-
1
-
-
0034657914
-
Microtubule interactions with the cell cortex causing nuclear movements in Saccharomyces cerevisiae
-
Adames N.R., and Cooper J.A. Microtubule interactions with the cell cortex causing nuclear movements in Saccharomyces cerevisiae. J. Cell Biol. 149 (2000) 863-874
-
(2000)
J. Cell Biol.
, vol.149
, pp. 863-874
-
-
Adames, N.R.1
Cooper, J.A.2
-
2
-
-
16844385435
-
Characterization of the FKBP.rapamycin.FRB ternary complex
-
Banaszynski L.A., Liu C.W., and Wandless T.J. Characterization of the FKBP.rapamycin.FRB ternary complex. J. Am. Chem. Soc. 127 (2005) 4715-4721
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 4715-4721
-
-
Banaszynski, L.A.1
Liu, C.W.2
Wandless, T.J.3
-
3
-
-
0037434697
-
Dynein structure and power stroke
-
Burgess S.A., Walker M.L., Sakakibara H., Knight P.J., and Oiwa K. Dynein structure and power stroke. Nature 421 (2003) 715-718
-
(2003)
Nature
, vol.421
, pp. 715-718
-
-
Burgess, S.A.1
Walker, M.L.2
Sakakibara, H.3
Knight, P.J.4
Oiwa, K.5
-
4
-
-
0030874883
-
The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain
-
Case R.B., Pierce D.W., Hom-Booher N., Hart C.L., and Vale R.D. The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain. Cell 90 (1997) 959-966
-
(1997)
Cell
, vol.90
, pp. 959-966
-
-
Case, R.B.1
Pierce, D.W.2
Hom-Booher, N.3
Hart, C.L.4
Vale, R.D.5
-
5
-
-
0036238432
-
Defining a pathway of communication from the C-terminal peptide binding domain to the N-terminal ATPase domain in a AAA protein
-
Cashikar A.G., Schirmer E.C., Hattendorf D.A., Glover J.R., Ramakrishnan M.S., Ware D.M., and Lindquist S.L. Defining a pathway of communication from the C-terminal peptide binding domain to the N-terminal ATPase domain in a AAA protein. Mol. Cell 9 (2002) 751-760
-
(2002)
Mol. Cell
, vol.9
, pp. 751-760
-
-
Cashikar, A.G.1
Schirmer, E.C.2
Hattendorf, D.A.3
Glover, J.R.4
Ramakrishnan, M.S.5
Ware, D.M.6
Lindquist, S.L.7
-
6
-
-
13444292841
-
Single molecule high-resolution colocalization of Cy3 and Cy5 attached to macromolecules measures intramolecular distances through time
-
Churchman L.S., Okten Z., Rock R.S., Dawson J.F., and Spudich J.A. Single molecule high-resolution colocalization of Cy3 and Cy5 attached to macromolecules measures intramolecular distances through time. Proc. Natl. Acad. Sci. USA 102 (2005) 1419-1423
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 1419-1423
-
-
Churchman, L.S.1
Okten, Z.2
Rock, R.S.3
Dawson, J.F.4
Spudich, J.A.5
-
7
-
-
0141507032
-
Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains
-
DeLaBarre B., and Brunger A.T. Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains. Nat. Struct. Biol. 10 (2003) 856-863
-
(2003)
Nat. Struct. Biol.
, vol.10
, pp. 856-863
-
-
DeLaBarre, B.1
Brunger, A.T.2
-
8
-
-
0037336323
-
The structure and function of MCM from archaeal M. Thermoautotrophicum
-
Fletcher R.J., Bishop B.E., Leon R.P., Sclafani R.A., Ogata C.M., and Chen X.S. The structure and function of MCM from archaeal M. Thermoautotrophicum. Nat. Struct. Biol. 10 (2003) 160-167
-
(2003)
Nat. Struct. Biol.
, vol.10
, pp. 160-167
-
-
Fletcher, R.J.1
Bishop, B.E.2
Leon, R.P.3
Sclafani, R.A.4
Ogata, C.M.5
Chen, X.S.6
-
9
-
-
0031444202
-
An extended microtubule-binding structure within the dynein motor domain
-
Gee M.A., Heuser J.E., and Vallee R.B. An extended microtubule-binding structure within the dynein motor domain. Nature 390 (1997) 636-639
-
(1997)
Nature
, vol.390
, pp. 636-639
-
-
Gee, M.A.1
Heuser, J.E.2
Vallee, R.B.3
-
10
-
-
22544476257
-
Microtubule transport defects in neurological and ciliary disease
-
Gerdes J.M., and Katsanis N. Microtubule transport defects in neurological and ciliary disease. Cell. Mol. Life Sci. 62 (2005) 1556-1570
-
(2005)
Cell. Mol. Life Sci.
, vol.62
, pp. 1556-1570
-
-
Gerdes, J.M.1
Katsanis, N.2
-
11
-
-
0026425402
-
Multiple nucleotide-binding sites in the sequence of dynein beta heavy chain
-
Gibbons I.R., Gibbons B.H., Mocz G., and Asai D.J. Multiple nucleotide-binding sites in the sequence of dynein beta heavy chain. Nature 352 (1991) 640-643
-
(1991)
Nature
, vol.352
, pp. 640-643
-
-
Gibbons, I.R.1
Gibbons, B.H.2
Mocz, G.3
Asai, D.J.4
-
12
-
-
0023664034
-
Photosensitized cleavage of dynein heavy chains. Cleavage at the "V1 site" by irradiation at 365 nm in the presence of ATP and vanadate
-
Gibbons I.R., Lee-Eiford A., Mocz G., Phillipson C.A., Tang W.J., and Gibbons B.H. Photosensitized cleavage of dynein heavy chains. Cleavage at the "V1 site" by irradiation at 365 nm in the presence of ATP and vanadate. J. Biol. Chem. 262 (1987) 2780-2786
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 2780-2786
-
-
Gibbons, I.R.1
Lee-Eiford, A.2
Mocz, G.3
Phillipson, C.A.4
Tang, W.J.5
Gibbons, B.H.6
-
13
-
-
0021630304
-
Structural comparison of purified dynein proteins with in situ dynein arms
-
Goodenough U., and Heuser J. Structural comparison of purified dynein proteins with in situ dynein arms. J. Mol. Biol. 180 (1984) 1083-1118
-
(1984)
J. Mol. Biol.
, vol.180
, pp. 1083-1118
-
-
Goodenough, U.1
Heuser, J.2
-
14
-
-
0029737867
-
Dimeric ligands define a role for transcriptional activation domains in reinitiation
-
Ho S.N., Biggar S.R., Spencer D.M., Schreiber S.L., and Crabtree G.R. Dimeric ligands define a role for transcriptional activation domains in reinitiation. Nature 382 (1996) 822-826
-
(1996)
Nature
, vol.382
, pp. 822-826
-
-
Ho, S.N.1
Biggar, S.R.2
Spencer, D.M.3
Schreiber, S.L.4
Crabtree, G.R.5
-
15
-
-
25444452497
-
Long range allosteric control of cytoplasmic dynein ATPase activity by the stalk and C-terminal domains
-
Hook P., Mikami A., Shafer B., Chait B.T., Rosenfeld S.S., and Vallee R.B. Long range allosteric control of cytoplasmic dynein ATPase activity by the stalk and C-terminal domains. J. Biol. Chem. 280 (2005) 33045-33054
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 33045-33054
-
-
Hook, P.1
Mikami, A.2
Shafer, B.3
Chait, B.T.4
Rosenfeld, S.S.5
Vallee, R.B.6
-
16
-
-
0036469037
-
Distinguishing inchworm and hand-over-hand processive kinesin movement by neck rotation measurements
-
Hua W., Chung J., and Gelles J. Distinguishing inchworm and hand-over-hand processive kinesin movement by neck rotation measurements. Science 295 (2002) 844-848
-
(2002)
Science
, vol.295
, pp. 844-848
-
-
Hua, W.1
Chung, J.2
Gelles, J.3
-
17
-
-
0028806377
-
Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex
-
Karki S., and Holzbaur E.L. Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex. J. Biol. Chem. 270 (1995) 28806-28811
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 28806-28811
-
-
Karki, S.1
Holzbaur, E.L.2
-
18
-
-
33746221673
-
Assembly dynamics of microtubules at molecular resolution
-
10.1038/nature04928 in press. Published online June 25, 2006
-
Kerssemakers J.W.J., Munteanu E.L., Laan L., Noetzel T.L., Janson M.E., and Dogterom M. Assembly dynamics of microtubules at molecular resolution. Nature (2006) 10.1038/nature04928 in press. Published online June 25, 2006
-
(2006)
Nature
-
-
Kerssemakers, J.W.J.1
Munteanu, E.L.2
Laan, L.3
Noetzel, T.L.4
Janson, M.E.5
Dogterom, M.6
-
19
-
-
0033789351
-
Dynactin increases the processivity of the cytoplasmic dynein motor
-
King S.J., and Schroer T.A. Dynactin increases the processivity of the cytoplasmic dynein motor. Nat. Cell Biol. 2 (2000) 20-24
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 20-24
-
-
King, S.J.1
Schroer, T.A.2
-
20
-
-
22444450774
-
ATP hydrolysis cycle-dependent tail motions in cytoplasmic dynein
-
Kon T., Mogami T., Ohkura R., Nishiura M., and Sutoh K. ATP hydrolysis cycle-dependent tail motions in cytoplasmic dynein. Nat. Struct. Mol. Biol. 12 (2005) 513-519
-
(2005)
Nat. Struct. Mol. Biol.
, vol.12
, pp. 513-519
-
-
Kon, T.1
Mogami, T.2
Ohkura, R.3
Nishiura, M.4
Sutoh, K.5
-
21
-
-
4444330119
-
Distinct functions of nucleotide-binding/hydrolysis sites in the four AAA modules of cytoplasmic dynein
-
Kon T., Nishiura M., Ohkura R., Toyoshima Y.Y., and Sutoh K. Distinct functions of nucleotide-binding/hydrolysis sites in the four AAA modules of cytoplasmic dynein. Biochemistry 43 (2004) 11266-11274
-
(2004)
Biochemistry
, vol.43
, pp. 11266-11274
-
-
Kon, T.1
Nishiura, M.2
Ohkura, R.3
Toyoshima, Y.Y.4
Sutoh, K.5
-
22
-
-
0030877444
-
Identification of a microtubule-binding domain in a cytoplasmic dynein heavy chain
-
Koonce M.P. Identification of a microtubule-binding domain in a cytoplasmic dynein heavy chain. J. Biol. Chem. 272 (1997) 19714-19718
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 19714-19718
-
-
Koonce, M.P.1
-
23
-
-
0029954331
-
Overexpression of cytoplasmic dynein's globular head causes a collapse of the interphase microtubule network in Dictyostelium
-
Koonce M.P., and Samso M. Overexpression of cytoplasmic dynein's globular head causes a collapse of the interphase microtubule network in Dictyostelium. Mol. Biol. Cell 7 (1996) 935-948
-
(1996)
Mol. Biol. Cell
, vol.7
, pp. 935-948
-
-
Koonce, M.P.1
Samso, M.2
-
24
-
-
20344382542
-
Kinesin and dynein move a peroxisome in vivo: A tug-of-war or coordinated movement?
-
Kural C., Kim H., Syed S., Goshima G., Gelfand V.I., and Selvin P.R. Kinesin and dynein move a peroxisome in vivo: A tug-of-war or coordinated movement?. Science 308 (2005) 1469-1472
-
(2005)
Science
, vol.308
, pp. 1469-1472
-
-
Kural, C.1
Kim, H.2
Syed, S.3
Goshima, G.4
Gelfand, V.I.5
Selvin, P.R.6
-
25
-
-
22144491144
-
NudEL targets dynein to microtubule ends through LIS1
-
Li J., Lee W.L., and Cooper J.A. NudEL targets dynein to microtubule ends through LIS1. Nat. Cell Biol. 7 (2005) 686-690
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 686-690
-
-
Li, J.1
Lee, W.L.2
Cooper, J.A.3
-
26
-
-
0035958082
-
The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif
-
Lo K.W., Naisbitt S., Fan J.S., Sheng M., and Zhang M. The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif. J. Biol. Chem. 276 (2001) 14059-14066
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 14059-14066
-
-
Lo, K.W.1
Naisbitt, S.2
Fan, J.S.3
Sheng, M.4
Zhang, M.5
-
27
-
-
0031820288
-
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
-
Longtine M.S., McKenzie III A., Demarini D.J., Shah N.G., Wach A., Brachat A., Philippsen P., and Pringle J.R. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14 (1998) 953-961
-
(1998)
Yeast
, vol.14
, pp. 953-961
-
-
Longtine, M.S.1
McKenzie III, A.2
Demarini, D.J.3
Shah, N.G.4
Wach, A.5
Brachat, A.6
Philippsen, P.7
Pringle, J.R.8
-
28
-
-
26444460293
-
Three-dimensional reconstruction of axonemal outer dynein arms in situ by electron tomography
-
Lupetti P., Lanzavecchia S., Mercati D., Cantele F., Dallai R., and Mencarelli C. Three-dimensional reconstruction of axonemal outer dynein arms in situ by electron tomography. Cell Motil. Cytoskeleton 62 (2005) 69-83
-
(2005)
Cell Motil. Cytoskeleton
, vol.62
, pp. 69-83
-
-
Lupetti, P.1
Lanzavecchia, S.2
Mercati, D.3
Cantele, F.4
Dallai, R.5
Mencarelli, C.6
-
29
-
-
1342325553
-
Cytoplasmic dynein functions as a gear in response to load
-
Mallik R., Carter B.C., Lex S.A., King S.J., and Gross S.P. Cytoplasmic dynein functions as a gear in response to load. Nature 427 (2004) 649-652
-
(2004)
Nature
, vol.427
, pp. 649-652
-
-
Mallik, R.1
Carter, B.C.2
Lex, S.A.3
King, S.J.4
Gross, S.P.5
-
30
-
-
28444456051
-
Building complexity: An in vitro study of cytoplasmic dynein with in vivo implications
-
Mallik R., Petrov D., Lex S.A., King S.J., and Gross S.P. Building complexity: An in vitro study of cytoplasmic dynein with in vivo implications. Curr. Biol. 15 (2005) 2075-2085
-
(2005)
Curr. Biol.
, vol.15
, pp. 2075-2085
-
-
Mallik, R.1
Petrov, D.2
Lex, S.A.3
King, S.J.4
Gross, S.P.5
-
31
-
-
0032969563
-
AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes
-
Neuwald A.F., Aravind L., Spouge J.L., and Koonin E.V. AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res. 9 (1999) 27-43
-
(1999)
Genome Res.
, vol.9
, pp. 27-43
-
-
Neuwald, A.F.1
Aravind, L.2
Spouge, J.L.3
Koonin, E.V.4
-
32
-
-
27644477833
-
3D structure of eukaryotic flagella in a quiescent state revealed by cryo-electron tomography
-
Nicastro D., McIntosh J.R., and Baumeister W. 3D structure of eukaryotic flagella in a quiescent state revealed by cryo-electron tomography. Proc. Natl. Acad. Sci. USA 102 (2005) 15889-15894
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 15889-15894
-
-
Nicastro, D.1
McIntosh, J.R.2
Baumeister, W.3
-
33
-
-
2542441524
-
A single-headed recombinant fragment of Dictyostelium cytoplasmic dynein can drive the robust sliding of microtubules
-
Nishiura M., Kon T., Shiroguchi K., Ohkura R., Shima T., Toyoshima Y.Y., and Sutoh K. A single-headed recombinant fragment of Dictyostelium cytoplasmic dynein can drive the robust sliding of microtubules. J. Biol. Chem. 279 (2004) 22799-22802
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 22799-22802
-
-
Nishiura, M.1
Kon, T.2
Shiroguchi, K.3
Ohkura, R.4
Shima, T.5
Toyoshima, Y.Y.6
Sutoh, K.7
-
34
-
-
4644281092
-
Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae
-
Reck-Peterson S.L., and Vale R.D. Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 101 (2004) 1491-1495
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 1491-1495
-
-
Reck-Peterson, S.L.1
Vale, R.D.2
-
35
-
-
13944269581
-
A flexible domain is essential for the large step size and processivity of myosin VI
-
Rock R.S., Ramamurthy B., Dunn A.R., Beccafico S., Rami B.R., Morris C., Spink B.J., Franzini-Armstrong C., Spudich J.A., and Sweeney H.L. A flexible domain is essential for the large step size and processivity of myosin VI. Mol. Cell 17 (2005) 603-609
-
(2005)
Mol. Cell
, vol.17
, pp. 603-609
-
-
Rock, R.S.1
Ramamurthy, B.2
Dunn, A.R.3
Beccafico, S.4
Rami, B.R.5
Morris, C.6
Spink, B.J.7
Franzini-Armstrong, C.8
Spudich, J.A.9
Sweeney, H.L.10
-
36
-
-
0033527027
-
Inner-arm dynein c of Chlamydomonas flagella is a single-headed processive motor
-
Sakakibara H., Kojima H., Sakai Y., Katayama E., and Oiwa K. Inner-arm dynein c of Chlamydomonas flagella is a single-headed processive motor. Nature 400 (1999) 586-590
-
(1999)
Nature
, vol.400
, pp. 586-590
-
-
Sakakibara, H.1
Kojima, H.2
Sakai, Y.3
Katayama, E.4
Oiwa, K.5
-
37
-
-
3242809790
-
25 Angstrom resolution structure of a cytoplasmic dynein motor reveals a seven-member planar ring
-
Samso M., and Koonce M.P. 25 Angstrom resolution structure of a cytoplasmic dynein motor reveals a seven-member planar ring. J. Mol. Biol. 340 (2004) 1059-1072
-
(2004)
J. Mol. Biol.
, vol.340
, pp. 1059-1072
-
-
Samso, M.1
Koonce, M.P.2
-
38
-
-
0037694982
-
The third P-loop domain in cytoplasmic dynein heavy chain is essential for dynein motor function and ATP-sensitive microtubule binding
-
Silvanovich A., Li M.G., Serr M., Mische S., and Hays T.S. The third P-loop domain in cytoplasmic dynein heavy chain is essential for dynein motor function and ATP-sensitive microtubule binding. Mol. Biol. Cell 14 (2003) 1355-1365
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 1355-1365
-
-
Silvanovich, A.1
Li, M.G.2
Serr, M.3
Mische, S.4
Hays, T.S.5
-
39
-
-
4444368230
-
Multiple ATP-hydrolyzing sites that potentially function in cytoplasmic dynein
-
Takahashi Y., Edamatsu M., and Toyoshima Y.Y. Multiple ATP-hydrolyzing sites that potentially function in cytoplasmic dynein. Proc. Natl. Acad. Sci. USA 101 (2004) 12865-12869
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 12865-12869
-
-
Takahashi, Y.1
Edamatsu, M.2
Toyoshima, Y.Y.3
-
40
-
-
33645803599
-
Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein
-
Toba S., Watanabe T.M., Yamaguchi-Okimoto L., Toyoshima Y.Y., Higuchi H., Watanabe Y., Hayashi M., Yagi T., Kamiya R., Hachiya N.S., et al. Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein. Proc. Natl. Acad. Sci. USA 103 (2006) 5741-5745
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 5741-5745
-
-
Toba, S.1
Watanabe, T.M.2
Yamaguchi-Okimoto, L.3
Toyoshima, Y.Y.4
Higuchi, H.5
Watanabe, Y.6
Hayashi, M.7
Yagi, T.8
Kamiya, R.9
Hachiya, N.S.10
-
41
-
-
0343415156
-
The way things move: Looking under the hood of molecular motor proteins
-
Vale R.D., and Milligan R.A. The way things move: Looking under the hood of molecular motor proteins. Science 288 (2000) 88-95
-
(2000)
Science
, vol.288
, pp. 88-95
-
-
Vale, R.D.1
Milligan, R.A.2
-
42
-
-
0842333851
-
Dynein: An ancient motor protein involved in multiple modes of transport
-
Vallee R.B., Williams J.C., Varma D., and Barnhart L.E. Dynein: An ancient motor protein involved in multiple modes of transport. J. Neurobiol. 58 (2004) 189-200
-
(2004)
J. Neurobiol.
, vol.58
, pp. 189-200
-
-
Vallee, R.B.1
Williams, J.C.2
Varma, D.3
Barnhart, L.E.4
-
43
-
-
0028859428
-
Single cytoplasmic dynein molecule movements: Characterization and comparison with kinesin
-
Wang Z., Khan S., and Sheetz M.P. Single cytoplasmic dynein molecule movements: Characterization and comparison with kinesin. Biophys. J. 69 (1995) 2011-2023
-
(1995)
Biophys. J.
, vol.69
, pp. 2011-2023
-
-
Wang, Z.1
Khan, S.2
Sheetz, M.P.3
-
44
-
-
17844385071
-
Differential labeling of myosin V heads with quantum dots allows direct visualization of hand-over-hand processivity
-
Warshaw D.M., Kennedy G.G., Work S.S., Krementsova E.B., Beck S., and Trybus K.M. Differential labeling of myosin V heads with quantum dots allows direct visualization of hand-over-hand processivity. Biophys. J. 88 (2005) L30-L32
-
(2005)
Biophys. J.
, vol.88
-
-
Warshaw, D.M.1
Kennedy, G.G.2
Work, S.S.3
Krementsova, E.B.4
Beck, S.5
Trybus, K.M.6
-
45
-
-
0037832404
-
Myosin V walks hand-over-hand: Single fluorophore imaging with 1.5-nm localization
-
Yildiz A., Forkey J.N., McKinney S.A., Ha T., Goldman Y.E., and Selvin P.R. Myosin V walks hand-over-hand: Single fluorophore imaging with 1.5-nm localization. Science 300 (2003) 2061-2065
-
(2003)
Science
, vol.300
, pp. 2061-2065
-
-
Yildiz, A.1
Forkey, J.N.2
McKinney, S.A.3
Ha, T.4
Goldman, Y.E.5
Selvin, P.R.6
-
46
-
-
23744499004
-
Fluorescence imaging with one nanometer accuracy: application to molecular motors
-
Yildiz A., and Selvin P.R. Fluorescence imaging with one nanometer accuracy: application to molecular motors. Acc. Chem. Res. 38 (2005) 574-582
-
(2005)
Acc. Chem. Res.
, vol.38
, pp. 574-582
-
-
Yildiz, A.1
Selvin, P.R.2
|