Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation

Matrix Biology

Volumn 21, Issue 3, 2002, Pages 271-288

  Little, Christopher B ^a,d   Hughes, Clare E ^a   Curtis, Clare L ^a   Janusz, Mike J ^b   Bohne, Richard ^b   Wang Weigand, Sherry ^b   Taiwo, Yetunde O ^b   Mitchell, Peter G ^c   Otterness, Ivan G ^c   Flannery, Carl R ^a,c   Caterson, Bruce ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^c PFIZER INC   (United States)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Aggrecanase; Cartilage catabolism; Matrix metalloproteinases

Indexed keywords

AGGREGAN; AGGREGANASE; CHONDROITIN SULFATE; ENZYME; EPITOPE; MATRIX METALLOPROTEINASE; MONOMER; PROTEIN; PROTEOGLYCAN; UNCLASSIFIED DRUG;

AGING; ARTICLE; CARBOXY TERMINAL SEQUENCE; CARTILAGE DEGENERATION; COLLAGEN METABOLISM; CONTROLLED STUDY; DISEASE COURSE; DOG; ENZYME ACTIVITY; ENZYME ANALYSIS; HORSE; HUMAN; IN VITRO STUDY; METABOLITE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN SECRETION; SYNOVIAL FLUID;

AGGRECANS; ANIMALS; BINDING SITES; CARTILAGE, ARTICULAR; CATTLE; COLLAGEN; COLLAGENASES; EXTRACELLULAR MATRIX PROTEINS; LECTINS, C-TYPE; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 3; PROTEOGLYCANS; TIME FACTORS;

EQUIDAE;

EID: 0036247674     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0945-053X(02)00004-5     Document Type: Article

References (70)

1. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family
2. Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity
3. Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase
4. The isolation and characterisation of the link proteins from proteoglycan aggregates of bovine nasal cartilage
5. Use of an antibody against the matrix metalloproteinase-generated aggrecan neoepitope FVDIPEN-COOH to assess the effects of stromelysin in a rabbit model of cartilage degradation
6. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage
7. Nitric oxide inhibits aggrecan degradation in explant cultures of equine articular cartilage
8. Passive loss of proteoglycan from articular cartilage explants
9. Inhibition of bovine nasal cartilage degradation by selective matrix metalloproteinase inhibitors
10. Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation
11. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and MMP sites
12. Monoclonal antibodies directed against epitopes within the core protein structure of the large aggregating proteoglycan (aggrecan) from the swarm rat chondrosarcoma
13. Identification of a monoclonal antibody that specifically recognizes corneal and skeletal keratan sulphate. Monoclonal antibodies to cartilage proteoglycan
14. Monoclonal antibodies as probes for determining the microheterogeneity of the link proteins of cartilage proteoglycan
15. Production and characterization of monoclonal antibodies directed against connective tissue proteoglycans
16. Anabolic and catabolic markers of proteoglycan metabolism in osteoarthritis
17. The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint
18. Mapping by monoclonal antibody detection of glycosaminoglycans in connective tissues
19. The prevention of collagen breakdown in bovine nasal cartilage by TIMP-1, TIMP-2 and a low molecular weight synthetic inhibitor
20. Improved quantitation and discrimination of sulphated glycosaminoglycan by use of dimethylmethylene blue
21. Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at the site in vivo in human articular cartilage
22. Molecular cloning and sequence analysis of the aggrecan interglobular domain from porcine, equine, bovine and ovine cartilage: Comparison of proteinase-susceptible regions and sites of keratan sulfate substitution
23. Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes
24. Expression of ADAMTS homologues in articular cartilage
25. Aggrecan catabolism in cartilage: Studies on the nature of a novel proteinase (aggrecanase) which cleaves the Glu 373-Ala 374 bond of the interglobular domain
26. Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain
27. Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: Detection of fragments in human synovial fluids
28. Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain
29. Degradation of cartilage aggrecan by collagenase-3 (MMP-13)
30. Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent
31. Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan
32. Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants
33. Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins
34. The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B
35. Regulation of proteoglycan metabolism in articular cartilage
36. Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay
37. Metalloproteinase digestion of cartilage proteoglycan. Pattern of cleavage by stromelysin and susceptibility to collagenase
38. Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: Application to catabolism in situ and in vitro
39. Monoclonal antibodies recognizing protease-generated neoepitopes from cartilage proteoglycan degradation. Application to studies of human link protein cleavage by stromelysin
40. Differential expression of aggrecanase and matrix metalloproteinase activity in chondrocytes isolated from bovine and porcine articular cartilage
41. Mechanism of catabolism of aggrecan by articular cartilage
42. Characterization of aggrecan retained and lost from the extracellular matrix of articular cartilage. Involvement of carboxy-terminal processing in the catabolism of aggrecan
43. Degradation of type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explant cultures
44. Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase in normal, osteoarthritic and rheumatoid joints
45. Aggrecanase versus matrix metalloproteinases in the interglobular domain catabolism of articular cartilage aggrecan in vitro
46. The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis
47. N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1 treated articular cartilage explant cultures
48. Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase
49. The origin of human cartilage proteglycan link-protein heterogeneity and fragmentation during aging
50. Cathepsin B: An alternative protease for the generation of an aggrecan'metalloproteinase' cleavage neoepitope
51. Link protein as a monitor in situ of endogenous proteolysis in adult human cartilage
52. Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage
53. Retinoic acid-induced type II collagen degradation does not correlate with matrix metalloproteinase activity in cartilage explant cultures
54. Articular cartilage cultured with interleukin-1. Increased release of link protein, hyaluronate-binding region and other proteoglycan fragments
55. The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain
56. The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1
57. Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo
58. VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis
59. Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis
60. Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)
61. Aggrecan degradation in human intervertebral disc and articular cartilage
62. Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism
63. Purification and cloning of aggrecanase-1: A member of the ADAMTS family of proteins
64. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation
65. Sites of cleavage by recombinant human aggrecanase-1 (ADAMTS-4)
66. Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis. A pivotal role for stromelysin in matrix metalloproteinase activity
67. Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis
68. Increased vulnerability of postarthritic cartilage to a second arthritis insult: Accelerated MMP activity in a flare up of arthritis
69. Characterization of helical cleavages in type II collagen generated by matrixins
70. Proteoglycans isolated from dissociative extracts of differently aged human articular cartilage: Characterisation of naturally occurring hyaluronan-binding fragments of aggrecan