Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH

Matrix Biology

Volumn 20, Issue 8, 2001, Pages 543-553

  Handley, Christopher J ^a,b   Tuck Mok, Meng ^b   Ilic, Mirna Z ^a   Adcocks, Clair ^c   Buttle, David J ^c   Robinson, H Clem ^b  

^a LA TROBE UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Aggrecan; Cartilage; Cathepsin D

Indexed keywords

AGGRECAN; ASPARTIC PROTEINASE INHIBITOR; CATHEPSIN D; CHONDROITIN SULFATE; CORE PROTEIN; GLYCOSAMINOGLYCAN; ISOLEUCINE; LEUCINE; PEPSTATIN; PHENYLALANINE; VALINE;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CATTLE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; EXPLANT; EXTRACELLULAR MATRIX; ISOTOPE LABELING; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; TIME;

AGGRECANS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARTILAGE, ARTICULAR; CATHEPSIN D; CATTLE; CHONDROITIN SULFATES; CULTURE TECHNIQUES; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; HYDROGEN-ION CONCENTRATION; LECTINS, C-TYPE; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; PROTEOGLYCANS;

BOVINAE;

EID: 0035197754     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0945-053X(01)00168-8     Document Type: Article

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