Differential inducible nitric oxide synthase expression in systemic and pulmonary vessels after endotoxin

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 278, Issue 5 47-5, 2000, Pages

  Pulido, Edward J ^a   Shames, Brian D ^a   Fullerton, David A ^a   Sheridan, Brett C ^a   Selzman, Craig H ^a   Gamboni Robertson, Fabia ^a   Bensard, Denis D ^a   McIntyre Jr , Robert C ^a  

^a CHILDREN S HOSPITAL   (United States)

Author keywords

Aminoguanidine; Aorta; N(G) monomethyl L arginine; Pulmonary artery; Salmonella tymphimurium

Indexed keywords

AMINOGUANIDINE; ENDOTOXIN; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME INHIBITION; HYPOTENSION; IMMUNOHISTOCHEMISTRY; LUNG BLOOD VESSEL; LUNG CIRCULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; SEPSIS; VASOCONSTRICTION; WESTERN BLOTTING;

EID: 0034084427     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.2000.278.5.r1232     Document Type: Article

References (13)

1. Akyurek LM, Fellstrom BC, Yan ZQ, Hansson GK, Funa K, and Larsson E. Inducible and endothelial nitric oxide synthase expression during development of transplant arteriosclerosis in rat aortic grafts. Am J Pathol 149: 1981-1990, 1996.
2. Arkovitz MS, Wispe JR, Garcia VF, and Szabo C. Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute endotoxemia. J Pediatr Surg 31: 1009-1015, 1996.
3. Carraway MS, Piantadosi CA, Jenkinson CP, and Huang YC. Differential expression of arginase and iNOS in the lung in sepsis. Exp Lung Res 24: 253-268, 1998.
4. Chang SW, Fedderscn CO, Henson PM, and Voelkel NF. Platelet-activating factor mediates hemodynamïc changes and lung injury in endotoxin-treated rats. J Clin Invest 79: 1498-1509, 1987.
5. Fleming I, Julou-Schaeffer G, Gray GA, Parratt JR, and Stoclet JC. Evidence that an L-arginine/nitric oxide dependent elevation of tissue cyclic GMP content is involved in depression of vascular reactivity by endotoxin. Br J Pharmacol 103: 1047-1052, 1991.
6. Fujii Y, Goldberg P, and Hussain SN. Contribution of macrophages to pulmonary nitric oxide production in septic shock. Am J Respir Crit Care Med 157: 1645-1651, 1998.
7. Fullerton DA, McIntyre RC, Hahn AR, Agrafojo J, Koike K, Meng X, Banerjee A, and Harken AH. Dysfunction of cGMP-mediated pulmonary vasorelaxation in endotoxin-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 268: L1029-L1035, 1995.
8. Geiger M, Stone A, Mason SN, Oldham KT, and Guice KS. Differential nitric oxide production by microvascular and macrovascular endothelial cells. Am J Physiol Lung Cell Mol Physiol 273: L275-L281, 1997.
9. Griffiths MJD, Curzen NP, Mitchell JA, and Evans TW. In vivo treatment with endotoxin increases rat pulmonary vascular contractility despite NOS induction. Am J Respir Crit Care Med 156: 654-658, 1997.
10. Griffiths MJD, Liu S, Curzen NP, Messent M, and Evans TW. In vivo treatment with endotoxin induces nitric oxide synthase in the rat main pulmonary artery. Am J Physiol Lung Cell Mol Physiol 268: L509-L518, 1995.
11. Gryglewski RJ, Wolkow PP, Uracz W, Janowska E, Bartus JB, Balbatun O, Patton S, Brovkovych V, and Malinski T. Protective role of pulmonary nitric oxide in the acute phase of endotoxemia in rats. Circ Res 82: 819-827, 1998.
12. Julou-Schaeffer G, Gray GA, Fleming I, Schott C, Parratt JR, and Stoclet JC. Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway. Am J Physiol Heart Circ Physiol 259: H1038-H1043, 1990.
13. Kleschyov AL, Muller B, Schott C, and Stoclet JC. Role of adventitial nitric oxide in vascular hyporeactivity induced by lipopolysaccharide in rat aorta. Br J Pharmacol 124: 623-626, 1998.