203.
33. Korkushko OV, Chebotarev DF, Shatilo VB, Polyukhov AM. The results of 30-months use of Thymalin and Epithalamin in people with manifestations of an accelerated aging. International Symposium "Gerontological Aspects of Peptide Regulation of Organism Functions"; St. Petersburg: Nauka; 1996.
34. Korkushko OV, Khavinson VKh, Shatilo VB. Peptide preparations from thymus and pineal gland may be used for slowing-down of accelerated human aging. Proceedings of the 3rd European Congress of Biogerontology; Nov 8-11, 2002; Florence, Italy. Biogerontology; 2002; 3(1). p. 65.
35. Matthews DE, Farewell VT. Using and understanding medical statistics. 3rd rev ed. Base: Karger; 1996:246.