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Volumn 31, Issue 5, 2006, Pages 461-465

Targeting SIRT1 - A multitasker

Author keywords

[No Author keywords available]

Indexed keywords

2 (CYCLOPENTYLCARBOXAMIDO) 6 METHYL 4,5,6,7 TETRAHYDRO 1 BENZOTHIOPHENE 3 CARBOXAMIDE; 2 93 CYCLOHEXYL 4 OXO 4,5,6,7 TETRAHYDRO 3H CYCLOPENTAL[4.5]THIENOL[2.3 D]PYRIMIDIN 2 YLSULFANYL)ACETIC ACID; 2 [4 BENZYL 5 (1H INDOL 3 YLMETHYL) 4H 1,2,4 TRIAZOL 3 YLSULFANYL]ACETAMIDE; 4 OXOPENTANOIC ACID 3 ACETOXY 5 [2[E] (3 ACETOXYPHENYL)VINYL]PHENYL ESTER; 6 METHYL 2 PROPIONAMIDO 4,5,6,7 TETRAHYDRO 1 BENZOTHIOPHENE 3 CARBOXAMIDE; ACETIC ACID 4 [2[E] (3,5 BIS(METHOXYMETHOXY)PHENYL)VINYL]PHENYL ESTER; BUTEIN; ENZYME INHIBITOR; EX 527; FISETIN; HISTONE DEACETYLASE 3; HR 73; ISOLIQUIRITIGENIN; NICOTINAMIDE; PICEATANNOL; POLYPHENOL DERIVATIVE; PROTEIN; PROTEIN SIRT1; QUERCETIN; RESVERATROL; SIRT1 INHIBITOR; SIRTINOL; SIRTUIN; SMALL INTERFERING RNA; SPLITOMICIN; TRANS 3,4' DIACETOXY 5 (4 OXOPENTANOYLOXY)STILBENE; TRANS 4' ACETOXY 3,5 BIS(METHOXYMETHOXY)STILBENE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; WO 2005069998; WO 2005072412;

EID: 33746338896     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2006.031.05.982834     Document Type: Review
Times cited : (3)

References (25)
  • 1
    • 3042681042 scopus 로고    scopus 로고
    • Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
    • Picard, F., Kurtev, M., Chung, N. et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ. Nature 2004, 429(6993): 771-6.
    • (2004) Nature , vol.429 , Issue.6993 , pp. 771-776
    • Picard, F.1    Kurtev, M.2    Chung, N.3
  • 2
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • Lin, J., Handschin, C., Spiegelman, B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 2005, 1(6): 361-70.
    • (2005) Cell Metab , vol.1 , Issue.6 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 3
    • 33244486764 scopus 로고    scopus 로고
    • Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
    • Bordone, L., Motta, M.C., Picard, F. et al. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells. PLoS Biol 2006, 4(2): e31.
    • (2006) PLoS Biol , vol.4 , Issue.2
    • Bordone, L.1    Motta, M.C.2    Picard, F.3
  • 4
    • 4043165678 scopus 로고    scopus 로고
    • Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
    • Araki, T., Sasaki, Y., Milbrandt, J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 2004, 305(5686): 1010-3.
    • (2004) Science , vol.305 , Issue.5686 , pp. 1010-1013
    • Araki, T.1    Sasaki, Y.2    Milbrandt, J.3
  • 5
    • 33747587373 scopus 로고    scopus 로고
    • Resveratrol mimics ischemic preconditioning in the brain
    • Advanced online publication, December 14
    • Raval, A.P., Dave, K.R., Perez-Pinzon, M.A. Resveratrol mimics ischemic preconditioning in the brain. J Cereb Blood Flow Metab 2005, Advanced online publication, December 14.
    • (2005) J Cereb Blood Flow Metab
    • Raval, A.P.1    Dave, K.R.2    Perez-Pinzon, M.A.3
  • 6
    • 28844474597 scopus 로고    scopus 로고
    • SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling
    • Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L.F., Kwon, H., Yi, S., Mucke, L., Gan, L. SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling. J Biol Chem 2005, 280(48): 40364-74.
    • (2005) J Biol Chem , vol.280 , Issue.48 , pp. 40364-40374
    • Chen, J.1    Zhou, Y.2    Mueller-Steiner, S.3    Chen, L.F.4    Kwon, H.5    Yi, S.6    Mucke, L.7    Gan, L.8
  • 7
    • 33746382123 scopus 로고    scopus 로고
    • (Elixir Pharmaceuticals, Inc.). SIRT1 and genetic disorders. WO 2005004814
    • Geesaman, B.J., Brass, L. (Elixir Pharmaceuticals, Inc.). SIRT1 and genetic disorders. WO 2005004814.
    • Geesaman, B.J.1    Brass, L.2
  • 8
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz, K.T., Bitterman, K.J., Cohen, H.Y. et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003, 425(6954): 191-6.
    • (2003) Nature , vol.425 , Issue.6954 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3
  • 9
    • 33746368580 scopus 로고    scopus 로고
    • (Harvard College; General Hospital Corp.). Compositions for treating or preventing obesity and insulin resistance disorders. WO 2005065667
    • Sinclair, D.A., Alexander-Bridges, M. (Harvard College; General Hospital Corp.). Compositions for treating or preventing obesity and insulin resistance disorders. WO 2005065667.
    • Sinclair, D.A.1    Alexander-Bridges, M.2
  • 10
    • 33746358396 scopus 로고    scopus 로고
    • (Brigham Young University). Novel sirtuin activating compounds and methods for making the same. WO 2005069998
    • Andrus, M.B., Liu, J. (Brigham Young University). Novel sirtuin activating compounds and methods for making the same. WO 2005069998.
    • Andrus, M.B.1    Liu, J.2
  • 11
    • 33344456652 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: A review of their clinical status as antineoplastic agents
    • Garcia-Manero, G., Issa, J.P. Histone deacetylase inhibitors: A review of their clinical status as antineoplastic agents. Cancer Invest 2005, 23(7): 635-42.
    • (2005) Cancer Invest , vol.23 , Issue.7 , pp. 635-642
    • Garcia-Manero, G.1    Issa, J.P.2
  • 12
    • 33645950778 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Multifunctional anticancer agents
    • In press
    • Liu, T., Kuljaca, S., Tee, A., Marshall, G.M. Histone deacetylase inhibitors: Multifunctional anticancer agents. Cancer Treat Rev 2006, In press.
    • (2006) Cancer Treat Rev
    • Liu, T.1    Kuljaca, S.2    Tee, A.3    Marshall, G.M.4
  • 13
    • 8844247034 scopus 로고    scopus 로고
    • Silent information regulator 2α, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes
    • Alcendor, R.R., Kirshenbaum, L.A., Imai, S., Vatner, S.F., Sadoshima, J. Silent information regulator 2α, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ Res 2004, 95(10): 971-80.
    • (2004) Circ Res , vol.95 , Issue.10 , pp. 971-980
    • Alcendor, R.R.1    Kirshenbaum, L.A.2    Imai, S.3    Vatner, S.F.4    Sadoshima, J.5
  • 14
    • 30544445468 scopus 로고    scopus 로고
    • Sirt1 inhibitor, sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
    • Ota, H., Tokunaga, E., Chang, K. et al. Sirt1 inhibitor, sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 2006, 25(2): 176-85.
    • (2006) Oncogene , vol.25 , Issue.2 , pp. 176-185
    • Ota, H.1    Tokunaga, E.2    Chang, K.3
  • 15
    • 28544444366 scopus 로고    scopus 로고
    • Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
    • Ford, J., Jiang, M., Milner, J. Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res 2005, 65(22): 10457-63.
    • (2005) Cancer Res , vol.65 , Issue.22 , pp. 10457-10463
    • Ford, J.1    Jiang, M.2    Milner, J.3
  • 16
    • 33746367937 scopus 로고    scopus 로고
    • (University of York). Induction of apoptosis by inhibition of sirtuin SIRT1 expression. WO 2005078091
    • Milner, A.J. (University of York). Induction of apoptosis by inhibition of sirtuin SIRT1 expression. WO 2005078091.
    • Milner, A.J.1
  • 17
    • 33746352246 scopus 로고    scopus 로고
    • (Isis Innovation, Ltd.). Tumor associated antigens. WO 2003082916
    • Banham, A., Pulford, K., Liggins, A., Guinn, B. (Isis Innovation, Ltd.). Tumor associated antigens. WO 2003082916.
    • Banham, A.1    Pulford, K.2    Liggins, A.3    Guinn, B.4
  • 18
    • 20144372893 scopus 로고    scopus 로고
    • SIRT1 regulates HIV transcription via Tat deacetylation
    • Pagans, S., Pedal, A., North, B.J. et al. SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol 2005, 3(2): e41.
    • (2005) PLoS Biol , vol.3 , Issue.2
    • Pagans, S.1    Pedal, A.2    North, B.J.3
  • 19
    • 33746327640 scopus 로고    scopus 로고
    • (University of California, Oakland). Compositions and methods for modulating sirtuin activity. WO 2005062952
    • Ott, M., Verdin, E.M., Jung, M. (University of California, Oakland). Compositions and methods for modulating sirtuin activity. WO 2005062952.
    • Ott, M.1    Verdin, E.M.2    Jung, M.3
  • 21
    • 24744458598 scopus 로고    scopus 로고
    • The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated "anti-apoptotic" pathways
    • Chong, Z.Z., Lin, S.H., Li, F., Maiese, K. The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated "anti-apoptotic" pathways. Curr Neurovasc Res 2005, 2(4): 271-85.
    • (2005) Curr Neurovasc Res , vol.2 , Issue.4 , pp. 271-285
    • Chong, Z.Z.1    Lin, S.H.2    Li, F.3    Maiese, K.4
  • 22
    • 0041571570 scopus 로고    scopus 로고
    • Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry
    • Sauve, A.A., Schramm, V.L. Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. Biochemistry 2003, 42(31): 9249-56.
    • (2003) Biochemistry , vol.42 , Issue.31 , pp. 9249-9256
    • Sauve, A.A.1    Schramm, V.L.2
  • 25
    • 33645221885 scopus 로고    scopus 로고
    • Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
    • Solomon, J.M., Pasupuleti, R., Xu, L., McDonagh, T., Curtis, R., DiStefano, P. S., Huber, L.J. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol 2006, 26(1): 28-38.
    • (2006) Mol Cell Biol , vol.26 , Issue.1 , pp. 28-38
    • Solomon, J.M.1    Pasupuleti, R.2    Xu, L.3    McDonagh, T.4    Curtis, R.5    DiStefano, P.S.6    Huber, L.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.